PTK6

PTK6 protein tyrosine kinase 6, also known as PTK6, is a human gene.cite web | title = Entrez Gene: PTK6 PTK6 protein tyrosine kinase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5753| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a cytoplasmic nonreceptor protein kinase which may function as an intracellular signal transducer in epithelial tissues. Overexpression of this gene in mammary epithelial cells leads to sensitization of the cells to epidermal growth factor and results in a partially transformed phenotype. Expression of this gene has been detected at low levels in some breast tumors but not in normal breast tissue. The encoded protein has been shown to undergo autophosphorylation.cite web | title = Entrez Gene: PTK6 PTK6 protein tyrosine kinase 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5753| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Serfas MS, Tyner AL |title=Brk, Srm, Frk, and Src42A form a distinct family of intracellular Src-like tyrosine kinases. |journal=Oncol. Res. |volume=13 |issue= 6-10 |pages= 409–19 |year= 2003 |pmid= 12725532 |doi=
*cite journal | author=Mitchell PJ, Barker KT, Martindale JE, "et al." |title=Cloning and characterisation of cDNAs encoding a novel non-receptor tyrosine kinase, brk, expressed in human breast tumours. |journal=Oncogene |volume=9 |issue= 8 |pages= 2383–90 |year= 1994 |pmid= 8036022 |doi=
*cite journal | author=Lee ST, Strunk KM, Spritz RA |title=A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes. |journal=Oncogene |volume=8 |issue= 12 |pages= 3403–10 |year= 1993 |pmid= 8247543 |doi=
*cite journal | author=Kamalati T, Jolin HE, Mitchell PJ, "et al." |title=Brk, a breast tumor-derived non-receptor protein-tyrosine kinase, sensitizes mammary epithelial cells to epidermal growth factor. |journal=J. Biol. Chem. |volume=271 |issue= 48 |pages= 30956–63 |year= 1997 |pmid= 8940083 |doi=
*cite journal | author=Park SH, Lee KH, Kim H, Lee ST |title=Assignment of the human PTK6 gene encoding a non-receptor protein tyrosine kinase to 20q13.3 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 271–2 |year= 1997 |pmid= 9284935 |doi=
*cite journal | author=Lee H, Kim M, Lee KH, "et al." |title=Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase. |journal=Mol. Cells |volume=8 |issue= 4 |pages= 401–7 |year= 1998 |pmid= 9749526 |doi=
*cite journal | author=Llor X, Serfas MS, Bie W, "et al." |title=BRK/Sik expression in the gastrointestinal tract and in colon tumors. |journal=Clin. Cancer Res. |volume=5 |issue= 7 |pages= 1767–77 |year= 1999 |pmid= 10430081 |doi=
*cite journal | author=Derry JJ, Richard S, Valderrama Carvajal H, "et al." |title=Sik (BRK) phosphorylates Sam68 in the nucleus and negatively regulates its RNA binding ability. |journal=Mol. Cell. Biol. |volume=20 |issue= 16 |pages= 6114–26 |year= 2000 |pmid= 10913193 |doi=
*cite journal | author=Mitchell PJ, Sara EA, Crompton MR |title=A novel adaptor-like protein which is a substrate for the non-receptor tyrosine kinase, BRK. |journal=Oncogene |volume=19 |issue= 37 |pages= 4273–82 |year= 2000 |pmid= 10980601 |doi= 10.1038/sj.onc.1203775
*cite journal | author=Kamalati T, Jolin HE, Fry MJ, Crompton MR |title=Expression of the BRK tyrosine kinase in mammary epithelial cells enhances the coupling of EGF signalling to PI 3-kinase and Akt, via erbB3 phosphorylation. |journal=Oncogene |volume=19 |issue= 48 |pages= 5471–6 |year= 2000 |pmid= 11114724 |doi= 10.1038/sj.onc.1203931
*cite journal | author=Hong E, Shin J, Bang E, "et al." |title=Complete sequence-specific 1H, 13C and 15N resonance assignments of the human PTK6 SH2 domain. |journal=J. Biomol. NMR |volume=19 |issue= 3 |pages= 291–2 |year= 2001 |pmid= 11330822 |doi=
*cite journal | author=Deloukas P, Matthews LH, Ashurst J, "et al." |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865–71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a
*cite journal | author=Kang KN, Kim M, Pae KM, Lee ST |title=Characterization of the 5'-flanking region of the human PTK6 gene. |journal=Biochim. Biophys. Acta |volume=1574 |issue= 3 |pages= 365–9 |year= 2002 |pmid= 11997104 |doi=
*cite journal | author=Qiu H, Miller WT |title=Regulation of the nonreceptor tyrosine kinase Brk by autophosphorylation and by autoinhibition. |journal=J. Biol. Chem. |volume=277 |issue= 37 |pages= 34634–41 |year= 2002 |pmid= 12121988 |doi= 10.1074/jbc.M203877200
*cite journal | author=Koo BK, Kim MH, Lee ST, Lee W |title=Purification and spectroscopic characterization of the human protein tyrosine kinase-6 SH3 domain. |journal=J. Biochem. Mol. Biol. |volume=35 |issue= 3 |pages= 343–7 |year= 2002 |pmid= 12297019 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Coyle JH, Guzik BW, Bor YC, "et al." |title=Sam68 enhances the cytoplasmic utilization of intron-containing RNA and is functionally regulated by the nuclear kinase Sik/BRK. |journal=Mol. Cell. Biol. |volume=23 |issue= 1 |pages= 92–103 |year= 2003 |pmid= 12482964 |doi=
*cite journal | author=Derry JJ, Prins GS, Ray V, Tyner AL |title=Altered localization and activity of the intracellular tyrosine kinase BRK/Sik in prostate tumor cells. |journal=Oncogene |volume=22 |issue= 27 |pages= 4212–20 |year= 2003 |pmid= 12833144 |doi= 10.1038/sj.onc.1206465
*cite journal | author=Qiu H, Miller WT |title=Role of the Brk SH3 domain in substrate recognition. |journal=Oncogene |volume=23 |issue= 12 |pages= 2216–23 |year= 2004 |pmid= 14676834 |doi= 10.1038/sj.onc.1207339

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes