CCNC (gene)

CCNC (gene)
Cyclin C
Symbols CCNC;
External IDs OMIM123838 MGI1858199 HomoloGene3803 GeneCards: CCNC Gene
RNA expression pattern
PBB GE CCNC 201955 at tn.png
More reference expression data
Species Human Mouse
Entrez 892 51813
Ensembl ENSG00000112237 ENSMUSG00000028252
UniProt P24863 Q0P542
RefSeq (mRNA) NM_001013399.1 NM_016746
RefSeq (protein) NP_001013417.1 NP_058026
Location (UCSC) Chr 6:
99.99 – 100.02 Mb
Chr 4:
21.65 – 21.69 Mb
PubMed search [1] [2]

Cyclin-C is a protein that in humans is encoded by the CCNC gene.[1][2]

The protein encoded by this gene is a member of the cyclin family of proteins. The encoded protein interacts with cyclin-dependent kinase 8 and induces the phophorylation of the carboxy-terminal domain of the large subunit of RNA polymerase II. The level of mRNAs for this gene peaks in the G1 phase of the cell cycle. Two transcript variants encoding different isoforms have been found for this gene.[2]


CCNC (gene) has been shown to interact with Estrogen receptor alpha[3] and Cyclin-dependent kinase 8.[4][5][6][3][7]


  1. ^ Lew DJ, Dulic V, Reed SI (Oct 1991). "Isolation of three novel human cyclins by rescue of G1 cyclin (Cln) function in yeast". Cell 66 (6): 1197–206. doi:10.1016/0092-8674(91)90042-W. PMID 1833066. 
  2. ^ a b "Entrez Gene: CCNC cyclin C". 
  3. ^ a b Kang, Yun Kyoung; Guermah Mohamed, Yuan Chao-Xing, Roeder Robert G (Mar. 2002). "The TRAP/Mediator coactivator complex interacts directly with estrogen receptors α and β through the TRAP220 subunit and directly enhances estrogen receptor function in vitro". Proc. Natl. Acad. Sci. U.S.A. (United States) 99 (5): 2642–7. doi:10.1073/pnas.261715899. ISSN 0027-8424. PMC 122401. PMID 11867769. 
  4. ^ Zhang, Y; Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D (May. 1997). "Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex". Cell (UNITED STATES) 89 (3): 357–64. doi:10.1016/S0092-8674(00)80216-0. ISSN 0092-8674. PMID 9150135. 
  5. ^ Cho, H; Orphanides G, Sun X, Yang X J, Ogryzko V, Lees E, Nakatani Y, Reinberg D (Sep. 1998). "A Human RNA Polymerase II Complex Containing Factors That Modify Chromatin Structure". Mol. Cell. Biol. (UNITED STATES) 18 (9): 5355–63. ISSN 0270-7306. PMC 109120. PMID 9710619. 
  6. ^ Wang, G; Cantin G T, Stevens J L, Berk A J (Jul. 2001). "Characterization of Mediator Complexes from HeLa Cell Nuclear Extract". Mol. Cell. Biol. (United States) 21 (14): 4604–13. doi:10.1128/MCB.21.14.4604-4613.2001. ISSN 0270-7306. PMC 87123. PMID 11416138. 
  7. ^ Tassan, J P; Jaquenoud M, Léopold P, Schultz S J, Nigg E A (Sep. 1995). "Identification of human cyclin-dependent kinase 8, a putative protein kinase partner for cyclin C". Proc. Natl. Acad. Sci. U.S.A. (UNITED STATES) 92 (19): 8871–5. doi:10.1073/pnas.92.19.8871. ISSN 0027-8424. PMC 41069. PMID 7568034. 

Further reading

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