ITK (gene)

IL2-inducible T-cell kinase, also known as ITK, is a human gene.cite journal | author = Gibson S, Leung B, Squire JA, Hill M, Arima N, Goss P, Hogg D, Mills GB | title = Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q | journal = Blood | volume = 82 | issue = 5 | pages = 1561–72 | year = 1993 | month = September | pmid = 8364206 | doi = | url = http://bloodjournal.hematologylibrary.org/cgi/content/abstract/bloodjournal;82/5/1561 | issn = ]

This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains SH2, SH3 and PH domains which are often found in intracellular kinases.cite journal | author = Hawkins J, Marcy A | title = Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activity | journal = Protein Expr. Purif. | volume = 22 | issue = 2 | pages = 211–9 | year = 2001 | month = July | pmid = 11437596 | doi = 10.1006/prep.2001.1447 | url = | issn = ] It is thought to play a role in T-cell proliferation and differentiation.cite journal | author = Kosaka Y, Felices M, Berg LJ | title = Itk and Th2 responses: action but no reaction | journal = Trends Immunol. | volume = 27 | issue = 10 | pages = 453–60 | year = 2006 | month = October | pmid = 16931156 | doi = 10.1016/j.it.2006.08.006 | url = | issn = ] [cite web | title = Entrez Gene: ITK IL2-inducible T-cell kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3702| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Kosaka Y, Felices M, Berg LJ |title=Itk and Th2 responses: action but no reaction. |journal=Trends Immunol. |volume=27 |issue= 10 |pages= 453–60 |year= 2006 |pmid= 16931156 |doi= 10.1016/j.it.2006.08.006
*cite journal | author=Langhans-Rajasekaran SA, Wan Y, Huang XY |title=Activation of Tsk and Btk tyrosine kinases by G protein beta gamma subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 19 |pages= 8601–5 |year= 1995 |pmid= 7567982 |doi=
*cite journal | author=Janis EM, Siliciano JD, Isaac DD, "et al." |title=Mapping of the gene for the tyrosine kinase Itk to a region of conserved synteny between mouse chromosome 11 and human chromosome 5q. |journal=Genomics |volume=23 |issue= 1 |pages= 269–71 |year= 1995 |pmid= 7829087 |doi=
*cite journal | author=Gibson S, Leung B, Squire JA, "et al." |title=Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q. |journal=Blood |volume=82 |issue= 5 |pages= 1561–72 |year= 1993 |pmid= 8364206 |doi=
*cite journal | author=Tanaka N, Asao H, Ohtani K, "et al." |title=A novel human tyrosine kinase gene inducible in T cells by interleukin 2. |journal=FEBS Lett. |volume=324 |issue= 1 |pages= 1–5 |year= 1993 |pmid= 8504851 |doi=
*cite journal | author=Rawlings DJ, Scharenberg AM, Park H, "et al." |title=Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. |journal=Science |volume=271 |issue= 5250 |pages= 822–5 |year= 1996 |pmid= 8629002 |doi=
*cite journal | author=Park H, Wahl MI, Afar DE, "et al." |title=Regulation of Btk function by a major autophosphorylation site within the SH3 domain. |journal=Immunity |volume=4 |issue= 5 |pages= 515–25 |year= 1996 |pmid= 8630736 |doi=
*cite journal | author=Bunnell SC, Henry PA, Kolluri R, "et al." |title=Identification of Itk/Tsk Src homology 3 domain ligands. |journal=J. Biol. Chem. |volume=271 |issue= 41 |pages= 25646–56 |year= 1996 |pmid= 8810341 |doi=
*cite journal | author=Andreotti AH, Bunnell SC, Feng S, "et al." |title=Regulatory intramolecular association in a tyrosine kinase of the Tec family. |journal=Nature |volume=385 |issue= 6611 |pages= 93–7 |year= 1997 |pmid= 8985255 |doi= 10.1038/385093a0
*cite journal | author=King PD, Sadra A, Teng JM, "et al." |title=Analysis of CD28 cytoplasmic tail tyrosine residues as regulators and substrates for the protein tyrosine kinases, EMT and LCK. |journal=J. Immunol. |volume=158 |issue= 2 |pages= 580–90 |year= 1997 |pmid= 8992971 |doi=
*cite journal | author=Heyeck SD, Wilcox HM, Bunnell SC, Berg LJ |title=Lck phosphorylates the activation loop tyrosine of the Itk kinase domain and activates Itk kinase activity. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 25401–8 |year= 1997 |pmid= 9312162 |doi=
*cite journal | author=De Sepulveda P, Okkenhaug K, Rose JL, "et al." |title=Socs1 binds to multiple signalling proteins and suppresses steel factor-dependent proliferation. |journal=EMBO J. |volume=18 |issue= 4 |pages= 904–15 |year= 1999 |pmid= 10022833 |doi= 10.1093/emboj/18.4.904
*cite journal | author=Kaukonen J, Savolainen ER, Palotie A |title=Human Emt tyrosine kinase is specifically expressed both in mature T-lymphocytes and T-cell associated hematopoietic malignancies. |journal=Leuk. Lymphoma |volume=32 |issue= 5-6 |pages= 513–22 |year= 1999 |pmid= 10048424 |doi=
*cite journal | author=Shan X, Wange RL |title=Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment. |journal=J. Biol. Chem. |volume=274 |issue= 41 |pages= 29323–30 |year= 1999 |pmid= 10506192 |doi=
*cite journal | author=Su YW, Zhang Y, Schweikert J, "et al." |title=Interaction of SLP adaptors with the SH2 domain of Tec family kinases. |journal=Eur. J. Immunol. |volume=29 |issue= 11 |pages= 3702–11 |year= 1999 |pmid= 10556826 |doi=
*cite journal | author=Perez-Villar JJ, Kanner SB |title=Regulated association between the tyrosine kinase Emt/Itk/Tsk and phospholipase-C gamma 1 in human T lymphocytes. |journal=J. Immunol. |volume=163 |issue= 12 |pages= 6435–41 |year= 2000 |pmid= 10586033 |doi=
*cite journal | author=Rajagopal K, Sommers CL, Decker DC, "et al." |title=RIBP, a novel Rlk/Txk- and itk-binding adaptor protein that regulates T cell activation. |journal=J. Exp. Med. |volume=190 |issue= 11 |pages= 1657–68 |year= 2000 |pmid= 10587356 |doi=
*cite journal | author=Bunnell SC, Diehn M, Yaffe MB, "et al." |title=Biochemical interactions integrating Itk with the T cell receptor-initiated signaling cascade. |journal=J. Biol. Chem. |volume=275 |issue= 3 |pages= 2219–30 |year= 2000 |pmid= 10636929 |doi=
*cite journal | author=Shan X, Czar MJ, Bunnell SC, "et al." |title=Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation. |journal=Mol. Cell. Biol. |volume=20 |issue= 18 |pages= 6945–57 |year= 2000 |pmid= 10958690 |doi=
*cite journal | author=Hawkins J, Marcy A |title=Characterization of Itk tyrosine kinase: contribution of noncatalytic domains to enzymatic activity. |journal=Protein Expr. Purif. |volume=22 |issue= 2 |pages= 211–9 |year= 2001 |pmid= 11437596 |doi= 10.1006/prep.2001.1447

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