CDC42BPA

CDC42BPA

CDC42 binding protein kinase alpha (DMPK-like), also known as CDC42BPA, is a human gene.cite web | title = Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8476| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the Serine/Threonine protein kinase family. This kinase contains multiple functional domains. Its kinase domain is highly similar to that of the myotonic dystrophy protein kinase (DMPK). This kinase also contains a Rac interactive binding (CRIB) domain, and has been shown to bind CDC42. It may function as a CDC42 downstream effector mediating CDC42 induced peripheral actin formation, and promoting cytoskeletal reorganization. Multiple alternatively spliced transcript variants have been described, and the full-length nature of two of them has been reported.cite web | title = Entrez Gene: CDC42BPA CDC42 binding protein kinase alpha (DMPK-like)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8476| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhao Y, Loyer P, Li H, "et al." |title=Cloning and chromosomal location of a novel member of the myotonic dystrophy family of protein kinases. |journal=J. Biol. Chem. |volume=272 |issue= 15 |pages= 10013–20 |year= 1997 |pmid= 9092543 |doi=
*cite journal | author=Leung T, Chen XQ, Tan I, "et al." |title=Myotonic dystrophy kinase-related Cdc42-binding kinase acts as a Cdc42 effector in promoting cytoskeletal reorganization. |journal=Mol. Cell. Biol. |volume=18 |issue= 1 |pages= 130–40 |year= 1998 |pmid= 9418861 |doi=
*cite journal | author=Seki N, Ohira M, Nagase T, "et al." |title=Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. |journal=DNA Res. |volume=4 |issue= 5 |pages= 345–9 |year= 1998 |pmid= 9455484 |doi=
*cite journal | author=Moncrieff CL, Bailey ME, Morrison N, Johnson KJ |title=Cloning and chromosomal localization of human Cdc42-binding protein kinase beta. |journal=Genomics |volume=57 |issue= 2 |pages= 297–300 |year= 1999 |pmid= 10198171 |doi= 10.1006/geno.1999.5769
*cite journal | author=Edwards DC, Sanders LC, Bokoch GM, Gill GN |title=Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. |journal=Nat. Cell Biol. |volume=1 |issue= 5 |pages= 253–9 |year= 1999 |pmid= 10559936 |doi= 10.1038/12963
*cite journal | author=Ohashi K, Nagata K, Maekawa M, "et al." |title=Rho-associated kinase ROCK activates LIM-kinase 1 by phosphorylation at threonine 508 within the activation loop. |journal=J. Biol. Chem. |volume=275 |issue= 5 |pages= 3577–82 |year= 2000 |pmid= 10652353 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Nakamura N, Oshiro N, Fukata Y, "et al." |title=Phosphorylation of ERM proteins at filopodia induced by Cdc42. |journal=Genes Cells |volume=5 |issue= 7 |pages= 571–81 |year= 2000 |pmid= 10947843 |doi=
*cite journal | author=Lam LT, Pham YC, Nguyen TM, Morris GE |title=Characterization of a monoclonal antibody panel shows that the myotonic dystrophy protein kinase, DMPK, is expressed almost exclusively in muscle and heart. |journal=Hum. Mol. Genet. |volume=9 |issue= 14 |pages= 2167–73 |year= 2000 |pmid= 10958655 |doi=
*cite journal | author=Tan I, Seow KT, Lim L, Leung T |title=Intermolecular and intramolecular interactions regulate catalytic activity of myotonic dystrophy kinase-related Cdc42-binding kinase alpha. |journal=Mol. Cell. Biol. |volume=21 |issue= 8 |pages= 2767–78 |year= 2001 |pmid= 11283256 |doi= 10.1128/MCB.21.8.2767-2778.2001
*cite journal | author=Sumi T, Matsumoto K, Shibuya A, Nakamura T |title=Activation of LIM kinases by myotonic dystrophy kinase-related Cdc42-binding kinase alpha. |journal=J. Biol. Chem. |volume=276 |issue= 25 |pages= 23092–6 |year= 2001 |pmid= 11340065 |doi= 10.1074/jbc.C100196200
*cite journal | author=Lemercier C, Brocard MP, Puvion-Dutilleul F, "et al." |title=Class II histone deacetylases are directly recruited by BCL6 transcriptional repressor. |journal=J. Biol. Chem. |volume=277 |issue= 24 |pages= 22045–52 |year= 2002 |pmid= 11929873 |doi= 10.1074/jbc.M201736200
*cite journal | author=Dong JM, Leung T, Manser E, Lim L |title=Cdc42 antagonizes inductive action of cAMP on cell shape, via effects of the myotonic dystrophy kinase-related Cdc42-binding kinase (MRCK) on myosin light chain phosphorylation. |journal=Eur. J. Cell Biol. |volume=81 |issue= 4 |pages= 231–42 |year= 2003 |pmid= 12018391 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Tan I, Cheong A, Lim L, Leung T |title=Genomic organization of human myotonic dystrophy kinase-related Cdc42-binding kinase alpha reveals multiple alternative splicing and functional diversity. |journal=Gene |volume=304 |issue= |pages= 107–15 |year= 2003 |pmid= 12568720 |doi=
*cite journal | author=Wilkinson S, Paterson HF, Marshall CJ |title=Cdc42-MRCK and Rho-ROCK signalling cooperate in myosin phosphorylation and cell invasion. |journal=Nat. Cell Biol. |volume=7 |issue= 3 |pages= 255–61 |year= 2005 |pmid= 15723050 |doi= 10.1038/ncb1230
*cite journal | author=Cmejla R, Petrak J, Cmejlova J |title=A novel iron responsive element in the 3'UTR of human MRCKalpha. |journal=Biochem. Biophys. Res. Commun. |volume=341 |issue= 1 |pages= 158–66 |year= 2006 |pmid= 16412980 |doi= 10.1016/j.bbrc.2005.12.155
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Lefort K, Mandinova A, Ostano P, "et al." |title=Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases. |journal=Genes Dev. |volume=21 |issue= 5 |pages= 562–77 |year= 2007 |pmid= 17344417 |doi= 10.1101/gad.1484707

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