- GSK3B
Glycogen synthase kinase 3 beta, also known as GSK3B, is a human
gene .Glycogen synthase kinase-3 (
GSK-3 ) is a proline-directed serine-threonine kinase that was initially identified as a phosphorylating and inactivatingglycogen synthase . Two isoforms, alpha (GSK3A ) and beta, show a high degree of amino acid homology.cite journal | author = Stambolic V, Woodgett JR | title = Mitogen inactivation of glycogen synthase kinase-3 beta in intact cells via serine 9 phosphorylation | journal = Biochem. J. | volume = 303 ( Pt 3) | issue = | pages = 701–4 | year = 1994 | month = November | pmid = 7980435 | pmc = 1137602 | url = | issn = ] GSK3B is involved in energy metabolism, neuronal cell development, and body pattern formation.cite journal | author = Plyte SE, Hughes K, Nikolakaki E, Pulverer BJ, Woodgett JR | title = Glycogen synthase kinase-3: functions in oncogenesis and development | journal = Biochim. Biophys. Acta | volume = 1114 | issue = 2-3 | pages = 147–62 | year = 1992 | month = December | pmid = 1333807 | doi = 10.1016/0304-419X(92)90012-N | url = | issn = ] [cite web | title = Entrez Gene: GSK3B glycogen synthase kinase 3 beta| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2932| accessdate = ]ee also
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Glycogen synthase kinase 3 References
Further reading
*PBB_Further_reading
citations =
*cite journal | author=Plyte SE, Hughes K, Nikolakaki E, "et al." |title=Glycogen synthase kinase-3: functions in oncogenesis and development. |journal=Biochim. Biophys. Acta |volume=1114 |issue= 2-3 |pages= 147–62 |year= 1993 |pmid= 1333807 |doi=
*cite journal | author=Morishima-Kawashima M, Hasegawa M, Takio K, "et al." |title=Hyperphosphorylation of tau in PHF. |journal=Neurobiol. Aging |volume=16 |issue= 3 |pages= 365–71; discussion 371–80 |year= 1995 |pmid= 7566346 |doi=
*cite journal | author=Jope RS, Bijur GN |title=Mood stabilizers, glycogen synthase kinase-3beta and cell survival. |journal=Mol. Psychiatry |volume=7 Suppl 1 |issue= |pages= S35–45 |year= 2002 |pmid= 11986994 |doi= 10.1038/sj.mp.4001017
*cite journal | author=Bhat RV, Budd SL |title=GSK3beta signalling: casting a wide net in Alzheimer's disease. |journal=Neurosignals |volume=11 |issue= 5 |pages= 251–61 |year= 2003 |pmid= 12566926 |doi= 10.1159/000067423
*cite journal | author=Nadri C, Kozlovsky N, Agam G |title= [Schizophrenia, neurodevelopment and glycogen synthase kinase-3] |journal=Harefuah |volume=142 |issue= 8-9 |pages= 636–42, 644 |year= 2003 |pmid= 14518171 |doi=
*cite journal | author=Mulholland DJ, Dedhar S, Wu H, Nelson CC |title=PTEN and GSK3beta: key regulators of progression to androgen-independent prostate cancer. |journal=Oncogene |volume=25 |issue= 3 |pages= 329–37 |year= 2006 |pmid= 16421604 |doi= 10.1038/sj.onc.1209020PBB_Controls
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