PTPRS

Protein tyrosine phosphatase, receptor type, S, also known as PTPRS, is a human gene.cite web | title = Entrez Gene: PTPRS protein tyrosine phosphatase, receptor type, S| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5802| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular region, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus represents a receptor-type PTP. The extracellular region of this protein is composed of multiple Ig-like and fibronectin type III-like domains. Studies of the similar gene in mice suggested that this PTP may be involved in cell-cell interaction, primary axonogenesis, and axon guidance during embryogenesis. This PTP has been also implicated in the molecular control of adult nerve repair. Four alternatively spliced transcript variants, which encode distinct proteins, have been reported.cite web | title = Entrez Gene: PTPRS protein tyrosine phosphatase, receptor type, S| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5802| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Adachi M, Sekiya M, Arimura Y, "et al." |title=Protein-tyrosine phosphatase expression in pre-B cell NALM-6. |journal=Cancer Res. |volume=52 |issue= 3 |pages= 737–40 |year= 1992 |pmid= 1370651 |doi=
*cite journal | author=Pulido R, Serra-Pagès C, Tang M, Streuli M |title=The LAR/PTP delta/PTP sigma subfamily of transmembrane protein-tyrosine-phosphatases: multiple human LAR, PTP delta, and PTP sigma isoforms are expressed in a tissue-specific manner and associate with the LAR-interacting protein LIP.1. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 25 |pages= 11686–90 |year= 1996 |pmid= 8524829 |doi=
*cite journal | author=Wagner J, Gordon LA, Heng HH, "et al." |title=Physical mapping of receptor type protein tyrosine phosphatase sigma (PTPRS) to human chromosome 19p13.3. |journal=Genomics |volume=38 |issue= 1 |pages= 76–8 |year= 1997 |pmid= 8954782 |doi= 10.1006/geno.1996.0594
*cite journal | author=Endo N, Rutledge SJ, Opas EE, "et al." |title=Human protein tyrosine phosphatase-sigma: alternative splicing and inhibition by bisphosphonates. |journal=J. Bone Miner. Res. |volume=11 |issue= 4 |pages= 535–43 |year= 1997 |pmid= 8992885 |doi=
*cite journal | author=Norris K, Norris F, Kono DH, "et al." |title=Expression of protein-tyrosine phosphatases in the major insulin target tissues. |journal=FEBS Lett. |volume=415 |issue= 3 |pages= 243–8 |year= 1997 |pmid= 9357975 |doi=
*cite journal | author=Wallace MJ, Fladd C, Batt J, Rotin D |title=The second catalytic domain of protein tyrosine phosphatase delta (PTP delta) binds to and inhibits the first catalytic domain of PTP sigma. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2608–16 |year= 1998 |pmid= 9566880 |doi=
*cite journal | author=Serra-Pagès C, Medley QG, Tang M, "et al." |title=Liprins, a family of LAR transmembrane protein-tyrosine phosphatase-interacting proteins. |journal=J. Biol. Chem. |volume=273 |issue= 25 |pages= 15611–20 |year= 1998 |pmid= 9624153 |doi=
*cite journal | author=Haworth K, Shu KK, Stokes A, "et al." |title=The expression of receptor tyrosine phosphatases is responsive to sciatic nerve crush. |journal=Mol. Cell. Neurosci. |volume=12 |issue= 3 |pages= 93–104 |year= 1998 |pmid= 9790732 |doi= 10.1006/mcne.1998.0707
*cite journal | author=Elchebly M, Wagner J, Kennedy TE, "et al." |title=Neuroendocrine dysplasia in mice lacking protein tyrosine phosphatase sigma. |journal=Nat. Genet. |volume=21 |issue= 3 |pages= 330–3 |year= 1999 |pmid= 10080191 |doi= 10.1038/6859
*cite journal | author=Wallace MJ, Batt J, Fladd CA, "et al." |title=Neuronal defects and posterior pituitary hypoplasia in mice lacking the receptor tyrosine phosphatase PTPsigma. |journal=Nat. Genet. |volume=21 |issue= 3 |pages= 334–8 |year= 1999 |pmid= 10080192 |doi= 10.1038/6866
*cite journal | author=Suárez Pestana E, Tenev T, Gross S, "et al." |title=The transmembrane protein tyrosine phosphatase RPTPsigma modulates signaling of the epidermal growth factor receptor in A431 cells. |journal=Oncogene |volume=18 |issue= 28 |pages= 4069–79 |year= 1999 |pmid= 10435588 |doi= 10.1038/sj.onc.1202794
*cite journal | author=Blanchetot C, Tertoolen LG, Overvoorde J, den Hertog J |title=Intra- and intermolecular interactions between intracellular domains of receptor protein-tyrosine phosphatases. |journal=J. Biol. Chem. |volume=277 |issue= 49 |pages= 47263–9 |year= 2003 |pmid= 12376545 |doi= 10.1074/jbc.M205810200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Hu YF, Zhang HL, Cai T, "et al." |title=The IA-2 interactome. |journal=Diabetologia |volume=48 |issue= 12 |pages= 2576–81 |year= 2006 |pmid= 16273344 |doi= 10.1007/s00125-005-0037-y
*cite journal | author=Liu T, Qian WJ, Gritsenko MA, "et al." |title=Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry. |journal=J. Proteome Res. |volume=4 |issue= 6 |pages= 2070–80 |year= 2006 |pmid= 16335952 |doi= 10.1021/pr0502065
*cite journal | author=Lajus S, Lang J |title=Splice variant 3, but not 2 of receptor protein-tyrosine phosphatase sigma can mediate stimulation of insulin-secretion by alpha-latrotoxin. |journal=J. Cell. Biochem. |volume=98 |issue= 6 |pages= 1552–9 |year= 2006 |pmid= 16552719 |doi= 10.1002/jcb.20871
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

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