Angiopoietin 1

Angiopoietin 1

Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.

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section_title =
summary_text = Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. [cite web | title = Entrez Gene: ANGPT1 angiopoietin 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=284| accessdate = ]

ee also

* Angiopoietin

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Metheny-Barlow LJ, Li LY |title=The enigmatic role of angiopoietin-1 in tumor angiogenesis. |journal=Cell Res. |volume=13 |issue= 5 |pages= 309–17 |year= 2004 |pmid= 14672554 |doi= 10.1038/sj.cr.7290176
*cite journal | author=Makinde T, Murphy RF, Agrawal DK |title=Immunomodulatory role of vascular endothelial growth factor and angiopoietin-1 in airway remodeling. |journal=Curr. Mol. Med. |volume=6 |issue= 8 |pages= 831–41 |year= 2007 |pmid= 17168735 |doi=
*cite journal | author=Nomura N, Miyajima N, Sazuka T, "et al." |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1. |journal=DNA Res. |volume=1 |issue= 1 |pages= 27–35 |year= 1995 |pmid= 7584026 |doi=
*cite journal | author=Nomura N, Miyajima N, Sazuka T, "et al." |title=Prediction of the coding sequences of unidentified human genes. I. The coding sequences of 40 new genes (KIAA0001-KIAA0040) deduced by analysis of randomly sampled cDNA clones from human immature myeloid cell line KG-1 (supplement). |journal=DNA Res. |volume=1 |issue= 1 |pages= 47–56 |year= 1995 |pmid= 7584028 |doi=
*cite journal | author=Rüegg C, Pytela R |title=Sequence of a human transcript expressed in T-lymphocytes and encoding a fibrinogen-like protein. |journal=Gene |volume=160 |issue= 2 |pages= 257–62 |year= 1995 |pmid= 7642106 |doi=
*cite journal | author=Davis S, Aldrich TH, Jones PF, "et al." |title=Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning. |journal=Cell |volume=87 |issue= 7 |pages= 1161–9 |year= 1997 |pmid= 8980223 |doi=
*cite journal | author=Suri C, Jones PF, Patan S, "et al." |title=Requisite role of angiopoietin-1, a ligand for the TIE2 receptor, during embryonic angiogenesis. |journal=Cell |volume=87 |issue= 7 |pages= 1171–80 |year= 1997 |pmid= 8980224 |doi=
*cite journal | author=Maisonpierre PC, Suri C, Jones PF, "et al." |title=Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis. |journal=Science |volume=277 |issue= 5322 |pages= 55–60 |year= 1997 |pmid= 9204896 |doi=
*cite journal | author=Ristimäki A, Narko K, Enholm B, "et al." |title=Proinflammatory cytokines regulate expression of the lymphatic endothelial mitogen vascular endothelial growth factor-C. |journal=J. Biol. Chem. |volume=273 |issue= 14 |pages= 8413–8 |year= 1998 |pmid= 9525952 |doi=
*cite journal | author=Cheung AH, Stewart RJ, Marsden PA |title=Endothelial Tie2/Tek ligands angiopoietin-1 (ANGPT1) and angiopoietin-2 (ANGPT2): regional localization of the human genes to 8q22.3-q23 and 8p23. |journal=Genomics |volume=48 |issue= 3 |pages= 389–91 |year= 1998 |pmid= 9545648 |doi= 10.1006/geno.1997.5207
*cite journal | author=Witzenbichler B, Maisonpierre PC, Jones P, "et al." |title=Chemotactic properties of angiopoietin-1 and -2, ligands for the endothelial-specific receptor tyrosine kinase Tie2. |journal=J. Biol. Chem. |volume=273 |issue= 29 |pages= 18514–21 |year= 1998 |pmid= 9660821 |doi=
*cite journal | author=Sato A, Iwama A, Takakura N, "et al." |title=Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells. |journal=Int. Immunol. |volume=10 |issue= 8 |pages= 1217–27 |year= 1998 |pmid= 9723709 |doi=
*cite journal | author=Valenzuela DM, Griffiths JA, Rojas J, "et al." |title=Angiopoietins 3 and 4: diverging gene counterparts in mice and humans. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 5 |pages= 1904–9 |year= 1999 |pmid= 10051567 |doi=
*cite journal | author=Grosios K, Leek JP, Markham AF, "et al." |title=Assignment of ANGPT4, ANGPT1, and ANGPT2 encoding angiopoietins 4, 1 and 2 to human chromosome bands 20p13, 8q22.3-->q23 and 8p23.1, respectively, by in situ hybridization and radiation hybrid mapping. |journal=Cytogenet. Cell Genet. |volume=84 |issue= 1-2 |pages= 118–20 |year= 1999 |pmid= 10343124 |doi=
*cite journal | author=Procopio WN, Pelavin PI, Lee WM, Yeilding NM |title=Angiopoietin-1 and -2 coiled coil domains mediate distinct homo-oligomerization patterns, but fibrinogen-like domains mediate ligand activity. |journal=J. Biol. Chem. |volume=274 |issue= 42 |pages= 30196–201 |year= 1999 |pmid= 10514510 |doi=
*cite journal | author=Huang YQ, Li JJ, Karpatkin S |title=Identification of a family of alternatively spliced mRNA species of angiopoietin-1. |journal=Blood |volume=95 |issue= 6 |pages= 1993–9 |year= 2000 |pmid= 10706866 |doi=
*cite journal | author=Kim I, Kim JH, Ryu YS, "et al." |title=Characterization and expression of a novel alternatively spliced human angiopoietin-2. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18550–6 |year= 2000 |pmid= 10766762 |doi= 10.1074/jbc.M910084199
*cite journal | author=Dunk C, Shams M, Nijjar S, "et al." |title=Angiopoietin-1 and angiopoietin-2 activate trophoblast Tie-2 to promote growth and migration during placental development. |journal=Am. J. Pathol. |volume=156 |issue= 6 |pages= 2185–99 |year= 2000 |pmid= 10854239 |doi=
*cite journal | author=Krikun G, Schatz F, Finlay T, "et al." |title=Expression of angiopoietin-2 by human endometrial endothelial cells: regulation by hypoxia and inflammation. |journal=Biochem. Biophys. Res. Commun. |volume=275 |issue= 1 |pages= 159–63 |year= 2000 |pmid= 10944458 |doi= 10.1006/bbrc.2000.3277

