- BMX (gene)
BMX non-receptor tyrosine kinase, also known as BMX, is a human
gene .cite web | title = Entrez Gene: BMX BMX non-receptor tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=660| accessdate = ]PBB_Summary
section_title =
summary_text = Tyrosine kinases are either receptor molecules, which contain transmembrane and extracellular domains, or nonreceptor proteins, which are located intracellularly. One family of nonreceptor TKs includes the genes TEC (MIM 600583), TXK (MIM 600058), ITK (MIM 186973), and BTK (MIM 300300). All of these proteins are homologs of the Drosophila Src28 TK and contain an SH3 and SH2 domain upstream of the TK domain. [supplied by OMIM] cite web | title = Entrez Gene: BMX BMX non-receptor tyrosine kinase| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=660| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Tamagnone L, Lahtinen I, Mustonen T, "et al." |title=BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2. |journal=Oncogene |volume=9 |issue= 12 |pages= 3683–8 |year= 1994 |pmid= 7970727 |doi=
*cite journal | author=Robinson D, He F, Pretlow T, Kung HJ |title=A tyrosine kinase profile of prostate carcinoma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 12 |pages= 5958–62 |year= 1996 |pmid= 8650201 |doi=
*cite journal | author=Kaukonen J, Lahtinen I, Laine S, "et al." |title=BMX tyrosine kinase gene is expressed in granulocytes and myeloid leukaemias. |journal=Br. J. Haematol. |volume=94 |issue= 3 |pages= 455–60 |year= 1996 |pmid= 8790141 |doi=
*cite journal | author=Ekman N, Lymboussaki A, Västrik I, "et al." |title=Bmx tyrosine kinase is specifically expressed in the endocardium and the endothelium of large arteries. |journal=Circulation |volume=96 |issue= 6 |pages= 1729–32 |year= 1997 |pmid= 9323053 |doi=
*cite journal | author=Saharinen P, Ekman N, Sarvas K, "et al." |title=The Bmx tyrosine kinase induces activation of the Stat signaling pathway, which is specifically inhibited by protein kinase Cdelta. |journal=Blood |volume=90 |issue= 11 |pages= 4341–53 |year= 1997 |pmid= 9373245 |doi=
*cite journal | author=Qiu Y, Robinson D, Pretlow TG, Kung HJ |title=Etk/Bmx, a tyrosine kinase with a pleckstrin-homology domain, is an effector of phosphatidylinositol 3'-kinase and is involved in interleukin 6-induced neuroendocrine differentiation of prostate cancer cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 7 |pages= 3644–9 |year= 1998 |pmid= 9520419 |doi=
*cite journal | author=Várnai P, Rother KI, Balla T |title=Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells. |journal=J. Biol. Chem. |volume=274 |issue= 16 |pages= 10983–9 |year= 1999 |pmid= 10196179 |doi=
*cite journal | author=Tsai YT, Su YH, Fang SS, "et al." |title=Etk, a Btk family tyrosine kinase, mediates cellular transformation by linking Src to STAT3 activation. |journal=Mol. Cell. Biol. |volume=20 |issue= 6 |pages= 2043–54 |year= 2000 |pmid= 10688651 |doi=
*cite journal | author=Ekman N, Arighi E, Rajantie I, "et al." |title=The Bmx tyrosine kinase is activated by IL-3 and G-CSF in a PI-3K dependent manner. |journal=Oncogene |volume=19 |issue= 36 |pages= 4151–8 |year= 2000 |pmid= 10962576 |doi= 10.1038/sj.onc.1203763
*cite journal | author=Jui HY, Tseng RJ, Wen X, "et al." |title=Protein-tyrosine phosphatase D1, a potential regulator and effector for Tec family kinases. |journal=J. Biol. Chem. |volume=275 |issue= 52 |pages= 41124–32 |year= 2001 |pmid= 11013262 |doi= 10.1074/jbc.M007772200
*cite journal | author=Wu YM, Huang CL, Kung HJ, Huang CY |title=Proteolytic activation of ETK/Bmx tyrosine kinase by caspases. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 17672–8 |year= 2001 |pmid= 11278797 |doi= 10.1074/jbc.M010964200
*cite journal | author=Chen R, Kim O, Li M, "et al." |title=Regulation of the PH-domain-containing tyrosine kinase Etk by focal adhesion kinase through the FERM domain. |journal=Nat. Cell Biol. |volume=3 |issue= 5 |pages= 439–44 |year= 2001 |pmid= 11331870 |doi= 10.1038/35074500
*cite journal | author=Bagheri-Yarmand R, Mandal M, Taludker AH, "et al." |title=Etk/Bmx tyrosine kinase activates Pak1 and regulates tumorigenicity of breast cancer cells. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 29403–9 |year= 2001 |pmid= 11382770 |doi= 10.1074/jbc.M103129200
*cite journal | author=Vargas L, Nore BF, Berglof A, "et al." |title=Functional interaction of caveolin-1 with Bruton's tyrosine kinase and Bmx. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9351–7 |year= 2002 |pmid= 11751885 |doi= 10.1074/jbc.M108537200
*cite journal | author=Yang J, Kim O, Wu J, Qiu Y |title=Interaction between tyrosine kinase Etk and a RUN domain- and FYVE domain-containing protein RUFY1. A possible role of ETK in regulation of vesicle trafficking. |journal=J. Biol. Chem. |volume=277 |issue= 33 |pages= 30219–26 |year= 2002 |pmid= 11877430 |doi= 10.1074/jbc.M111933200
*cite journal | author=Pan S, An P, Zhang R, "et al." |title=Etk/Bmx as a tumor necrosis factor receptor type 2-specific kinase: role in endothelial cell migration and angiogenesis. |journal=Mol. Cell. Biol. |volume=22 |issue= 21 |pages= 7512–23 |year= 2002 |pmid= 12370298 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Nore BF, Mattsson PT, Antonsson P, "et al." |title=Identification of phosphorylation sites within the SH3 domains of Tec family tyrosine kinases. |journal=Biochim. Biophys. Acta |volume=1645 |issue= 2 |pages= 123–32 |year= 2003 |pmid= 12573241 |doi=
*cite journal | author=Zhang R, Xu Y, Ekman N, "et al." |title=Etk/Bmx transactivates vascular endothelial growth factor 2 and recruits phosphatidylinositol 3-kinase to mediate the tumor necrosis factor-induced angiogenic pathway. |journal=J. Biol. Chem. |volume=278 |issue= 51 |pages= 51267–76 |year= 2004 |pmid= 14532277 |doi= 10.1074/jbc.M310678200
*cite journal | author=Chen KY, Huang LM, Kung HJ, "et al." |title=The role of tyrosine kinase Etk/Bmx in EGF-induced apoptosis of MDA-MB-468 breast cancer cells. |journal=Oncogene |volume=23 |issue= 10 |pages= 1854–62 |year= 2004 |pmid= 14676838 |doi= 10.1038/sj.onc.1207308PBB_Controls
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