GNB3

Guanine nucleotide binding protein (G protein), beta polypeptide 3, also known as GNB3, is a human gene.

PBB_Summary
section_title =
summary_text = Heterotrimeric guanine nucleotide-binding proteins (G proteins), which integrate signals between receptors and effector proteins, are composed of an alpha, a beta, and a gamma subunit. These subunits are encoded by families of related genes. This gene encodes a beta subunit. Beta subunits are important regulators of alpha subunits, as well as of certain signal transduction receptors and effectors. A single-nucleotide polymorphism (C825T) in this gene is associated with essential hypertension and obesity. This polymorphism is also associated with the occurrence of the splice variant GNB3-s, which appears to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Additional splice variants may exist for this gene, but they have not been fully described. [cite web | title = Entrez Gene: GNB3 guanine nucleotide binding protein (G protein), beta polypeptide 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2784| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Wedegaertner PB, Wilson PT, Bourne HR |title=Lipid modifications of trimeric G proteins. |journal=J. Biol. Chem. |volume=270 |issue= 2 |pages= 503–6 |year= 1995 |pmid= 7822269 |doi=
*cite journal | author=Downes GB, Gautam N |title=The G protein subunit gene families. |journal=Genomics |volume=62 |issue= 3 |pages= 544–52 |year= 2000 |pmid= 10644457 |doi= 10.1006/geno.1999.5992
*cite journal | author=Sartori M, Parotto E, Ceolotto G, "et al." |title= [C825T polymorphism of the GNB3 gene codifying the G-protein beta3-subunit and cardiovascular risk] |journal=Ann. Ital. Med. Int. |volume=19 |issue= 4 |pages= 240–8 |year= 2005 |pmid= 15678704 |doi=
*cite journal | author=Zhu H, Wang X, Lu Y, "et al." |title=Update on G-protein polymorphisms in hypertension. |journal=Curr. Hypertens. Rep. |volume=8 |issue= 1 |pages= 23–9 |year= 2006 |pmid= 16600156 |doi=
*cite journal | author=Weder AB |title=Genetics and hypertension. |journal=Journal of clinical hypertension (Greenwich, Conn.) |volume=9 |issue= 3 |pages= 217–23 |year= 2007 |pmid= 17341998 |doi=
*cite journal | author=Levine MA, Modi WS, O'Brien SJ |title=Chromosomal localization of the genes encoding two forms of the G protein beta polypeptide, beta 1 and beta 3, in man. |journal=Genomics |volume=8 |issue= 2 |pages= 380–6 |year= 1991 |pmid= 1979057 |doi=
*cite journal | author=Levine MA, Smallwood PM, Moen PT, "et al." |title=Molecular cloning of beta 3 subunit, a third form of the G protein beta-subunit polypeptide. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 6 |pages= 2329–33 |year= 1990 |pmid= 2107550 |doi=
*cite journal | author=Garcia-Higuera I, Thomas TC, Yi F, Neer EJ |title=Intersubunit surfaces in G protein alpha beta gamma heterotrimers. Analysis by cross-linking and mutagenesis of beta gamma. |journal=J. Biol. Chem. |volume=271 |issue= 1 |pages= 528–35 |year= 1996 |pmid= 8550614 |doi=
*cite journal | author=Yan K, Kalyanaraman V, Gautam N |title=Differential ability to form the G protein betagamma complex among members of the beta and gamma subunit families. |journal=J. Biol. Chem. |volume=271 |issue= 12 |pages= 7141–6 |year= 1996 |pmid= 8636150 |doi=
*cite journal | author=Ansari-Lari MA, Muzny DM, Lu J, "et al." |title=A gene-rich cluster between the CD4 and triosephosphate isomerase genes at human chromosome 12p13. |journal=Genome Res. |volume=6 |issue= 4 |pages= 314–26 |year= 1996 |pmid= 8723724 |doi=
*cite journal | author=Ansari-Lari MA, Shen Y, Muzny DM, "et al." |title=Large-scale sequencing in human chromosome 12p13: experimental and computational gene structure determination. |journal=Genome Res. |volume=7 |issue= 3 |pages= 268–80 |year= 1997 |pmid= 9074930 |doi=
*cite journal | author=Siffert W, Rosskopf D, Siffert G, "et al." |title=Association of a human G-protein beta3 subunit variant with hypertension. |journal=Nat. Genet. |volume=18 |issue= 1 |pages= 45–8 |year= 1998 |pmid= 9425898 |doi= 10.1038/ng0198-45
*cite journal | author=Kageyama K, Murakami T, Iizuka K, "et al." |title=Translocation of G-protein beta3 subunit from the cytosol pool to the membrane pool by beta1-adrenergic receptor stimulation in perfused rat hearts. |journal=Biochem. Pharmacol. |volume=58 |issue= 9 |pages= 1497–500 |year= 1999 |pmid= 10513993 |doi=
*cite journal | author=Rosskopf D, Busch S, Manthey I, Siffert W |title=G protein beta 3 gene: structure, promoter, and additional polymorphisms. |journal=Hypertension |volume=36 |issue= 1 |pages= 33–41 |year= 2000 |pmid= 10904009 |doi=
*cite journal | author=Obineche EN, Frossard PM, Bokhari AM |title=An association study of five genetic loci and left ventricular hypertrophy amongst Gulf Arabs. |journal=Hypertens. Res. |volume=24 |issue= 6 |pages= 635–9 |year= 2002 |pmid= 11768721 |doi=
*cite journal | author=Tabara Y, Kohara K, Miki T |title=Polymorphisms of genes encoding components of the sympathetic nervous system but not the renin-angiotensin system as risk factors for orthostatic hypotension. |journal=J. Hypertens. |volume=20 |issue= 4 |pages= 651–6 |year= 2002 |pmid= 11910300 |doi=
*cite journal | author=Serretti A, Lorenzi C, Lilli R, "et al." |title=Pharmacogenetics of lithium prophylaxis in mood disorders: analysis of COMT, MAO-A, and Gbeta3 variants. |journal=Am. J. Med. Genet. |volume=114 |issue= 4 |pages= 370–9 |year= 2002 |pmid= 11992559 |doi= 10.1002/ajmg.10357
*cite journal | author=Shlyakhto EV, Shwartz EI, Nefedova YB, "et al." |title=Lack of association of G-protein subunit gene C825T polymorphism with left ventricular hypertrophy in essential hypertension. |journal=Med. Sci. Monit. |volume=8 |issue= 5 |pages= CR337–40 |year= 2002 |pmid= 12011775 |doi=

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