CDC42EP2

CDC42 effector protein (Rho GTPase binding) 2, also known as CDC42EP2, is a human gene.cite web | title = Entrez Gene: CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10435| accessdate = ]

PBB_Summary
section_title =
summary_text = CDC42, a small Rho GTPase, regulates the formation of F-actin-containing structures through its interaction with the downstream effector proteins. The protein encoded by this gene is a member of the Borg family of CDC42 effector proteins. Borg family proteins contain a CRIB (Cdc42/Rac interactive-binding) domain. They bind to, and negatively regulate the function of, CDC42. Coexpression of this protein with dominant negative mutant CDC42 protein in fibroblast was found to induce pseudopodia formation, which suggested a role of this protein in actin filament assembly and cell shape control.cite web | title = Entrez Gene: CDC42EP2 CDC42 effector protein (Rho GTPase binding) 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10435| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Guru SC, Agarwal SK, Manickam P, "et al." |title=A transcript map for the 2.8-Mb region containing the multiple endocrine neoplasia type 1 locus. |journal=Genome Res. |volume=7 |issue= 7 |pages= 725–35 |year= 1997 |pmid= 9253601 |doi=
*cite journal | author=Burbelo PD, Snow DM, Bahou W, Spiegel S |title=MSE55, a Cdc42 effector protein, induces long cellular extensions in fibroblasts. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 16 |pages= 9083–8 |year= 1999 |pmid= 10430899 |doi=
*cite journal | author=Joberty G, Perlungher RR, Macara IG |title=The Borgs, a new family of Cdc42 and TC10 GTPase-interacting proteins. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6585–97 |year= 2000 |pmid= 10490598 |doi=
*cite journal | author=Hirsch DS, Pirone DM, Burbelo PD |title=A new family of Cdc42 effector proteins, CEPs, function in fibroblast and epithelial cell shape changes. |journal=J. Biol. Chem. |volume=276 |issue= 2 |pages= 875–83 |year= 2001 |pmid= 11035016 |doi= 10.1074/jbc.M007039200
*cite journal | author=Joberty G, Perlungher RR, Sheffield PJ, "et al." |title=Borg proteins control septin organization and are negatively regulated by Cdc42. |journal=Nat. Cell Biol. |volume=3 |issue= 10 |pages= 861–6 |year= 2001 |pmid= 11584266 |doi= 10.1038/ncb1001-861
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Xue Y, Bi F, Zhang X, "et al." |title=Role of Rac1 and Cdc42 in hypoxia induced p53 and von Hippel-Lindau suppression and HIF1alpha activation. |journal=Int. J. Cancer |volume=118 |issue= 12 |pages= 2965–72 |year= 2006 |pmid= 16395716 |doi= 10.1002/ijc.21763

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