[cite web | title = Entrez Gene: BCL2L2 BCL2-like 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=599| accessdate = ] ]Relative to its Bcl-2 counterparts there is considerably less data on this particular protein however much effort is being made to further understand its cellular roles. Located on chromosome 14q11 it appears to be redundant in most tissues apart from specific examples. It was originally discovered by Gibson "et al".[cite journal | author=Gibson L, Holmgreen SP, Huang DC, "et al." |title=bcl-w, a novel member of the bcl-2 family, promotes cell survival. |journal=Oncogene |volume=13 |issue= 4 |pages= 665–75 |year= 1996 |pmid= 8761287 |doi= ] ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Nagase T, Seki N, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain. |journal=DNA Res. |volume=3 |issue= 5 |pages= 321–9, 341–54 |year= 1997 |pmid= 9039502 |doi=
*cite journal | author=O'Connor L, Strasser A, O'Reilly LA, "et al." |title=Bim: a novel member of the Bcl-2 family that promotes apoptosis. |journal=EMBO J. |volume=17 |issue= 2 |pages= 384–95 |year= 1998 |pmid= 9430630 |doi= 10.1093/emboj/17.2.384
*cite journal | author=Ross AJ, Waymire KG, Moss JE, "et al." |title=Testicular degeneration in Bclw-deficient mice. |journal=Nat. Genet. |volume=18 |issue= 3 |pages= 251–6 |year= 1998 |pmid= 9500547 |doi= 10.1038/ng0398-251
*cite journal | author=Hsu SY, Lin P, Hsueh AJ |title=BOD (Bcl-2-related ovarian death gene) is an ovarian BH3 domain-containing proapoptotic Bcl-2 protein capable of dimerization with diverse antiapoptotic Bcl-2 members. |journal=Mol. Endocrinol. |volume=12 |issue= 9 |pages= 1432–40 |year= 1998 |pmid= 9731710 |doi=
*cite journal | author=Middleton G, Wyatt S, Ninkina N, Davies AM |title=Reciprocal developmental changes in the roles of Bcl-w and Bcl-x(L) in regulating sensory neuron survival. |journal=Development |volume=128 |issue= 3 |pages= 447–57 |year= 2001 |pmid= 11152643 |doi=
*cite journal | author=O'Reilly LA, Print C, Hausmann G, "et al." |title=Tissue expression and subcellular localization of the pro-survival molecule Bcl-w. |journal=Cell Death Differ. |volume=8 |issue= 5 |pages= 486–94 |year= 2001 |pmid= 11423909 |doi= 10.1038/sj/cdd/4400835
*cite journal | author=Bae J, Hsu SY, Leo CP, "et al." |title=Underphosphorylated BAD interacts with diverse antiapoptotic Bcl-2 family proteins to regulate apoptosis. |journal=Apoptosis |volume=6 |issue= 5 |pages= 319–30 |year= 2001 |pmid= 11483855 |doi=
*cite journal | author=Puthalakath H, Villunger A, O'Reilly LA, "et al." |title=Bmf: a proapoptotic BH3-only protein regulated by interaction with the myosin V actin motor complex, activated by anoikis. |journal=Science |volume=293 |issue= 5536 |pages= 1829–32 |year= 2001 |pmid= 11546872 |doi= 10.1126/science.1062257
*cite journal | author=Ayllón V, Cayla X, García A, "et al." |title=The anti-apoptotic molecules Bcl-xL and Bcl-w target protein phosphatase 1alpha to Bad. |journal=Eur. J. Immunol. |volume=32 |issue= 7 |pages= 1847–55 |year= 2002 |pmid= 12115603 |doi= 10.1002/1521-4141(200207)32:7<1847::AID-IMMU1847>3.0.CO;2-7 |doilabel=10.1002/1521-4141(200207)32:71847::AID-IMMU18473.0.CO;2-7
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Denisov AY, Madiraju MS, Chen G, "et al." |title=Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix. |journal=J. Biol. Chem. |volume=278 |issue= 23 |pages= 21124–8 |year= 2003 |pmid= 12651847 |doi= 10.1074/jbc.M301798200
*cite journal | author=Hinds MG, Lackmann M, Skea GL, "et al." |title=The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity. |journal=EMBO J. |volume=22 |issue= 7 |pages= 1497–507 |year= 2003 |pmid= 12660157 |doi= 10.1093/emboj/cdg144
*cite journal | author=Wilson-Annan J, O'Reilly LA, Crawford SA, "et al." |title=Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity. |journal=J. Cell Biol. |volume=162 |issue= 5 |pages= 877–87 |year= 2003 |pmid= 12952938 |doi= 10.1083/jcb.200302144
*cite journal | author=Zhu X, Wang Y, Ogawa O, "et al." |title=Neuroprotective properties of Bcl-w in Alzheimer disease. |journal=J. Neurochem. |volume=89 |issue= 5 |pages= 1233–40 |year= 2004 |pmid= 15147516 |doi= 10.1111/j.1471-4159.2004.02416.x
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Chen L, Willis SN, Wei A, "et al." |title=Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. |journal=Mol. Cell |volume=17 |issue= 3 |pages= 393–403 |year= 2005 |pmid= 15694340 |doi= 10.1016/j.molcel.2004.12.030
*cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, "et al." |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55–65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406
*cite journal | author=Denisov AY, Chen G, Sprules T, "et al." |title=Structural model of the BCL-w-BID peptide complex and its interactions with phospholipid micelles. |journal=Biochemistry |volume=45 |issue= 7 |pages= 2250–6 |year= 2006 |pmid= 16475813 |doi= 10.1021/bi052332s
*cite journal | author=Certo M, Del Gaizo Moore V, Nishino M, "et al." |title=Mitochondria primed by death signals determine cellular addiction to antiapoptotic BCL-2 family members. |journal=Cancer Cell |volume=9 |issue= 5 |pages= 351–65 |year= 2006 |pmid= 16697956 |doi= 10.1016/j.ccr.2006.03.027
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