PTPRA

Protein tyrosine phosphatase, receptor type, A, also known as PTPRA, is a human gene.cite web | title = Entrez Gene: PTPRA protein tyrosine phosphatase, receptor type, A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5786| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. This PTP has been shown to dephosphorylate and activate Src family tyrosine kinases, and is implicated in the regulation of integrin signaling, cell adhesion and proliferation. Three alternatively spliced variants of this gene, which encode two distinct isoforms, have been reported.cite web | title = Entrez Gene: PTPRA protein tyrosine phosphatase, receptor type, A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5786| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Mustelin T, Hunter T |title=Meeting at mitosis: cell cycle-specific regulation of c-Src by RPTPalpha. |journal=Sci. STKE |volume=2002 |issue= 115 |pages= PE3 |year= 2002 |pmid= 11796915 |doi= 10.1126/stke.2002.115.pe3
*cite journal | author=Zheng XM, Wang Y, Pallen CJ |title=Cell transformation and activation of pp60c-src by overexpression of a protein tyrosine phosphatase. |journal=Nature |volume=359 |issue= 6393 |pages= 336–9 |year= 1992 |pmid= 1383828 |doi= 10.1038/359336a0
*cite journal | author=Jirik FR, Anderson LL, Duncan AM |title=The human protein-tyrosine phosphatase PTP alpha/LRP gene (PTPA) is assigned to chromosome 20p13. |journal=Cytogenet. Cell Genet. |volume=60 |issue= 2 |pages= 117–8 |year= 1992 |pmid= 1611910 |doi=
*cite journal | author=Rao VV, Löffler C, Sap J, "et al." |title=The gene for receptor-linked protein-tyrosine-phosphatase (PTPA) is assigned to human chromosome 20p12-pter by in situ hybridization (ISH and FISH). |journal=Genomics |volume=13 |issue= 3 |pages= 906–7 |year= 1992 |pmid= 1639427 |doi=
*cite journal | author=Sap J, D'Eustachio P, Givol D, Schlessinger J |title=Cloning and expression of a widely expressed receptor tyrosine phosphatase. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 16 |pages= 6112–6 |year= 1990 |pmid= 2166945 |doi=
*cite journal | author=Kaplan R, Morse B, Huebner K, "et al." |title=Cloning of three human tyrosine phosphatases reveals a multigene family of receptor-linked protein-tyrosine-phosphatases expressed in brain. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 18 |pages= 7000–4 |year= 1990 |pmid= 2169617 |doi=
*cite journal | author=Krueger NX, Streuli M, Saito H |title=Structural diversity and evolution of human receptor-like protein tyrosine phosphatases. |journal=EMBO J. |volume=9 |issue= 10 |pages= 3241–52 |year= 1990 |pmid= 2170109 |doi=
*cite journal | author=Jirik FR, Janzen NM, Melhado IG, Harder KW |title=Cloning and chromosomal assignment of a widely expressed human receptor-like protein-tyrosine phosphatase. |journal=FEBS Lett. |volume=273 |issue= 1-2 |pages= 239–42 |year= 1990 |pmid= 2172030 |doi=
*cite journal | author=Ohagi S, Nishi M, Steiner DF |title=Sequence of a cDNA encoding human LRP (leukocyte common antigen-related peptide). |journal=Nucleic Acids Res. |volume=18 |issue= 23 |pages= 7159 |year= 1991 |pmid= 2175890 |doi=
*cite journal | author=den Hertog J, Tracy S, Hunter T |title=Phosphorylation of receptor protein-tyrosine phosphatase alpha on Tyr789, a binding site for the SH3-SH2-SH3 adaptor protein GRB-2 in vivo. |journal=EMBO J. |volume=13 |issue= 13 |pages= 3020–32 |year= 1994 |pmid= 7518772 |doi=
*cite journal | author=den Hertog J, Pals CE, Peppelenbosch MP, "et al." |title=Receptor protein tyrosine phosphatase alpha activates pp60c-src and is involved in neuronal differentiation. |journal=EMBO J. |volume=12 |issue= 10 |pages= 3789–98 |year= 1993 |pmid= 7691597 |doi=
*cite journal | author=Stover DR, Furet P, Lydon NB |title=Modulation of the SH2 binding specificity and kinase activity of Src by tyrosine phosphorylation within its SH2 domain. |journal=J. Biol. Chem. |volume=271 |issue= 21 |pages= 12481–7 |year= 1996 |pmid= 8647855 |doi=
*cite journal | author=den Hertog J, Hunter T |title=Tight association of GRB2 with receptor protein-tyrosine phosphatase alpha is mediated by the SH2 and C-terminal SH3 domains. |journal=EMBO J. |volume=15 |issue= 12 |pages= 3016–27 |year= 1996 |pmid= 8670803 |doi=
*cite journal | author=Shimizu Y, Sugiyama H, Fujii Y, "et al." |title=Lineage- and differentiation stage-specific expression of LSM-1 (LPAP), a possible substrate for CD45, in human hematopoietic cells. |journal=Am. J. Hematol. |volume=54 |issue= 1 |pages= 1–11 |year= 1997 |pmid= 8980254 |doi=
*cite journal | author=Lim KL, Lai DS, Kalousek MB, "et al." |title=Kinetic analysis of two closely related receptor-like protein-tyrosine-phosphatases, PTP alpha and PTP epsilon. |journal=Eur. J. Biochem. |volume=245 |issue= 3 |pages= 693–700 |year= 1997 |pmid= 9183007 |doi=
*cite journal | author=Somani AK, Bignon JS, Mills GB, "et al." |title=Src kinase activity is regulated by the SHP-1 protein-tyrosine phosphatase. |journal=J. Biol. Chem. |volume=272 |issue= 34 |pages= 21113–9 |year= 1997 |pmid= 9261115 |doi=
*cite journal | author=Feito MJ, Bragardo M, Buonfiglio D, "et al." |title=gp 120s derived from four syncytium-inducing HIV-1 strains induce different patterns of CD4 association with lymphocyte surface molecules. |journal=Int. Immunol. |volume=9 |issue= 8 |pages= 1141–7 |year= 1997 |pmid= 9263011 |doi=
*cite journal | author=Norris K, Norris F, Kono DH, "et al." |title=Expression of protein-tyrosine phosphatases in the major insulin target tissues. |journal=FEBS Lett. |volume=415 |issue= 3 |pages= 243–8 |year= 1997 |pmid= 9357975 |doi=
*cite journal | author=Bhandari V, Lim KL, Pallen CJ |title=Physical and functional interactions between receptor-like protein-tyrosine phosphatase alpha and p59fyn. |journal=J. Biol. Chem. |volume=273 |issue= 15 |pages= 8691–8 |year= 1998 |pmid= 9535845 |doi=
*cite journal | author=Harder KW, Moller NP, Peacock JW, Jirik FR |title=Protein-tyrosine phosphatase alpha regulates Src family kinases and alters cell-substratum adhesion. |journal=J. Biol. Chem. |volume=273 |issue= 48 |pages= 31890–900 |year= 1998 |pmid= 9822658 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes