ERV3

Endogenous retroviral sequence 3 (includes zinc finger protein H-plk/HPF9), also known as ERV3, is a human gene.cite web | title = Entrez Gene: ERV3 endogenous retroviral sequence 3 (includes zinc finger protein H-plk/HPF9)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2086| accessdate = ]

PBB_Summary
section_title =
summary_text = The human genome includes many retroelements including the human endogenous retroviruses (HERVs). ERV3, one of the most studied HERVs, is thought to have integrated 30 to 40 million years ago and is present in higher primates with the exception of gorillas. Taken together, the observation of genome conservation, the detection of transcript expression, and the presence of conserved ORFs is circumstantial evidence for a functional role. A functional role is also suggested by the observation that downregulation of ERV3 is reported in choriocarcinoma.cite web | title = Entrez Gene: ERV3 endogenous retroviral sequence 3 (includes zinc finger protein H-plk/HPF9)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2086| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Sasaki T |title= [Integration and expression of human endogenous retrovirus] |journal=Hokkaido Igaku Zasshi |volume=66 |issue= 6 |pages= 794–803 |year= 1992 |pmid= 1783368 |doi=
*cite journal | author=Kato N, Shimotohno K, VanLeeuwen D, Cohen M |title=Human proviral mRNAs down regulated in choriocarcinoma encode a zinc finger protein related to Krüppel. |journal=Mol. Cell. Biol. |volume=10 |issue= 8 |pages= 4401–5 |year= 1990 |pmid= 2115127 |doi=
*cite journal | author=Kato N, Pfeifer-Ohlsson S, Kato M, "et al." |title=Tissue-specific expression of human provirus ERV3 mRNA in human placenta: two of the three ERV3 mRNAs contain human cellular sequences. |journal=J. Virol. |volume=61 |issue= 7 |pages= 2182–91 |year= 1987 |pmid= 2884330 |doi=
*cite journal | author=Kato N, Larsson E, Cohen M |title=Absence of expression of a human endogenous retrovirus is correlated with choriocarcinoma. |journal=Int. J. Cancer |volume=41 |issue= 3 |pages= 380–5 |year= 1988 |pmid= 3346101 |doi=
*cite journal | author=Cohen M, Kato N, Larsson E |title=ERV3 human endogenous provirus mRNAs are expressed in normal and malignant tissues and cells, but not in choriocarcinoma tumor cells. |journal=J. Cell. Biochem. |volume=36 |issue= 2 |pages= 121–8 |year= 1988 |pmid= 3356751 |doi= 10.1002/jcb.240360203
*cite journal | author=Cohen M, Powers M, O'Connell C, Kato N |title=The nucleotide sequence of the env gene from the human provirus ERV3 and isolation and characterization of an ERV3-specific cDNA. |journal=Virology |volume=147 |issue= 2 |pages= 449–58 |year= 1986 |pmid= 3840930 |doi=
*cite journal | author=O'Connell C, O'Brien S, Nash WG, Cohen M |title=ERV3, a full-length human endogenous provirus: chromosomal localization and evolutionary relationships. |journal=Virology |volume=138 |issue= 2 |pages= 225–35 |year= 1984 |pmid= 6495650 |doi=
*cite journal | author=O'Connell CD, Cohen M |title=The long terminal repeat sequences of a novel human endogenous retrovirus. |journal=Science |volume=226 |issue= 4679 |pages= 1204–6 |year= 1985 |pmid= 6505687 |doi=
*cite journal | author=Venables PJ, Brookes SM, Griffiths D, "et al." |title=Abundance of an endogenous retroviral envelope protein in placental trophoblasts suggests a biological function. |journal=Virology |volume=211 |issue= 2 |pages= 589–92 |year= 1995 |pmid= 7645262 |doi= 10.1006/viro.1995.1442
*cite journal | author=Larsson E, Andersson AC, Nilsson BO |title=Expression of an endogenous retrovirus (ERV3 HERV-R) in human reproductive and embryonic tissues--evidence for a function for envelope gene products. |journal=Ups. J. Med. Sci. |volume=99 |issue= 2 |pages= 113–20 |year= 1995 |pmid= 7716822 |doi=
*cite journal | author=Andersson AC, Merza M, Venables P, "et al." |title=Elevated levels of the endogenous retrovirus ERV3 in human sebaceous glands. |journal=J. Invest. Dermatol. |volume=106 |issue= 1 |pages= 125–8 |year= 1996 |pmid= 8592062 |doi=
*cite journal | author=Larsson E, Venables P, Andersson AC, "et al." |title=Tissue and differentiation specific expression on the endogenous retrovirus ERV3 (HERV-R) in normal human tissues and during induced monocytic differentiation in the U-937 cell line. |journal=Leukemia |volume=11 Suppl 3 |issue= |pages= 142–4 |year= 1997 |pmid= 9209323 |doi=
*cite journal | author=Sibata M, Ikeda H, Katumata K, "et al." |title=Human endogenous retroviruses: expression in various organs in vivo and its regulation in vitro. |journal=Leukemia |volume=11 Suppl 3 |issue= |pages= 145–6 |year= 1997 |pmid= 9209324 |doi=
*cite journal | author=Andersson AC, Svensson AC, Rolny C, "et al." |title=Expression of human endogenous retrovirus ERV3 (HERV-R) mRNA in normal and neoplastic tissues. |journal=Int. J. Oncol. |volume=12 |issue= 2 |pages= 309–13 |year= 2001 |pmid= 9458354 |doi=
*cite journal | author=de Parseval N, Heidmann T |title=Physiological knockout of the envelope gene of the single-copy ERV-3 human endogenous retrovirus in a fraction of the Caucasian population. |journal=J. Virol. |volume=72 |issue= 4 |pages= 3442–5 |year= 1998 |pmid= 9525678 |doi=
*cite journal | author=Rasmussen HB, Clausen J |title=Large number of polymorphic nucleotides and a termination codon in the env gene of the endogenous human retrovirus ERV3. |journal=Dis. Markers |volume=14 |issue= 3 |pages= 127–33 |year= 1999 |pmid= 10427470 |doi=
*cite journal | author=Lin L, Xu B, Rote NS |title=The cellular mechanism by which the human endogenous retrovirus ERV-3 env gene affects proliferation and differentiation in a human placental trophoblast model, BeWo. |journal=Placenta |volume=21 |issue= 1 |pages= 73–8 |year= 2000 |pmid= 10692254 |doi= 10.1053/plac.1999.0443
*cite journal | author=Kim H, Crow TJ, Hyun BH |title=Assignment of the endogenous retrovirus HERV-R (ERV3) to human chromosome 7q11.2 by radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=89 |issue= 1-2 |pages= 10 |year= 2000 |pmid= 10894926 |doi=
*cite journal | author=Andersson AC, Venables PJ, Tönjes RR, "et al." |title=Developmental expression of HERV-R (ERV3) and HERV-K in human tissue. |journal=Virology |volume=297 |issue= 2 |pages= 220–5 |year= 2002 |pmid= 12083821 |doi=
*cite journal | author=Hillier LW, Fulton RS, Fulton LA, "et al." |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157–64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782

External links

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