ANGPTL3

Angiopoietin-like 3, also known as ANGPTL3, is a human gene.cite web | title = Entrez Gene: ANGPTL3 angiopoietin-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27329| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis.cite web | title = Entrez Gene: ANGPTL3 angiopoietin-like 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27329| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Li C |title=Genetics and regulation of angiopoietin-like proteins 3 and 4. |journal=Curr. Opin. Lipidol. |volume=17 |issue= 2 |pages= 152–6 |year= 2007 |pmid= 16531751 |doi= 10.1097/01.mol.0000217896.67444.05
*cite journal | author=Conklin D, Gilbertson D, Taft DW, "et al." |title=Identification of a mammalian angiopoietin-related protein expressed specifically in liver. |journal=Genomics |volume=62 |issue= 3 |pages= 477–82 |year= 2000 |pmid= 10644446 |doi= 10.1006/geno.1999.6041
*cite journal | author=Camenisch G, Pisabarro MT, Sherman D, "et al." |title=ANGPTL3 stimulates endothelial cell adhesion and migration via integrin alpha vbeta 3 and induces blood vessel formation in vivo. |journal=J. Biol. Chem. |volume=277 |issue= 19 |pages= 17281–90 |year= 2002 |pmid= 11877390 |doi= 10.1074/jbc.M109768200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kaplan R, Zhang T, Hernandez M, "et al." |title=Regulation of the angiopoietin-like protein 3 gene by LXR. |journal=J. Lipid Res. |volume=44 |issue= 1 |pages= 136–43 |year= 2003 |pmid= 12518032 |doi=
*cite journal | author=Shimamura M, Matsuda M, Kobayashi S, "et al." |title=Angiopoietin-like protein 3, a hepatic secretory factor, activates lipolysis in adipocytes. |journal=Biochem. Biophys. Res. Commun. |volume=301 |issue= 2 |pages= 604–9 |year= 2003 |pmid= 12565906 |doi=
*cite journal | author=Zeng L, Dai J, Ying K, "et al." |title=Identification of a novel human angiopoietin-like gene expressed mainly in heart. |journal=J. Hum. Genet. |volume=48 |issue= 3 |pages= 159–62 |year= 2003 |pmid= 12624729 |doi= 10.1007/s100380300025
*cite journal | author=Ono M, Shimizugawa T, Shimamura M, "et al." |title=Protein region important for regulation of lipid metabolism in angiopoietin-like 3 (ANGPTL3): ANGPTL3 is cleaved and activated in vivo. |journal=J. Biol. Chem. |volume=278 |issue= 43 |pages= 41804–9 |year= 2004 |pmid= 12909640 |doi= 10.1074/jbc.M302861200
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819–24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065
*cite journal | author=Shimamura M, Matsuda M, Yasumo H, "et al." |title=Angiopoietin-like protein3 regulates plasma HDL cholesterol through suppression of endothelial lipase. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=27 |issue= 2 |pages= 366–72 |year= 2007 |pmid= 17110602 |doi= 10.1161/01.ATV.0000252827.51626.89

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