TEK tyrosine kinase

TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal), also known as TEK, is a human gene.

TEK has also recently been designated CD202B (cluster of differentiation 202B).

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summary_text = The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase. [cite web | title = Entrez Gene: TEK TEK tyrosine kinase, endothelial (venous malformations, multiple cutaneous and mucosal)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7010| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Partanen J, Armstrong E, Mäkelä TP, "et al." |title=A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. |journal=Mol. Cell. Biol. |volume=12 |issue= 4 |pages= 1698–707 |year= 1992 |pmid= 1312667 |doi=
*cite journal | author=Huang L, Turck CW, Rao P, Peters KG |title=GRB2 and SH-PTP2: potentially important endothelial signaling molecules downstream of the TEK/TIE2 receptor tyrosine kinase. |journal=Oncogene |volume=11 |issue= 10 |pages= 2097–103 |year= 1995 |pmid= 7478529 |doi=
*cite journal | author=Deans JP, Kalt L, Ledbetter JA, "et al." |title=Association of 75/80-kDa phosphoproteins and the tyrosine kinases Lyn, Fyn, and Lck with the B cell molecule CD20. Evidence against involvement of the cytoplasmic regions of CD20. |journal=J. Biol. Chem. |volume=270 |issue= 38 |pages= 22632–8 |year= 1995 |pmid= 7545683 |doi=
*cite journal | author=Gallione CJ, Pasyk KA, Boon LM, "et al." |title=A gene for familial venous malformations maps to chromosome 9p in a second large kindred. |journal=J. Med. Genet. |volume=32 |issue= 3 |pages= 197–9 |year= 1995 |pmid= 7783168 |doi=
*cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, "et al." |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42–50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457
*cite journal | author=Boon LM, Mulliken JB, Vikkula M, "et al." |title=Assignment of a locus for dominantly inherited venous malformations to chromosome 9p. |journal=Hum. Mol. Genet. |volume=3 |issue= 9 |pages= 1583–7 |year= 1995 |pmid= 7833915 |doi=
*cite journal | author=Dumont DJ, Anderson L, Breitman ML, Duncan AM |title=Assignment of the endothelial-specific protein receptor tyrosine kinase gene (TEK) to human chromosome 9p21. |journal=Genomics |volume=23 |issue= 2 |pages= 512–3 |year= 1995 |pmid= 7835909 |doi= 10.1006/geno.1994.1536
*cite journal | author=Ziegler SF, Bird TA, Schneringer JA, "et al." |title=Molecular cloning and characterization of a novel receptor protein tyrosine kinase from human placenta. |journal=Oncogene |volume=8 |issue= 3 |pages= 663–70 |year= 1993 |pmid= 8382358 |doi=
*cite journal | author=Davis S, Aldrich TH, Jones PF, "et al." |title=Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. |journal=Cell |volume=87 |issue= 7 |pages= 1161–9 |year= 1997 |pmid= 8980223 |doi=
*cite journal | author=Suri C, Jones PF, Patan S, "et al." |title=Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. |journal=Cell |volume=87 |issue= 7 |pages= 1171–80 |year= 1997 |pmid= 8980224 |doi=
*cite journal | author=Vikkula M, Boon LM, Carraway KL, "et al." |title=Vascular dysmorphogenesis caused by an activating mutation in the receptor tyrosine kinase TIE2. |journal=Cell |volume=87 |issue= 7 |pages= 1181–90 |year= 1997 |pmid= 8980225 |doi=
*cite journal | author=Witzenbichler B, Maisonpierre PC, Jones P, "et al." |title=Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18514–21 |year= 1998 |pmid= 9660821 |doi=
*cite journal | author=Asahara T, Chen D, Takahashi T, "et al." |title=Tie2 receptor ligands, angiopoietin-1 and angiopoietin-2, modulate VEGF-induced postnatal neovascularization. |journal=Circ. Res. |volume=83 |issue= 3 |pages= 233–40 |year= 1998 |pmid= 9710115 |doi=
*cite journal | author=Sato A, Iwama A, Takakura N, "et al." |title=Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. |journal=Int. Immunol. |volume=10 |issue= 8 |pages= 1217–27 |year= 1998 |pmid= 9723709 |doi=
*cite journal | author=Jones N, Dumont DJ |title=The Tek/Tie2 receptor signals through a novel Dok-related docking protein, Dok-R. |journal=Oncogene |volume=17 |issue= 9 |pages= 1097–108 |year= 1998 |pmid= 9764820 |doi= 10.1038/sj.onc.1202115
*cite journal | author=De Sepulveda P, Okkenhaug K, Rose JL, "et al." |title=Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. |journal=EMBO J. |volume=18 |issue= 4 |pages= 904–15 |year= 1999 |pmid= 10022833 |doi= 10.1093/emboj/18.4.904
*cite journal | author=Valenzuela DM, Griffiths JA, Rojas J, "et al." |title=Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 1904–9 |year= 1999 |pmid= 10051567 |doi=
*cite journal | author=Calvert JT, Riney TJ, Kontos CD, "et al." |title=Allelic and locus heterogeneity in inherited venous malformations. |journal=Hum. Mol. Genet. |volume=8 |issue= 7 |pages= 1279–89 |year= 1999 |pmid= 10369874 |doi=
*cite journal | author=Jones N, Master Z, Jones J, "et al." |title=Identification of Tek/Tie2 binding partners. Binding to a multifunctional docking site mediates cell survival and migration. |journal=J. Biol. Chem. |volume=274 |issue= 43 |pages= 30896–905 |year= 1999 |pmid= 10521483 |doi=
*cite journal | author=Fachinger G, Deutsch U, Risau W |title=Functional interaction of vascular endothelial-protein-tyrosine phosphatase with the angiopoietin receptor Tie-2. |journal=Oncogene |volume=18 |issue= 43 |pages= 5948–53 |year= 1999 |pmid= 10557082 |doi= 10.1038/sj.onc.1202992

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