p21 activated kinases

p21 activated kinases (PAKs) are members of a family of enzymes.^[1] They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological activities.

Members include:

• PAK1, regulating cell motility and morphology^[2]
• PAK2, possibly playing a role in apoptosis^[3]
• PAK3, possibly for dendritic development and for the rapid cytoskeletal reorganization in dendritic spines associated with synaptic plasticity^[4]
• PAK4, a mediator of filopodia formation^[5]

References

1. ^ MeSH p21-Activated+Kinases
2. ^ "Entrez Gene: PAK1 p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5058. 
3. ^ "Entrez Gene: PAK2 p21 (CDKN1A)-activated kinase 2". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5062. 
4. ^ "Entrez Gene: PAK3 p21 (CDKN1A)-activated kinase 3". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5063. 
5. ^ "Entrez Gene: PAK4 p21(CDKN1A)-activated kinase 4". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10298. 

External links

• PAK Info with links in the Cell Migration Gateway

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