[cite web | title = Entrez Gene: ELAVL4 ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1996| accessdate = ] ]The HuD/ELAVL4 protein is an RNA-binding protein. [cite journal | author=Szabo A, Dalmau J, Manley G, "et al." |title=HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. |journal=Cell |volume=67 |issue= 2 |pages= 325–33 |year= 1991 |pmid= 1655278 |doi= ]
HuD is expressed only in neurons and it binds to AU-rich element-containing mRNAs. As a result of this interaction the half-life of the transcript is increased. HuD is important in neurons during brain development and plasticity. [cite journal |author=Nora Perrone-Bizzozero and Federico Bolognani |title=Role of HuD and other RNA-binding proteins in neural development and plasticity |journal=J Neurosci Res |volume=68 |pages=121–126 |year=2002 |pmid=11948657 |doi=10.1002/jnr.10175] [cite journal |author= Federico Bolognani and Nora Perrone-Bizzozero |title=RNA-protein interactions and control of mRNA stability in neurons |journal=J Neurosci Res |volume=86 |pages=481–489 |year=2008 |pmid=17853436 |doi=10.1002/jnr.21473]
References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Dalmau J, Furneaux HM, Cordon-Cardo C, Posner JB |title=The expression of the Hu (paraneoplastic encephalomyelitis/sensory neuronopathy) antigen in human normal and tumor tissues. |journal=Am. J. Pathol. |volume=141 |issue= 4 |pages= 881–6 |year= 1992 |pmid= 1415481 |doi=
*cite journal | author=Szabo A, Dalmau J, Manley G, "et al." |title=HuD, a paraneoplastic encephalomyelitis antigen, contains RNA-binding domains and is homologous to Elav and Sex-lethal. |journal=Cell |volume=67 |issue= 2 |pages= 325–33 |year= 1991 |pmid= 1655278 |doi=
*cite journal | author=Graus F, Ferrer I |title=Analysis of a neuronal antigen (Hu) expression in the developing rat brain detected by autoantibodies from patients with paraneoplastic encephalomyelitis. |journal=Neurosci. Lett. |volume=112 |issue= 1 |pages= 14–8 |year= 1990 |pmid= 2166930 |doi=
*cite journal | author=Sekido Y, Bader SA, Carbone DP, "et al." |title=Molecular analysis of the HuD gene encoding a paraneoplastic encephalomyelitis antigen in human lung cancer cell lines. |journal=Cancer Res. |volume=54 |issue= 18 |pages= 4988–92 |year= 1994 |pmid= 8069866 |doi=
*cite journal | author=Muresu R, Baldini A, Gress T, "et al." |title=Mapping of the gene coding for a paraneoplastic encephalomyelitis antigen (HuD) to human chromosome site 1p34. |journal=Cytogenet. Cell Genet. |volume=65 |issue= 3 |pages= 177–8 |year= 1993 |pmid= 8222755 |doi=
*cite journal | author=Torà M, Graus F, de Bolòs C, Real FX |title=Cell surface expression of paraneoplastic encephalomyelitis/sensory neuronopathy-associated Hu antigens in small-cell lung cancers and neuroblastomas. |journal=Neurology |volume=48 |issue= 3 |pages= 735–41 |year= 1997 |pmid= 9065557 |doi=
*cite journal | author=Lazarova DL, Spengler BA, Biedler JL, Ross RA |title=HuD, a neuronal-specific RNA-binding protein, is a putative regulator of N-myc pre-mRNA processing/stability in malignant human neuroblasts. |journal=Oncogene |volume=18 |issue= 17 |pages= 2703–10 |year= 1999 |pmid= 10348344 |doi= 10.1038/sj.onc.1202621
*cite journal | author=Park S, Myszka DG, Yu M, "et al." |title=HuD RNA recognition motifs play distinct roles in the formation of a stable complex with AU-rich RNA. |journal=Mol. Cell. Biol. |volume=20 |issue= 13 |pages= 4765–72 |year= 2000 |pmid= 10848602 |doi=
*cite journal | author=Wang X, Tanaka Hall TM |title=Structural basis for recognition of AU-rich element RNA by the HuD protein. |journal=Nat. Struct. Biol. |volume=8 |issue= 2 |pages= 141–5 |year= 2001 |pmid= 11175903 |doi= 10.1038/84131
*cite journal | author=Beckel-Mitchener AC, Miera A, Keller R, Perrone-Bizzozero NI |title=Poly(A) tail length-dependent stabilization of GAP-43 mRNA by the RNA-binding protein HuD. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27996–8002 |year= 2002 |pmid= 12034726 |doi= 10.1074/jbc.M201982200
*cite journal | author=Behrends U, Jandl T, Golbeck A, "et al." |title=Novel products of the HUD, HUC, NNP-1 and alpha-internexin genes identified by autologous antibody screening of a pediatric neuroblastoma library. |journal=Int. J. Cancer |volume=100 |issue= 6 |pages= 669–77 |year= 2002 |pmid= 12209604 |doi= 10.1002/ijc.10550
*cite journal | author=Aronov S, Aranda G, Behar L, Ginzburg I |title=Visualization of translated tau protein in the axons of neuronal P19 cells and characterization of tau RNP granules. |journal=J. Cell. Sci. |volume=115 |issue= Pt 19 |pages= 3817–27 |year= 2003 |pmid= 12235292 |doi=
*cite journal | author=Angenstein F, Evans AM, Settlage RE, "et al." |title=A receptor for activated C kinase is part of messenger ribonucleoprotein complexes associated with polyA-mRNAs in neurons. |journal=J. Neurosci. |volume=22 |issue= 20 |pages= 8827–37 |year= 2002 |pmid= 12388589 |doi=
*cite journal | author=Deschenes-Furry J, Belanger G, Perrone-Bizzozero N, Jasmin BJ |title=Post-transcriptional regulation of acetylcholinesterase mRNAs in nerve growth factor-treated PC12 cells by the RNA-binding protein HuD. |journal=J. Biol. Chem. |volume=278 |issue= 8 |pages= 5710–7 |year= 2003 |pmid= 12468554 |doi= 10.1074/jbc.M209383200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Plonquet A, Garcia-Pons F, Fernandez E, "et al." |title=Peptides derived from the onconeural HuD protein can elicit cytotoxic responses in HHD mouse and human. |journal=J. Neuroimmunol. |volume=142 |issue= 1-2 |pages= 93–100 |year= 2004 |pmid= 14512168 |doi=
*cite journal | author=Saito K, Fujiwara T, Katahira J, "et al." |title=TAP/NXF1, the primary mRNA export receptor, specifically interacts with a neuronal RNA-binding protein HuD. |journal=Biochem. Biophys. Res. Commun. |volume=321 |issue= 2 |pages= 291–7 |year= 2004 |pmid= 15358174 |doi= 10.1016/j.bbrc.2004.06.140
*cite journal | author=Rousseau A, Benyahia B, Dalmau J, "et al." |title=T cell response to Hu-D peptides in patients with anti-Hu syndrome. |journal=J. Neurooncol. |volume=71 |issue= 3 |pages= 231–6 |year= 2005 |pmid= 15735910 |doi= 10.1007/s11060-004-1723-1
*cite journal | author=Noureddine MA, Qin XJ, Oliveira SA, "et al." |title=Association between the neuron-specific RNA-binding protein ELAVL4 and Parkinson disease. |journal=Hum. Genet. |volume=117 |issue= 1 |pages= 27–33 |year= 2005 |pmid= 15827745 |doi= 10.1007/s00439-005-1259-2
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
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