PTP4A2

Protein tyrosine phosphatase type IVA, member 2, also known as PTP4A2, is a human gene.cite web | title = Entrez Gene: PTP4A2 protein tyrosine phosphatase type IVA, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8073| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene belongs to a small class of the protein tyrosine phosphatase (PTP) family. PTPs are cell signaling molecules that play regulatory roles in a variety of cellular processes. PTPs in this class contain a protein tyrosine phosphatase catalytic domain and a characteristic C-terminal prenylation motif. This PTP has been shown to primarily associate with plasmic and endosomal membrane through its C-terminal prenylation. This PTP was found to interact with the beta-subunit of Rab geranylgeranyltransferase II (beta GGT II), and thus may function as a regulator of GGT II activity. Overexpression of this gene in mammalian cells conferred a transformed phenotype, which suggested its role in tumorigenesis. Alternatively spliced transcript variants that encode two distinct isoforms have been described.cite web | title = Entrez Gene: PTP4A2 protein tyrosine phosphatase type IVA, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8073| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rommens JM, Durocher F, McArthur J, "et al." |title=Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21. |journal=Genomics |volume=28 |issue= 3 |pages= 530–42 |year= 1996 |pmid= 7490091 |doi=
*cite journal | author=Montagna M, Serova O, Sylla BS, "et al." |title=A 100-kb physical and transcriptional map around the EDH17B2 gene: identification of three novel genes and a pseudogene of a human homologue of the rat PRL-1 tyrosine phosphatase. |journal=Hum. Genet. |volume=96 |issue= 5 |pages= 532–8 |year= 1996 |pmid= 8529999 |doi=
*cite journal | author=Zhao Z, Lee CC, Monckton DG, "et al." |title=Characterization and genomic mapping of genes and pseudogenes of a new human protein tyrosine phosphatase. |journal=Genomics |volume=35 |issue= 1 |pages= 172–81 |year= 1996 |pmid= 8661118 |doi= 10.1006/geno.1996.0336
*cite journal | author=Cates CA, Michael RL, Stayrook KR, "et al." |title=Prenylation of oncogenic human PTP(CAAX) protein tyrosine phosphatases. |journal=Cancer Lett. |volume=110 |issue= 1-2 |pages= 49–55 |year= 1997 |pmid= 9018080 |doi=
*cite journal | author=Zeng Q, Hong W, Tan YH |title=Mouse PRL-2 and PRL-3, two potentially prenylated protein tyrosine phosphatases homologous to PRL-1. |journal=Biochem. Biophys. Res. Commun. |volume=244 |issue= 2 |pages= 421–7 |year= 1998 |pmid= 9514946 |doi= 10.1006/bbrc.1998.8291
*cite journal | author=Gjörloff-Wingren A, Saxena M, Han S, "et al." |title=Subcellular localization of intracellular protein tyrosine phosphatases in T cells. |journal=Eur. J. Immunol. |volume=30 |issue= 8 |pages= 2412–21 |year= 2000 |pmid= 10940933 |doi=
*cite journal | author=Hartley JL, Temple GF, Brasch MA |title=DNA cloning using in vitro site-specific recombination. |journal=Genome Res. |volume=10 |issue= 11 |pages= 1788–95 |year= 2001 |pmid= 11076863 |doi=
*cite journal | author=Si X, Zeng Q, Ng CH, "et al." |title=Interaction of farnesylated PRL-2, a protein-tyrosine phosphatase, with the beta-subunit of geranylgeranyltransferase II. |journal=J. Biol. Chem. |volume=276 |issue= 35 |pages= 32875–82 |year= 2001 |pmid= 11447212 |doi= 10.1074/jbc.M010400200
*cite journal | author=Wang Q, Holmes DI, Powell SM, "et al." |title=Analysis of stromal-epithelial interactions in prostate cancer identifies PTPCAAX2 as a potential oncogene. |journal=Cancer Lett. |volume=175 |issue= 1 |pages= 63–9 |year= 2002 |pmid= 11734337 |doi=
*cite journal | author=Wang J, Kirby CE, Herbst R |title=The tyrosine phosphatase PRL-1 localizes to the endoplasmic reticulum and the mitotic spindle and is required for normal mitosis. |journal=J. Biol. Chem. |volume=277 |issue= 48 |pages= 46659–68 |year= 2003 |pmid= 12235145 |doi= 10.1074/jbc.M206407200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Pathak MK, Dhawan D, Lindner DJ, "et al." |title=Pentamidine is an inhibitor of PRL phosphatases with anticancer activity. |journal=Mol. Cancer Ther. |volume=1 |issue= 14 |pages= 1255–64 |year= 2003 |pmid= 12516958 |doi=
*cite journal | author=Werner SR, Lee PA, DeCamp MW, "et al." |title=Enhanced cell cycle progression and down regulation of p21(Cip1/Waf1) by PRL tyrosine phosphatases. |journal=Cancer Lett. |volume=202 |issue= 2 |pages= 201–11 |year= 2004 |pmid= 14643450 |doi=
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Wiemann S, Arlt D, Huber W, "et al." |title=From ORFeome to biology: a functional genomics pipeline. |journal=Genome Res. |volume=14 |issue= 10B |pages= 2136–44 |year= 2004 |pmid= 15489336 |doi= 10.1101/gr.2576704
*cite journal | author=Mehrle A, Rosenfelder H, Schupp I, "et al." |title=The LIFEdb database in 2006. |journal=Nucleic Acids Res. |volume=34 |issue= Database issue |pages= D415–8 |year= 2006 |pmid= 16381901 |doi= 10.1093/nar/gkj139
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Radke I, Götte M, Kersting C, "et al." |title=Expression and prognostic impact of the protein tyrosine phosphatases PRL-1, PRL-2, and PRL-3 in breast cancer. |journal=Br. J. Cancer |volume=95 |issue= 3 |pages= 347–54 |year= 2006 |pmid= 16832410 |doi= 10.1038/sj.bjc.6603261
*cite journal | author=Dumaual CM, Sandusky GE, Crowell PL, Randall SK |title=Cellular localization of PRL-1 and PRL-2 gene expression in normal adult human tissues. |journal=J. Histochem. Cytochem. |volume=54 |issue= 12 |pages= 1401–12 |year= 2007 |pmid= 16957164 |doi= 10.1369/jhc.6A7019.2006
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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