DEFB129

Defensin, beta 129
Identifiers
Symbols	DEFB129; C20orf87; DEFB-29; DEFB29; bA530N10.3; hBD-29
External IDs	MGI: 3644405 HomoloGene: 83411 GeneCards: DEFB129 Gene
Gene Ontology Cellular component • extracellular region Biological process • defense response to bacterium Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	140881	629114
Ensembl	ENSG00000125903	ENSMUSG00000074681
UniProt	Q9H1M3	Q30KP0
RefSeq (mRNA)	NM_080831.3	NM_001037933.2
RefSeq (protein)	NP_543021.1	NP_001033022.1
Location (UCSC)	Chr 20: 0.21 – 0.21 Mb	Chr 2: 152.28 – 152.29 Mb
PubMed search	[1]	[2]

Beta-defensin 129 is a protein that in humans is encoded by the DEFB129 gene.^[1][2]

Defensins are cysteine-rich cationic polypeptides that are important in the immunologic response to invading microorganisms. The protein encoded by this gene is secreted and is a member of the beta defensin protein family. Beta defensin genes are found in several clusters throughout the genome, with this gene mapping to a cluster at 20p13.^[2]

References

1. ^ Schutte BC, Mitros JP, Bartlett JA, Walters JD, Jia HP, Welsh MJ, Casavant TL, McCray PB Jr (Feb 2002). "Discovery of five conserved β-defensin gene clusters using a computational search strategy". Proc Natl Acad Sci U S A 99 (4): 2129–33. doi:10.1073/pnas.042692699. PMC 122330. PMID 11854508. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=122330. 
2. ^ ^{a b} "Entrez Gene: DEFB129 defensin, beta 129". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=140881. 

Further reading

• Gerhard DS, Wagner L, Feingold EA et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Clark HF, Gurney AL, Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697. 
• Rodríguez-Jiménez FJ, Krause A, Schulz S et al. (2003). "Distribution of new human beta-defensin genes clustered on chromosome 20 in functionally different segments of epididymis". Genomics 81 (2): 175–83. doi:10.1016/S0888-7543(02)00034-4. PMID 12620395. 
• Kao CY, Chen Y, Zhao YH, Wu R (2003). "ORFeome-based search of airway epithelial cell-specific novel human [beta]-defensin genes". Am. J. Respir. Cell Mol. Biol. 29 (1): 71–80. doi:10.1165/rcmb.2002-0205OC. PMID 12600824. 
• Strausberg RL, Feingold EA, Grouse LH et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Deloukas P, Matthews LH, Ashurst J et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature 414 (6866): 865–71. doi:10.1038/414865a. PMID 11780052.