- NTRK2
Neurotrophic tyrosine kinase, receptor, type 2, also known as NTRK2, is a human
gene .PBB_Summary
section_title =
summary_text = This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [cite web | title = Entrez Gene: NTRK2 neurotrophic tyrosine kinase, receptor, type 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4915| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Yamada K, Nabeshima T |title=Brain-derived neurotrophic factor/TrkB signaling in memory processes. |journal=J. Pharmacol. Sci. |volume=91 |issue= 4 |pages= 267–70 |year= 2004 |pmid= 12719654 |doi=
*cite journal | author=Soppet D, Escandon E, Maragos J, "et al." |title=The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. |journal=Cell |volume=65 |issue= 5 |pages= 895–903 |year= 1991 |pmid= 1645620 |doi=
*cite journal | author=Squinto SP, Stitt TN, Aldrich TH, "et al." |title=trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. |journal=Cell |volume=65 |issue= 5 |pages= 885–93 |year= 1991 |pmid= 1710174 |doi=
*cite journal | author=Haniu M, Talvenheimo J, Le J, "et al." |title=Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding. |journal=Arch. Biochem. Biophys. |volume=322 |issue= 1 |pages= 256–64 |year= 1995 |pmid= 7574684 |doi= 10.1006/abbi.1995.1460
*cite journal | author=Ip NY, Stitt TN, Tapley P, "et al." |title=Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. |journal=Neuron |volume=10 |issue= 2 |pages= 137–49 |year= 1993 |pmid= 7679912 |doi=
*cite journal | author=Slaugenhaupt SA, Blumenfeld A, Liebert CB, "et al." |title=The human gene for neurotrophic tyrosine kinase receptor type 2 (NTRK2) is located on chromosome 9 but is not the familial dysautonomia gene. |journal=Genomics |volume=25 |issue= 3 |pages= 730–2 |year= 1995 |pmid= 7759111 |doi=
*cite journal | author=Nakagawara A, Liu XG, Ikegaki N, "et al." |title=Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2). |journal=Genomics |volume=25 |issue= 2 |pages= 538–46 |year= 1995 |pmid= 7789988 |doi=
*cite journal | author=Shelton DL, Sutherland J, Gripp J, "et al." |title=Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. |journal=J. Neurosci. |volume=15 |issue= 1 Pt 2 |pages= 477–91 |year= 1995 |pmid= 7823156 |doi=
*cite journal | author=Allen SJ, Dawbarn D, Eckford SD, "et al." |title=Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain. |journal=Neuroscience |volume=60 |issue= 3 |pages= 825–34 |year= 1994 |pmid= 7936202 |doi=
*cite journal | author=Rydén M, Ibáñez CF |title=Binding of neurotrophin-3 to p75LNGFR, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by trkC. |journal=J. Biol. Chem. |volume=271 |issue= 10 |pages= 5623–7 |year= 1996 |pmid= 8621424 |doi=
*cite journal | author=Yamamoto M, Sobue G, Yamamoto K, "et al." |title=Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues. |journal=Neurochem. Res. |volume=21 |issue= 8 |pages= 929–38 |year= 1997 |pmid= 8895847 |doi=
*cite journal | author=Valent A, Danglot G, Bernheim A |title=Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization. |journal=Eur. J. Hum. Genet. |volume=5 |issue= 2 |pages= 102–4 |year= 1997 |pmid= 9195161 |doi=
*cite journal | author=Haniu M, Montestruque S, Bures EJ, "et al." |title=Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 25296–303 |year= 1997 |pmid= 9312147 |doi=
*cite journal | author=Nakamura T, Muraoka S, Sanokawa R, Mori N |title=N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6960–7 |year= 1998 |pmid= 9507002 |doi=
*cite journal | author=Hackett SF, Friedman Z, Freund J, "et al." |title=A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics. |journal=Brain Res. |volume=789 |issue= 2 |pages= 201–12 |year= 1998 |pmid= 9573364 |doi=
*cite journal | author=Iwasaki Y, Gay B, Wada K, Koizumi S |title=Association of the Src family tyrosine kinase Fyn with TrkB. |journal=J. Neurochem. |volume=71 |issue= 1 |pages= 106–11 |year= 1998 |pmid= 9648856 |doi=
*cite journal | author=Qian X, Riccio A, Zhang Y, Ginty DD |title=Identification and characterization of novel substrates of Trk receptors in developing neurons. |journal=Neuron |volume=21 |issue= 5 |pages= 1017–29 |year= 1999 |pmid= 9856458 |doi=
*cite journal | author=Bibel M, Hoppe E, Barde YA |title=Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. |journal=EMBO J. |volume=18 |issue= 3 |pages= 616–22 |year= 1999 |pmid= 9927421 |doi= 10.1093/emboj/18.3.616
*cite journal | author=Yamada M, Ohnishi H, Sano S, "et al." |title=Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons. |journal=J. Neurochem. |volume=73 |issue= 1 |pages= 41–9 |year= 1999 |pmid= 10386953 |doi=
*cite journal | author=Ultsch MH, Wiesmann C, Simmons LC, "et al." |title=Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC. |journal=J. Mol. Biol. |volume=290 |issue= 1 |pages= 149–59 |year= 1999 |pmid= 10388563 |doi= 10.1006/jmbi.1999.2816PBB_Controls
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