CDC42

CDC42

CDC42 is a protein involved in regulation of the cell cycle.

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a small GTPase of the Rho-subfamily, which regulates signaling pathways that control diverse cellular functions including cell morphology, migration, endocytosis and cell cycle progression. This protein is highly similar to Saccharomyces cerevisiae Cdc 42, and is able to complement the yeast cdc42-1 mutant. The product of oncogene Dbl was reported to specifically catalyze the dissociation of GDP from this protein. This protein could regulate actin polymerization through its direct binding to Neural Wiskott-Aldrich syndrome protein (N-WASP), which subsequently activates Arp2/3 complex. Alternative splicing of this gene results in multiple transcript variants. [cite web | title = Entrez Gene: CDC42 cell division cycle 42 (GTP binding protein, 25kDa)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=998| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Ramakers GJ |title=Rho proteins, mental retardation and the cellular basis of cognition. |journal=Trends Neurosci. |volume=25 |issue= 4 |pages= 191–9 |year= 2002 |pmid= 11998687 |doi=

External links

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