MERTK

C-mer proto-oncogene tyrosine kinase, also known as MERTK, is a human gene.cite web | title = Entrez Gene: MERTK c-mer proto-oncogene tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10461| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP).cite web | title = Entrez Gene: MERTK c-mer proto-oncogene tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10461| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Iwase T, Tanaka M, Suzuki M, "et al." |title=Identification of protein-tyrosine kinase genes preferentially expressed in embryo stomach and gastric cancer. |journal=Biochem. Biophys. Res. Commun. |volume=194 |issue= 2 |pages= 698–705 |year= 1993 |pmid= 7688222 |doi= 10.1006/bbrc.1993.1878
*cite journal | author=Graham DK, Dawson TL, Mullaney DL, "et al." |title=Cloning and mRNA expression analysis of a novel human protooncogene, c-mer. |journal=Cell Growth Differ. |volume=5 |issue= 6 |pages= 647–57 |year= 1994 |pmid= 8086340 |doi=
*cite journal | author=Mark MR, Chen J, Hammonds RG, "et al." |title=Characterization of Gas6, a member of the superfamily of G domain-containing proteins, as a ligand for Rse and Axl. |journal=J. Biol. Chem. |volume=271 |issue= 16 |pages= 9785–9 |year= 1996 |pmid= 8621659 |doi=
*cite journal | author=Ling L, Templeton D, Kung HJ |title=Identification of the major autophosphorylation sites of Nyk/Mer, an NCAM-related receptor tyrosine kinase. |journal=J. Biol. Chem. |volume=271 |issue= 31 |pages= 18355–62 |year= 1996 |pmid= 8702477 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Nagata K, Ohashi K, Nakano T, "et al." |title=Identification of the product of growth arrest-specific gene 6 as a common ligand for Axl, Sky, and Mer receptor tyrosine kinases. |journal=J. Biol. Chem. |volume=271 |issue= 47 |pages= 30022–7 |year= 1997 |pmid= 8939948 |doi=
*cite journal | author=Georgescu MM, Kirsch KH, Shishido T, "et al." |title=Biological effects of c-Mer receptor tyrosine kinase in hematopoietic cells depend on the Grb2 binding site in the receptor and activation of NF-kappaB. |journal=Mol. Cell. Biol. |volume=19 |issue= 2 |pages= 1171–81 |year= 1999 |pmid= 9891051 |doi=
*cite journal | author=Weier HU, Fung J, Lersch RA |title=Assignment of protooncogene MERTK (a.k.a. c-mer) to human chromosome 2q14.1 by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1-2 |pages= 91–2 |year= 1999 |pmid= 10343112 |doi=
*cite journal | author=Gal A, Li Y, Thompson DA, "et al." |title=Mutations in MERTK, the human orthologue of the RCS rat retinal dystrophy gene, cause retinitis pigmentosa. |journal=Nat. Genet. |volume=26 |issue= 3 |pages= 270–1 |year= 2000 |pmid= 11062461 |doi= 10.1038/81555
*cite journal | author=Thompson DA, McHenry CL, Li Y, "et al." |title=Retinal dystrophy due to paternal isodisomy for chromosome 1 or chromosome 2, with homoallelism for mutations in RPE65 or MERTK, respectively. |journal=Am. J. Hum. Genet. |volume=70 |issue= 1 |pages= 224–9 |year= 2002 |pmid= 11727200 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yin JL, Hambly BD, Bao SS, "et al." |title=Expression of growth arrest-specific gene 6 and its receptors in dysfunctional human renal allografts. |journal=Transpl. Int. |volume=16 |issue= 9 |pages= 681–8 |year= 2004 |pmid= 12768229 |doi= 10.1007/s00147-003-0593-3
*cite journal | author=McHenry CL, Liu Y, Feng W, "et al." |title=MERTK arginine-844-cysteine in a patient with severe rod-cone dystrophy: loss of mutant protein function in transfected cells. |journal=Invest. Ophthalmol. Vis. Sci. |volume=45 |issue= 5 |pages= 1456–63 |year= 2004 |pmid= 15111602 |doi=
*cite journal | author=Chen C, Li Q, Darrow AL, "et al." |title=Mer receptor tyrosine kinase signaling participates in platelet function. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 6 |pages= 1118–23 |year= 2004 |pmid= 15130911 |doi= 10.1161/01.ATV.0000130662.30537.08
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Li Y, Mahajan NP, Webster-Cyriaque J, "et al." |title=The C-mer gene is induced by Epstein-Barr virus immediate-early protein BRLF1. |journal=J. Virol. |volume=78 |issue= 21 |pages= 11778–85 |year= 2004 |pmid= 15479819 |doi= 10.1128/JVI.78.21.11778-11785.2004
*cite journal | author=Gould WR, Baxi SM, Schroeder R, "et al." |title=Gas6 receptors Axl, Sky and Mer enhance platelet activation and regulate thrombotic responses. |journal=J. Thromb. Haemost. |volume=3 |issue= 4 |pages= 733–41 |year= 2005 |pmid= 15733062 |doi= 10.1111/j.1538-7836.2005.01186.x
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065
*cite journal | author=Graham DK, Salzberg DB, Kurtzberg J, "et al." |title=Ectopic expression of the proto-oncogene Mer in pediatric T-cell acute lymphoblastic leukemia. |journal=Clin. Cancer Res. |volume=12 |issue= 9 |pages= 2662–9 |year= 2006 |pmid= 16675557 |doi= 10.1158/1078-0432.CCR-05-2208
*cite journal | author=Tada A, Wada Y, Sato H, "et al." |title=Screening of the MERTK gene for mutations in Japanese patients with autosomal recessive retinitis pigmentosa. |journal=Mol. Vis. |volume=12 |issue= |pages= 441–4 |year= 2006 |pmid= 16710167 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes