NTRK2

NTRK2

Neurotrophic tyrosine kinase, receptor, type 2, also known as NTRK2, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane-bound receptor that, upon neurotrophin binding, phosphorylates itself and members of the MAPK pathway. Signalling through this kinase leads to cell differentiation. Mutations in this gene have been associated with obesity and mood disorders. Alternate transcriptional splice variants encoding different isoforms have been found for this gene. [cite web | title = Entrez Gene: NTRK2 neurotrophic tyrosine kinase, receptor, type 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4915| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Yamada K, Nabeshima T |title=Brain-derived neurotrophic factor/TrkB signaling in memory processes. |journal=J. Pharmacol. Sci. |volume=91 |issue= 4 |pages= 267–70 |year= 2004 |pmid= 12719654 |doi=
*cite journal | author=Soppet D, Escandon E, Maragos J, "et al." |title=The neurotrophic factors brain-derived neurotrophic factor and neurotrophin-3 are ligands for the trkB tyrosine kinase receptor. |journal=Cell |volume=65 |issue= 5 |pages= 895–903 |year= 1991 |pmid= 1645620 |doi=
*cite journal | author=Squinto SP, Stitt TN, Aldrich TH, "et al." |title=trkB encodes a functional receptor for brain-derived neurotrophic factor and neurotrophin-3 but not nerve growth factor. |journal=Cell |volume=65 |issue= 5 |pages= 885–93 |year= 1991 |pmid= 1710174 |doi=
*cite journal | author=Haniu M, Talvenheimo J, Le J, "et al." |title=Extracellular domain of neurotrophin receptor trkB: disulfide structure, N-glycosylation sites, and ligand binding. |journal=Arch. Biochem. Biophys. |volume=322 |issue= 1 |pages= 256–64 |year= 1995 |pmid= 7574684 |doi= 10.1006/abbi.1995.1460
*cite journal | author=Ip NY, Stitt TN, Tapley P, "et al." |title=Similarities and differences in the way neurotrophins interact with the Trk receptors in neuronal and nonneuronal cells. |journal=Neuron |volume=10 |issue= 2 |pages= 137–49 |year= 1993 |pmid= 7679912 |doi=
*cite journal | author=Slaugenhaupt SA, Blumenfeld A, Liebert CB, "et al." |title=The human gene for neurotrophic tyrosine kinase receptor type 2 (NTRK2) is located on chromosome 9 but is not the familial dysautonomia gene. |journal=Genomics |volume=25 |issue= 3 |pages= 730–2 |year= 1995 |pmid= 7759111 |doi=
*cite journal | author=Nakagawara A, Liu XG, Ikegaki N, "et al." |title=Cloning and chromosomal localization of the human TRK-B tyrosine kinase receptor gene (NTRK2). |journal=Genomics |volume=25 |issue= 2 |pages= 538–46 |year= 1995 |pmid= 7789988 |doi=
*cite journal | author=Shelton DL, Sutherland J, Gripp J, "et al." |title=Human trks: molecular cloning, tissue distribution, and expression of extracellular domain immunoadhesins. |journal=J. Neurosci. |volume=15 |issue= 1 Pt 2 |pages= 477–91 |year= 1995 |pmid= 7823156 |doi=
*cite journal | author=Allen SJ, Dawbarn D, Eckford SD, "et al." |title=Cloning of a non-catalytic form of human trkB and distribution of messenger RNA for trkB in human brain. |journal=Neuroscience |volume=60 |issue= 3 |pages= 825–34 |year= 1994 |pmid= 7936202 |doi=
*cite journal | author=Rydén M, Ibáñez CF |title=Binding of neurotrophin-3 to p75LNGFR, TrkA, and TrkB mediated by a single functional epitope distinct from that recognized by trkC. |journal=J. Biol. Chem. |volume=271 |issue= 10 |pages= 5623–7 |year= 1996 |pmid= 8621424 |doi=
*cite journal | author=Yamamoto M, Sobue G, Yamamoto K, "et al." |title=Expression of mRNAs for neurotrophic factors (NGF, BDNF, NT-3, and GDNF) and their receptors (p75NGFR, trkA, trkB, and trkC) in the adult human peripheral nervous system and nonneural tissues. |journal=Neurochem. Res. |volume=21 |issue= 8 |pages= 929–38 |year= 1997 |pmid= 8895847 |doi=
*cite journal | author=Valent A, Danglot G, Bernheim A |title=Mapping of the tyrosine kinase receptors trkA (NTRK1), trkB (NTRK2) and trkC(NTRK3) to human chromosomes 1q22, 9q22 and 15q25 by fluorescence in situ hybridization. |journal=Eur. J. Hum. Genet. |volume=5 |issue= 2 |pages= 102–4 |year= 1997 |pmid= 9195161 |doi=
*cite journal | author=Haniu M, Montestruque S, Bures EJ, "et al." |title=Interactions between brain-derived neurotrophic factor and the TRKB receptor. Identification of two ligand binding domains in soluble TRKB by affinity separation and chemical cross-linking. |journal=J. Biol. Chem. |volume=272 |issue= 40 |pages= 25296–303 |year= 1997 |pmid= 9312147 |doi=
*cite journal | author=Nakamura T, Muraoka S, Sanokawa R, Mori N |title=N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling. |journal=J. Biol. Chem. |volume=273 |issue= 12 |pages= 6960–7 |year= 1998 |pmid= 9507002 |doi=
*cite journal | author=Hackett SF, Friedman Z, Freund J, "et al." |title=A splice variant of trkB and brain-derived neurotrophic factor are co-expressed in retinal pigmented epithelial cells and promote differentiated characteristics. |journal=Brain Res. |volume=789 |issue= 2 |pages= 201–12 |year= 1998 |pmid= 9573364 |doi=
*cite journal | author=Iwasaki Y, Gay B, Wada K, Koizumi S |title=Association of the Src family tyrosine kinase Fyn with TrkB. |journal=J. Neurochem. |volume=71 |issue= 1 |pages= 106–11 |year= 1998 |pmid= 9648856 |doi=
*cite journal | author=Qian X, Riccio A, Zhang Y, Ginty DD |title=Identification and characterization of novel substrates of Trk receptors in developing neurons. |journal=Neuron |volume=21 |issue= 5 |pages= 1017–29 |year= 1999 |pmid= 9856458 |doi=
*cite journal | author=Bibel M, Hoppe E, Barde YA |title=Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. |journal=EMBO J. |volume=18 |issue= 3 |pages= 616–22 |year= 1999 |pmid= 9927421 |doi= 10.1093/emboj/18.3.616
*cite journal | author=Yamada M, Ohnishi H, Sano S, "et al." |title=Brain-derived neurotrophic factor stimulates interactions of Shp2 with phosphatidylinositol 3-kinase and Grb2 in cultured cerebral cortical neurons. |journal=J. Neurochem. |volume=73 |issue= 1 |pages= 41–9 |year= 1999 |pmid= 10386953 |doi=
*cite journal | author=Ultsch MH, Wiesmann C, Simmons LC, "et al." |title=Crystal structures of the neurotrophin-binding domain of TrkA, TrkB and TrkC. |journal=J. Mol. Biol. |volume=290 |issue= 1 |pages= 149–59 |year= 1999 |pmid= 10388563 |doi= 10.1006/jmbi.1999.2816

