CDC42

CDC42

CDC42 is a protein involved in regulation of the cell cycle.

PBB_Summary
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summary_text = The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. [cite web | title = Entrez Gene: CDC42 cell division cycle 42 (GTP binding protein, 25kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=998| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ramakers GJ |title=Rho proteins, mental retardation and the cellular basis of cognition. |journal=Trends Neurosci. |volume=25 |issue= 4 |pages= 191–9 |year= 2002 |pmid= 11998687 |doi=

External links

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  • CDC42EP2 — CDC42 effector protein (Rho GTPase binding) 2, also known as CDC42EP2, is a human gene.cite web | title = Entrez Gene: CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • CDC42EP3 — CDC42 effector protein (Rho GTPase binding) 3, also known as CDC42EP3, is a human gene.cite web | title = Entrez Gene: CDC42EP3 CDC42 effector protein (Rho GTPase binding) 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • CDC42EP1 — CDC42 effector protein (Rho GTPase binding) 1, also known as CDC42EP1, is a human gene.cite web | title = Entrez Gene: CDC42EP1 CDC42 effector protein (Rho GTPase binding) 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

  • CDC42EP4 — CDC42 effector protein (Rho GTPase binding) 4, also known as CDC42EP4, is a human gene.cite web | title = Entrez Gene: CDC42EP4 CDC42 effector protein (Rho GTPase binding) 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

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  • Rho family of GTPases — The Rho family of GTPases is a family of small ( 21 kDa) signaling G protein (more specific, a GTPase), and is a subfamily of the Ras superfamily. The members of the Rho GTPase family have been shown to regulate many aspects of intracellular… …   Wikipedia

  • TNK2 — Tyrosine kinase, non receptor, 2, also known as TNK2, is a human gene.cite web | title = Entrez Gene: TNK2 tyrosine kinase, non receptor, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10188| accessdate …   Wikipedia

  • PAK1 — P21 protein (Cdc42/Rac) activated kinase 1 PDB rendering based on 1e0a …   Wikipedia

  • PAK2 — P21 protein (Cdc42/Rac) activated kinase 2 PDB rendering based on 1e0a …   Wikipedia

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