DUSP19

Dual specificity phosphatase 19
Identifiers
Symbols	DUSP19; DUSP17; LMWDSP3; MGC138210; SKRP1; TS-DSP1
External IDs	OMIM: 611437 MGI: 1915332 HomoloGene: 41565 GeneCards: DUSP19 Gene
Gene Ontology Molecular function • protein tyrosine phosphatase activity • protein kinase inhibitor activity • MAP-kinase scaffold activity • protein tyrosine/threonine phosphatase activity • JUN kinase phosphatase activity • hydrolase activity • protein kinase activator activity • mitogen-activated protein kinase kinase kinase binding Cellular component • cytoplasm Biological process • inactivation of MAPK activity • positive regulation of protein phosphorylation • negative regulation of protein kinase activity • protein dephosphorylation • JNK cascade • positive regulation of MAPKKK cascade • positive regulation of JUN kinase activity • negative regulation of JUN kinase activity • positive regulation of protein kinase activity • negative regulation of JNK cascade • positive regulation of JNK cascade Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	142679	68082
Ensembl	ENSG00000162999	ENSMUSG00000027001
UniProt	Q8WTR2	Q99N12
RefSeq (mRNA)	NM_001142314.1	NM_024438.4
RefSeq (protein)	NP_001135786.1	NP_077758.1
Location (UCSC)	Chr 2: 183.94 – 183.96 Mb	Chr 2: 80.46 – 80.47 Mb
PubMed search	[1]	[2]

Dual specificity protein phosphatase 19 is an enzyme that in humans is encoded by the DUSP19 gene.^[1]

Interactions

DUSP19 has been shown to interact with ASK1^[2] and MAP2K7.^[2][3]

References

1. ^ "Entrez Gene: DUSP19 dual specificity phosphatase 19". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=142679. 
2. ^ ^{a b} Zama, Takeru; Aoki Ryoko, Kamimoto Takahiro, Inoue Koichi, Ikeda Yasuo, Hagiwara Masatoshi (Jun. 2002). "Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway". J. Biol. Chem. (United States) 277 (26): 23919–26. doi:10.1074/jbc.M200838200. ISSN 0021-9258. PMID 11959862. 
3. ^ Zama, Takeru; Aoki Ryoko, Kamimoto Takahiro, Inoue Koichi, Ikeda Yasuo, Hagiwara Masatoshi (Jun. 2002). "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway". J. Biol. Chem. (United States) 277 (26): 23909–18. doi:10.1074/jbc.M200837200. ISSN 0021-9258. PMID 11959861. 

Further reading

• Hillier LW, Graves TA, Fulton RS et al. (2005). "Generation and annotation of the DNA sequences of human chromosomes 2 and 4". Nature 434 (7034): 724–31. doi:10.1038/nature03466. PMID 15815621. 
• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Ota T, Suzuki Y, Nishikawa T et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039. 
• Cheng H, Gao Q, Jiang M et al. (2003). "Molecular cloning and characterization of a novel human protein phosphatase, LMW-DSP3". Int. J. Biochem. Cell Biol. 35 (2): 226–34. doi:10.1016/S1357-2725(02)00127-9. PMID 12479873. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Zama T, Aoki R, Kamimoto T et al. (2002). "Scaffold role of a mitogen-activated protein kinase phosphatase, SKRP1, for the JNK signaling pathway". J. Biol. Chem. 277 (26): 23919–26. doi:10.1074/jbc.M200838200. PMID 11959862. 
• Zama T, Aoki R, Kamimoto T et al. (2002). "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway". J. Biol. Chem. 277 (26): 23909–18. doi:10.1074/jbc.M200837200. PMID 11959861.