ARHGEF7

Rho guanine nucleotide exchange factor (GEF) 7, also known as ARHGEF7, is a human gene.cite web | title = Entrez Gene: ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8874| accessdate = ]

PBB_Summary
section_title =
summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging bound GDP for GTP. It may form a complex with G proteins and stimulate Rho-dependent signals. This protein can induce membrane ruffling. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene, but some of their full-length sequences have not been determined.cite web | title = Entrez Gene: ARHGEF7 Rho guanine nucleotide exchange factor (GEF) 7| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8874| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Matoba R, Okubo K, Hori N, "et al." |title=The addition of 5'-coding information to a 3'-directed cDNA library improves analysis of gene expression. |journal=Gene |volume=146 |issue= 2 |pages= 199–207 |year= 1994 |pmid= 8076819 |doi=
*cite journal | author=Nagase T, Seki N, Tanaka A, "et al." |title=Prediction of the coding sequences of unidentified human genes. IV. The coding sequences of 40 new genes (KIAA0121-KIAA0160) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=2 |issue= 4 |pages= 167–74, 199–210 |year= 1996 |pmid= 8590280 |doi=
*cite journal | author=Oh WK, Yoo JC, Jo D, "et al." |title=Cloning of a SH3 domain-containing proline-rich protein, p85SPR, and its localization in focal adhesion. |journal=Biochem. Biophys. Res. Commun. |volume=235 |issue= 3 |pages= 794–8 |year= 1997 |pmid= 9207241 |doi= 10.1006/bbrc.1997.6875
*cite journal | author=Manser E, Loo TH, Koh CG, "et al." |title=PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. |journal=Mol. Cell |volume=1 |issue= 2 |pages= 183–92 |year= 1998 |pmid= 9659915 |doi=
*cite journal | author=Bagrodia S, Taylor SJ, Jordon KA, "et al." |title=A novel regulator of p21-activated kinases. |journal=J. Biol. Chem. |volume=273 |issue= 37 |pages= 23633–6 |year= 1998 |pmid= 9726964 |doi=
*cite journal | author=Turner CE, Brown MC, Perrotta JA, "et al." |title=Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling. |journal=J. Cell Biol. |volume=145 |issue= 4 |pages= 851–63 |year= 1999 |pmid= 10330411 |doi=
*cite journal | author=Bagrodia S, Bailey D, Lenard Z, "et al." |title=A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. |journal=J. Biol. Chem. |volume=274 |issue= 32 |pages= 22393–400 |year= 1999 |pmid= 10428811 |doi=
*cite journal | author=Premont RT, Claing A, Vitale N, "et al." |title=The GIT family of ADP-ribosylation factor GTPase-activating proteins. Functional diversity of GIT2 through alternative splicing. |journal=J. Biol. Chem. |volume=275 |issue= 29 |pages= 22373–80 |year= 2000 |pmid= 10896954 |doi=
*cite journal | author=Ku GM, Yablonski D, Manser E, "et al." |title=A PAK1-PIX-PKL complex is activated by the T-cell receptor independent of Nck, Slp-76 and LAT. |journal=EMBO J. |volume=20 |issue= 3 |pages= 457–65 |year= 2001 |pmid= 11157752 |doi= 10.1093/emboj/20.3.457
*cite journal | author=Koh CG, Tan EJ, Manser E, Lim L |title=The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. |journal=Curr. Biol. |volume=12 |issue= 4 |pages= 317–21 |year= 2002 |pmid= 11864573 |doi=
*cite journal | author=Brown MC, West KA, Turner CE |title=Paxillin-dependent paxillin kinase linker and p21-activated kinase localization to focal adhesions involves a multistep activation pathway. |journal=Mol. Biol. Cell |volume=13 |issue= 5 |pages= 1550–65 |year= 2002 |pmid= 12006652 |doi= 10.1091/mbc.02-02-0015
*cite journal | author=Shin EY, Shin KS, Lee CS, "et al." |title=Phosphorylation of p85 beta PIX, a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth factor-induced neurite outgrowth. |journal=J. Biol. Chem. |volume=277 |issue= 46 |pages= 44417–30 |year= 2003 |pmid= 12226077 |doi= 10.1074/jbc.M203754200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Rosenberger G, Jantke I, Gal A, Kutsche K |title=Interaction of alphaPIX (ARHGEF6) with beta-parvin (PARVB) suggests an involvement of alphaPIX in integrin-mediated signaling. |journal=Hum. Mol. Genet. |volume=12 |issue= 2 |pages= 155–67 |year= 2003 |pmid= 12499396 |doi=
*cite journal | author=Park E, Na M, Choi J, "et al." |title=The Shank family of postsynaptic density proteins interacts with and promotes synaptic accumulation of the beta PIX guanine nucleotide exchange factor for Rac1 and Cdc42. |journal=J. Biol. Chem. |volume=278 |issue= 21 |pages= 19220–9 |year= 2003 |pmid= 12626503 |doi= 10.1074/jbc.M301052200
*cite journal | author=Mignone F, Grillo G, Liuni S, Pesole G |title=Computational identification of protein coding potential of conserved sequence tags through cross-species evolutionary analysis. |journal=Nucleic Acids Res. |volume=31 |issue= 15 |pages= 4639–45 |year= 2003 |pmid= 12888525 |doi=
*cite journal | author=Yamamoto Y, Fujimoto Y, Arai R, "et al." |title=Retrotransposon-mediated restoration of Chlorella telomeres: accumulation of Zepp retrotransposons at termini of newly formed minichromosomes. |journal=Nucleic Acids Res. |volume=31 |issue= 15 |pages= 4646–53 |year= 2003 |pmid= 12888526 |doi=
*cite journal | author=Flanders JA, Feng Q, Bagrodia S, "et al." |title=The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins. |journal=FEBS Lett. |volume=550 |issue= 1-3 |pages= 119–23 |year= 2003 |pmid= 12935897 |doi=
*cite journal | author=Shin EY, Woo KN, Lee CS, "et al." |title=Basic fibroblast growth factor stimulates activation of Rac1 through a p85 betaPIX phosphorylation-dependent pathway. |journal=J. Biol. Chem. |volume=279 |issue= 3 |pages= 1994–2004 |year= 2004 |pmid= 14557270 |doi= 10.1074/jbc.M307330200
*cite journal | author=Lim CS, Kim SH, Jung JG, "et al." |title=Regulation of SPIN90 phosphorylation and interaction with Nck by ERK and cell adhesion. |journal=J. Biol. Chem. |volume=278 |issue= 52 |pages= 52116–23 |year= 2004 |pmid= 14559906 |doi= 10.1074/jbc.M310974200

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