EPHA8

EPH receptor A8, also known as EPHA8, is a human gene.cite web | title = Entrez Gene: EPHA8 EPH receptor A8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2046| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system.cite web | title = Entrez Gene: EPHA8 EPH receptor A8| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2046| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309
*cite journal | author=Holland SJ, Peles E, Pawson T, Schlessinger J |title=Cell-contact-dependent signalling in axon growth and guidance: Eph receptor tyrosine kinases and receptor protein tyrosine phosphatase beta. |journal=Curr. Opin. Neurobiol. |volume=8 |issue= 1 |pages= 117–27 |year= 1998 |pmid= 9568399 |doi=
*cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=
*cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi=
*cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=
*cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635
*cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=
*cite journal | author=Nakamoto T, Kain KH, Ginsberg MH |title=Neurobiology: New connections between integrins and axon guidance. |journal=Curr. Biol. |volume=14 |issue= 3 |pages= R121–3 |year= 2004 |pmid= 14986683 |doi=
*cite journal | author=Yamaguchi Y, Pasquale EB |title=Eph receptors in the adult brain. |journal=Curr. Opin. Neurobiol. |volume=14 |issue= 3 |pages= 288–96 |year= 2004 |pmid= 15194108 |doi= 10.1016/j.conb.2004.04.003
*cite journal | author=Murai KK, Pasquale EB |title=Eph receptors, ephrins, and synaptic function. |journal=The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry |volume=10 |issue= 4 |pages= 304–14 |year= 2004 |pmid= 15271258 |doi= 10.1177/1073858403262221
*cite journal | author=Chan J, Watt VM |title=eek and erk, new members of the eph subclass of receptor protein-tyrosine kinases. |journal=Oncogene |volume=6 |issue= 6 |pages= 1057–61 |year= 1991 |pmid= 1648701 |doi=
*cite journal | author=Park S, Sánchez MP |title=The Eek receptor, a member of the Eph family of tyrosine protein kinases, can be activated by three different Eph family ligands. |journal=Oncogene |volume=14 |issue= 5 |pages= 533–42 |year= 1997 |pmid= 9053851 |doi= 10.1038/sj.onc.1200857
*cite journal | author=Park S, Frisén J, Barbacid M |title=Aberrant axonal projections in mice lacking EphA8 (Eek) tyrosine protein kinase receptors. |journal=EMBO J. |volume=16 |issue= 11 |pages= 3106–14 |year= 1997 |pmid= 9214628 |doi= 10.1093/emboj/16.11.3106
*cite journal | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403–4 |year= 1997 |pmid= 9267020 |doi=
*cite journal | author=Lemke G |title=A coherent nomenclature for Eph receptors and their ligands. |journal=Mol. Cell. Neurosci. |volume=9 |issue= 5-6 |pages= 331–2 |year= 1998 |pmid= 9361271 |doi= 10.1006/mcne.1997.0630
*cite journal | author=Choi S, Park S |title=Phosphorylation at Tyr-838 in the kinase domain of EphA8 modulates Fyn binding to the Tyr-615 site by enhancing tyrosine kinase activity. |journal=Oncogene |volume=18 |issue= 39 |pages= 5413–22 |year= 1999 |pmid= 10498895 |doi= 10.1038/sj.onc.1202917

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