VEGF receptors

protein
Name= fms-related tyrosine kinase 1 (vascular endothelial growth factor/vascular permeability factor receptor)
caption=


width=
HGNCid=3763
Symbol=FLT1
AltSymbols=FLT
EntrezGene=2321
OMIM=165070
RefSeq=NM_002019
UniProt=P17948
PDB=
ECnumber=2.7.1.112
Chromosome=13
Arm=q
Band=12
LocusSupplementaryData=protein
Name=kinase insert domain receptor (a type III receptor tyrosine kinase)
caption=


width=
HGNCid=6307
Symbol=KDR
AltSymbols=FLK1, VEGFR, VEGFR2, CD309
EntrezGene=3791
OMIM=191306
RefSeq=NM_002253
UniProt=P35968
PDB=
ECnumber=2.7.1.112
Chromosome=4
Arm=q
Band=11
LocusSupplementaryData=-q12protein
Name= fms-related tyrosine kinase 4
caption=


width=
HGNCid=3767
Symbol=FLT4
AltSymbols=VEGFR3, PCL
EntrezGene=2324
OMIM=136352
RefSeq=NM_002020
UniProt=P35916
PDB=
ECnumber=2.7.1.112
Chromosome=5
Arm=q
Band=34
LocusSupplementaryData=-q35

VEGF receptors are receptors for Vascular Endothelial Growth Factor (VEGF).

VEGF

Vascular endothelial growth factor (VEGF) is an important signaling protein involved in both vasculogenesis (the formation of the embryonic circulatory system) and angiogenesis (the growth of blood vessels from pre-existing vasculature). As its name implies, VEGF activity is restricted mainly to cells of the vascular endothelium, although it does have effects on a limited number of other cell types (e.g. stimulation monocyte/macrophage migration). "In vitro", VEGF has been shown to stimulate endothelial cell mitogenesis and cell migration. VEGF also enhances microvascular permeability and is sometimes referred to as vascular permeability factor.

Receptor biology

All members of the VEGF family stimulate cellular responses by binding to tyrosine kinase receptors (the VEGFRs) on the cell surface, causing them to dimerize and become activated through transphosphorylation. The VEGF receptors have an extracellular portion consisting of 7 immunoglobulin-like domains, a single transmembrane spanning region and an intracellular portion containing a split tyrosine-kinase domain. VEGF-A binds to VEGFR-1 (Flt-1) and VEGFR-2 (KDR/Flk-1). VEGFR-2 appears to mediate almost all of the known cellular responses to VEGF. The function of VEGFR-1 is less well defined, although it is thought to modulate VEGFR-2 signaling. Another function of VEGFR-1 may be to act as a dummy/decoy receptor, sequestering VEGF from VEGFR-2 binding (this appears to be particularly important during vasculogenesis in the embryo). A third receptor has been discovered (VEGFR-3), however, VEGF-A is not a ligand for this receptor. VEGFR-3 mediates lymphangiogenesis in response to VEGF-C and VEGF-D.

References

External links

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