CDKN3

Cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase), also known as CDKN3, is a human gene.cite web | title = Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1033| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to the dual specificity protein phosphatase family. It was identified as a cyclin-dependent kinase inhibitor, and has been shown to interact with, and dephosphorylate CDK2 kinase, thus prevent the activation of CDK2 kinase. This gene was reported to be deleted, mutated, or overexpressed in several kinds of cancers.cite web | title = Entrez Gene: CDKN3 cyclin-dependent kinase inhibitor 3 (CDK2-associated dual specificity phosphatase)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1033| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Poon RY, Hunter T |title=Dephosphorylation of Cdk2 Thr160 by the cyclin-dependent kinase-interacting phosphatase KAP in the absence of cyclin. |journal=Science |volume=270 |issue= 5233 |pages= 90–3 |year= 1995 |pmid= 7569954 |doi=
*cite journal | author=Demetrick DJ, Matsumoto S, Hannon GJ, "et al." |title=Chromosomal mapping of the genes for the human cell cycle proteins cyclin C (CCNC), cyclin E (CCNE), p21 (CDKN1) and KAP (CDKN3). |journal=Cytogenet. Cell Genet. |volume=69 |issue= 3-4 |pages= 190–2 |year= 1995 |pmid= 7698009 |doi=
*cite journal | author=Hannon GJ, Casso D, Beach D |title=K

*cite journal | author=Gyuris J, Golemis E, Chertkov H, Brent R |title=Cdi1, a human G1 and S phase protein phosphatase that associates with Cdk2. |journal=Cell |volume=75 |issue= 4 |pages= 791–803 |year= 1993 |pmid= 8242750 |doi=
*cite journal | author=Harper JW, Adami GR, Wei N, "et al." |title=The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases. |journal=Cell |volume=75 |issue= 4 |pages= 805–16 |year= 1993 |pmid= 8242751 |doi=
*cite journal | author=Sexl V, Diehl JA, Sherr CJ, "et al." |title=A rate limiting function of cdc25A for S phase entry inversely correlates with tyrosine dephosphorylation of Cdk2. |journal=Oncogene |volume=18 |issue= 3 |pages= 573–82 |year= 1999 |pmid= 9989807 |doi= 10.1038/sj.onc.1202362
*cite journal | author=Lee SW, Reimer CL, Fang L, "et al." |title=Overexpression of kinase-associated phosphatase (KAP) in breast and prostate cancer and inhibition of the transformed phenotype by antisense KAP expression. |journal=Mol. Cell. Biol. |volume=20 |issue= 5 |pages= 1723–32 |year= 2000 |pmid= 10669749 |doi=
*cite journal | author=Yeh CT, Lu SC, Chen TC, "et al." |title=Aberrant transcripts of the cyclin-dependent kinase-associated protein phosphatase in hepatocellular carcinoma. |journal=Cancer Res. |volume=60 |issue= 17 |pages= 4697–700 |year= 2000 |pmid= 10987270 |doi=
*cite journal | author=Song H, Hanlon N, Brown NR, "et al." |title=Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. |journal=Mol. Cell |volume=7 |issue= 3 |pages= 615–26 |year= 2001 |pmid= 11463386 |doi=
*cite journal | author=Wang H, Iakova P, Wilde M, "et al." |title=C/EBPalpha arrests cell proliferation through direct inhibition of Cdk2 and Cdk4. |journal=Mol. Cell |volume=8 |issue= 4 |pages= 817–28 |year= 2001 |pmid= 11684017 |doi=
*cite journal | author=Donato JL, Ko J, Kutok JL, "et al." |title=Human HTm4 is a hematopoietic cell cycle regulator. |journal=J. Clin. Invest. |volume=109 |issue= 1 |pages= 51–8 |year= 2002 |pmid= 11781350 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Yeh CT, Lu SC, Chao CH, Chao ML |title=Abolishment of the interaction between cyclin-dependent kinase 2 and Cdk-associated protein phosphatase by a truncated KAP mutant. |journal=Biochem. Biophys. Res. Commun. |volume=305 |issue= 2 |pages= 311–4 |year= 2003 |pmid= 12745075 |doi=
*cite journal | author=Niculescu MD, Yamamuro Y, Zeisel SH |title=Choline availability modulates human neuroblastoma cell proliferation and alters the methylation of the promoter region of the cyclin-dependent kinase inhibitor 3 gene. |journal=J. Neurochem. |volume=89 |issue= 5 |pages= 1252–9 |year= 2004 |pmid= 15147518 |doi= 10.1111/j.1471-4159.2004.02414.x
*cite journal | author=Chinami M, Yano Y, Yang X, "et al." |title=Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2. |journal=J. Biol. Chem. |volume=280 |issue= 17 |pages= 17235–42 |year= 2005 |pmid= 15671017 |doi= 10.1074/jbc.M413437200
*cite journal | author=Hsieh MJ, Yao YL, Lai IL, Yang WM |title=Transcriptional repression activity of PAX3 is modulated by competition between corepressor KAP1 and heterochromatin protein 1. |journal=Biochem. Biophys. Res. Commun. |volume=349 |issue= 2 |pages= 573–81 |year= 2006 |pmid= 16945326 |doi= 10.1016/j.bbrc.2006.08.064
*cite journal | author=Okamoto K, Kitabayashi I, Taya Y |title=KAP1 dictates p53 response induced by chemotherapeutic agents via Mdm2 interaction. |journal=Biochem. Biophys. Res. Commun. |volume=351 |issue= 1 |pages= 216–22 |year= 2006 |pmid= 17056014 |doi= 10.1016/j.bbrc.2006.10.022

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