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Look at other dictionaries:

  • Angiopoietin — protein Name = angiopoietin 1 caption = width = HGNCid = 484 Symbol = ANGPT1 AltSymbols = EntrezGene = 284 OMIM = 601667 RefSeq = NM 001146 UniProt = Q15389 PDB = ECnumber = Chromosome = 8 Arm = q Band = 22 LocusSupplementaryData = .3 8q23protein …   Wikipedia

  • angiopoietin — Angiopoetin 1 (498 residues) is the ligand for Tie2; angiopoietin 2 (496 residues) is a natural antagonist. Angiopoietin 1, but not Ang 2, is chemotactic for endothelial cells: neither have effects on proliferation …   Dictionary of molecular biology

  • Angiopoietin receptor — tyrosine kinase with immunoglobulin like and EGF like domains 1 Identifiers Symbol TIE1 Alt. symbols TIE, JTK14 Entrez …   Wikipedia

  • angiopoietin — noun A protein growth factor that promotes angiogenesis …   Wiktionary

  • ANGPT2 — Angiopoietin 2, also known as ANGPT2, is a human gene. PBB Summary section title = summary text = Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin 1 [cite web |… …   Wikipedia

  • ANGPTL1 — Angiopoietin like 1, also known as ANGPTL1, is a human gene.cite web | title = Entrez Gene: ANGPTL1 angiopoietin like 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=9068| accessdate = ] PBB Summary… …   Wikipedia

  • ANGPTL4 — Angiopoietin like 4, also known as ANGPTL4, is a human gene.cite web | title = Entrez Gene: ANGPTL4 angiopoietin like 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=51129| accessdate = ] PBB Summary… …   Wikipedia

  • ANGPTL3 — Angiopoietin like 3, also known as ANGPTL3, is a human gene.cite web | title = Entrez Gene: ANGPTL3 angiopoietin like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=27329| accessdate = ] PBB Summary… …   Wikipedia

  • ANGPT4 — Angiopoietin 4, also known as ANGPT4, is a human gene.cite web | title = Entrez Gene: ANGPT4 angiopoietin 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=51378| accessdate = ] PBB Summary section title =… …   Wikipedia

  • ANGPTL2 — Angiopoietin like 2, also known as ANGPTL2, is a human gene. PBB Summary section title = summary text = Angiopoietins are members of the vascular endothelial growth factor family and the only known growth factors largely specific for vascular… …   Wikipedia

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