- IRAK2
Interleukin-1 receptor-associated kinase 2, also known as IRAK2, is a human
gene .cite web | title = Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3656| accessdate = ]PBB_Summary
section_title =
summary_text = IRAK2 encodes the interleukin-1 receptor-associated kinase 2, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. IRAK2 is reported to participate in the IL1-induced upregulation of NF-kappaB.cite web | title = Entrez Gene: IRAK2 interleukin-1 receptor-associated kinase 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3656| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Auron PE |title=The interleukin 1 receptor: ligand interactions and signal transduction. |journal=Cytokine Growth Factor Rev. |volume=9 |issue= 3-4 |pages= 221–37 |year= 1999 |pmid= 9918122 |doi=
*cite journal | author=Muzio M, Ni J, Feng P, Dixit VM |title=IRAK (Pelle) family member IRAK-2 and MyD88 as proximal mediators of IL-1 signaling. |journal=Science |volume=278 |issue= 5343 |pages= 1612–5 |year= 1997 |pmid= 9374458 |doi=
*cite journal | author=Maschera B, Ray K, Burns K, Volpe F |title=Overexpression of an enzymically inactive interleukin-1-receptor-associated kinase activates nuclear factor-kappaB. |journal=Biochem. J. |volume=339 ( Pt 2) |issue= |pages= 227–31 |year= 1999 |pmid= 10191251 |doi=
*cite journal | author=Wesche H, Gao X, Li X, "et al." |title=IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. |journal=J. Biol. Chem. |volume=274 |issue= 27 |pages= 19403–10 |year= 1999 |pmid= 10383454 |doi=
*cite journal | author=Fitzgerald KA, Palsson-McDermott EM, Bowie AG, "et al." |title=Mal (MyD88-adapter-like) is required for Toll-like receptor-4 signal transduction. |journal=Nature |volume=413 |issue= 6851 |pages= 78–83 |year= 2001 |pmid= 11544529 |doi= 10.1038/35092578
*cite journal | author=McDermott EP, O'Neill LA |title=Ras participates in the activation of p38 MAPK by interleukin-1 by associating with IRAK, IRAK2, TRAF6, and TAK-1. |journal=J. Biol. Chem. |volume=277 |issue= 10 |pages= 7808–15 |year= 2002 |pmid= 11744690 |doi= 10.1074/jbc.M108133200
*cite journal | author=Shin BK, Wang H, Yim AM, "et al." |title=Global profiling of the cell surface proteome of cancer cells uncovers an abundance of proteins with chaperone function. |journal=J. Biol. Chem. |volume=278 |issue= 9 |pages= 7607–16 |year= 2003 |pmid= 12493773 |doi= 10.1074/jbc.M210455200
*cite journal | author=Bin LH, Xu LG, Shu HB |title=TIRP, a novel Toll/interleukin-1 receptor (TIR) domain-containing adapter protein involved in TIR signaling. |journal=J. Biol. Chem. |volume=278 |issue= 27 |pages= 24526–32 |year= 2003 |pmid= 12721283 |doi= 10.1074/jbc.M303451200
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Kuzmin I, Geil L, Gibson L, "et al." |title=Transcriptional regulator CTCF controls human interleukin 1 receptor-associated kinase 2 promoter. |journal=J. Mol. Biol. |volume=346 |issue= 2 |pages= 411–22 |year= 2005 |pmid= 15670593 |doi= 10.1016/j.jmb.2004.11.066
*cite journal | author=Keating SE, Maloney GM, Moran EM, Bowie AG |title=IRAK-2 participates in multiple toll-like receptor signaling pathways to NFkappaB via activation of TRAF6 ubiquitination. |journal=J. Biol. Chem. |volume=282 |issue= 46 |pages= 33435–43 |year= 2008 |pmid= 17878161 |doi= 10.1074/jbc.M705266200PBB_Controls
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