EPHB6

EPH receptor B6, also known as EPHB6, is a human gene.cite web | title = Entrez Gene: EPHB6 EPH receptor B6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2051| accessdate = ]

PBB_Summary
section_title =
summary_text = Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands.cite web | title = Entrez Gene: EPHB6 EPH receptor B6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2051| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Flanagan JG, Vanderhaeghen P |title=The ephrins and Eph receptors in neural development. |journal=Annu. Rev. Neurosci. |volume=21 |issue= |pages= 309–45 |year= 1998 |pmid= 9530499 |doi= 10.1146/annurev.neuro.21.1.309
*cite journal | author=Zhou R |title=The Eph family receptors and ligands. |journal=Pharmacol. Ther. |volume=77 |issue= 3 |pages= 151–81 |year= 1998 |pmid= 9576626 |doi=
*cite journal | author=Holder N, Klein R |title=Eph receptors and ephrins: effectors of morphogenesis. |journal=Development |volume=126 |issue= 10 |pages= 2033–44 |year= 1999 |pmid= 10207129 |doi=
*cite journal | author=Wilkinson DG |title=Eph receptors and ephrins: regulators of guidance and assembly. |journal=Int. Rev. Cytol. |volume=196 |issue= |pages= 177–244 |year= 2000 |pmid= 10730216 |doi=
*cite journal | author=Xu Q, Mellitzer G, Wilkinson DG |title=Roles of Eph receptors and ephrins in segmental patterning. |journal=Philos. Trans. R. Soc. Lond., B, Biol. Sci. |volume=355 |issue= 1399 |pages= 993–1002 |year= 2001 |pmid= 11128993 |doi= 10.1098/rstb.2000.0635
*cite journal | author=Wilkinson DG |title=Multiple roles of EPH receptors and ephrins in neural development. |journal=Nat. Rev. Neurosci. |volume=2 |issue= 3 |pages= 155–64 |year= 2001 |pmid= 11256076 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Matsuoka H, Iwata N, Ito M, "et al." |title=Expression of a kinase-defective Eph-like receptor in the normal human brain. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 3 |pages= 487–92 |year= 1997 |pmid= 9207182 |doi= 10.1006/bbrc.1997.6812
*cite journal | author= |title=Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee. |journal=Cell |volume=90 |issue= 3 |pages= 403–4 |year= 1997 |pmid= 9267020 |doi=
*cite journal | author=Hock B, Böhme B, Karn T, "et al." |title=PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 17 |pages= 9779–84 |year= 1998 |pmid= 9707552 |doi=
*cite journal | author=Munthe E, Rian E, Holien T, "et al." |title=Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6. |journal=FEBS Lett. |volume=466 |issue= 1 |pages= 169–74 |year= 2000 |pmid= 10648835 |doi=
*cite journal | author=Shimoyama M, Matsuoka H, Tamekane A, "et al." |title=T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells. |journal=Growth Factors |volume=18 |issue= 1 |pages= 63–78 |year= 2000 |pmid= 10831073 |doi=
*cite journal | author=Tang XX, Zhao H, Robinson ME, "et al." |title=Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 20 |pages= 10936–41 |year= 2000 |pmid= 10984508 |doi= 10.1073/pnas.190123297
*cite journal | author=Luo H, Wan X, Wu Y, Wu J |title=Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells. |journal=J. Immunol. |volume=167 |issue= 3 |pages= 1362–70 |year= 2001 |pmid= 11466354 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes