Soluble fms-like tyrosine kinase-1
- Soluble fms-like tyrosine kinase-1
Soluble fms-like tyrosine kinase-1 (sFlt-1 or sVEGFR-1), a tyrosine kinase protein which disables proteins that cause blood vessel growth.
Splicing of the Flt-1 pre m-RNA can result in the full-length Flt-1 receptor , or in its shorter soluble form: sFlt-1. These proteins act as a receptor of vascular endothelial growth factor (VEGF), a potent angiogenic growth factor. (Another VEGF receptor is KDR).
Soluble Flt-1 binds and inhibits VEGF activity,- a VEGF antagonist. It is also an antagonist of placental growth factor, PlGF. Like soluble endoglin, it has been found to be implicated in the development of pre-eclampsia.
The activity of this enzyme is responsible for the non-vascular nature of the cornea of the eye of most mammals. In the manatee, which has a vascular cornea, this kinase is not active.
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