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

  • TrkB receptor — Neurotrophic tyrosine kinase, receptor, type 2 PDB rendering based on 1hcf …   Wikipedia

  • TrkC receptor — Neurotrophic tyrosine kinase, receptor, type 3 PDB rendering based on 1wwc …   Wikipedia

  • Metabotropic receptor — is a subtype of membrane receptors at the surface or in vesicles of eukaryotic cells. In the nervous system, based on their structural and functional characteristics, neurotransmitter receptors can be classified into two broad categories:… …   Wikipedia

  • Guanylate cyclase — (EC 4.6.1.2, also known as guanylyl cyclase, guanyl cyclase or GC) is a lyase enzyme. Contents 1 Reaction 2 Types 3 Function …   Wikipedia

  • Epidermal growth factor receptor — This article is about a cell surface receptor. For estimated measure of kidney function (eGFR), see Glomerular filtration rate. Epidermal growth factor receptor …   Wikipedia

  • MuSK protein — muscle, skeletal, receptor tyrosine kinase Identifiers Symbol MUSK Entrez …   Wikipedia

  • TrkB — protein Name = neurotrophic tyrosine kinase, receptor, type 2 caption = width = HGNCid = 8032 Symbol = NTRK2 AltSymbols = EntrezGene = 4915 OMIM = 600456 RefSeq = NM 001007097 UniProt = Q16620 PDB = ECnumber = 2.7.1.112 Chromosome = 9 Arm = q… …   Wikipedia

  • Platelet-derived growth factor receptor — platelet derived growth factor receptor, alpha polypeptide Identifiers Symbol PDGFRA Entrez 5156 HUGO …   Wikipedia

  • Fibroblast growth factor receptor 2 — PDB rendering based on 1djs …   Wikipedia

  • Angiopoietin receptor — tyrosine kinase with immunoglobulin like and EGF like domains 1 Identifiers Symbol TIE1 Alt. symbols TIE, JTK14 Entrez …   Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”