CDC25B

Cell division cycle 25 homolog B (S. pombe), also known as CDC25B, is a human gene.

PBB_Summary
section_title =
summary_text = CDC25B is a member of the CDC25 family of phosphatases. CDC25B activates the cyclin dependent kinase CDC2 by removing two phosphate groups and it is required for entry into mitosis. CDC25B shuttles between the nucleus and the cytoplasm due to nuclear localization and nuclear export signals. The protein is nuclear in the M and G1 phases of the cell cycle and moves to the cytoplasm during S and G2. CDC25B has oncogenic properties, although its role in tumor formation has not been determined. Multiple transcript variants for this gene exist.cite web | title = Entrez Gene: CDC25B cell division cycle 25 homolog B (S. pombe)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=994| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Draetta G, Eckstein J |title=Cdc25 protein phosphatases in cell proliferation. |journal=Biochim. Biophys. Acta |volume=1332 |issue= 2 |pages= M53–63 |year= 1997 |pmid= 9141461 |doi=
*cite journal | author=Nilsson I, Hoffmann I |title=Cell cycle regulation by the Cdc25 phosphatase family. |journal=Progress in cell cycle research |volume=4 |issue= |pages= 107–14 |year= 2000 |pmid= 10740819 |doi=
*cite journal | author=Nagata A, Igarashi M, Jinno S, "et al." |title=An additional homolog of the fission yeast cdc25+ gene occurs in humans and is highly expressed in some cancer cells. |journal=New Biol. |volume=3 |issue= 10 |pages= 959–68 |year= 1992 |pmid= 1662986 |doi=
*cite journal | author=Galaktionov K, Beach D |title=Specific activation of cdc25 tyrosine phosphatases by B-type cyclins: evidence for multiple roles of mitotic cyclins. |journal=Cell |volume=67 |issue= 6 |pages= 1181–94 |year= 1992 |pmid= 1836978 |doi=
*cite journal | author=Conklin DS, Galaktionov K, Beach D |title=14-3-3 proteins associate with cdc25 phosphatases. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 17 |pages= 7892–6 |year= 1995 |pmid= 7644510 |doi=
*cite journal | author=Galaktionov K, Lee AK, Eckstein J, "et al." |title=CDC25 phosphatases as potential human oncogenes. |journal=Science |volume=269 |issue= 5230 |pages= 1575–7 |year= 1995 |pmid= 7667636 |doi=
*cite journal | author=Demetrick DJ, Beach DH |title=Chromosome mapping of human CDC25A and CDC25B phosphatases. |journal=Genomics |volume=18 |issue= 1 |pages= 144–7 |year= 1994 |pmid= 8276402 |doi= 10.1006/geno.1993.1440
*cite journal | author=Honda R, Ohba Y, Nagata A, "et al." |title=Dephosphorylation of human p34cdc2 kinase on both Thr-14 and Tyr-15 by human cdc25B phosphatase. |journal=FEBS Lett. |volume=318 |issue= 3 |pages= 331–4 |year= 1993 |pmid= 8440392 |doi=
*cite journal | author=Lane SA, Baker E, Sutherland GR, "et al." |title=The human cell cycle gene CDC25B is located at 20p13. |journal=Genomics |volume=15 |issue= 3 |pages= 693–4 |year= 1993 |pmid= 8468065 |doi= 10.1006/geno.1993.1129
*cite journal | author=Baldin V, Cans C, Superti-Furga G, Ducommun B |title=Alternative splicing of the human CDC25B tyrosine phosphatase. Possible implications for growth control? |journal=Oncogene |volume=14 |issue= 20 |pages= 2485–95 |year= 1997 |pmid= 9188863 |doi= 10.1038/sj.onc.1201063
*cite journal | author=Booher RN, Holman PS, Fattaey A |title=Human Myt1 is a cell cycle-regulated kinase that inhibits Cdc2 but not Cdk2 activity. |journal=J. Biol. Chem. |volume=272 |issue= 35 |pages= 22300–6 |year= 1997 |pmid= 9268380 |doi=
*cite journal | author=Sanchez Y, Wong C, Thoma RS, "et al." |title=Conservation of the Chk1 checkpoint pathway in mammals: linkage of DNA damage to Cdk regulation through Cdc25. |journal=Science |volume=277 |issue= 5331 |pages= 1497–501 |year= 1997 |pmid= 9278511 |doi=
*cite journal | author=Jin P, Hardy S, Morgan DO |title=Nuclear localization of cyclin B1 controls mitotic entry after DNA damage. |journal=J. Cell Biol. |volume=141 |issue= 4 |pages= 875–85 |year= 1998 |pmid= 9585407 |doi=
*cite journal | author=Hofmann K, Bucher P, Kajava AV |title=A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain. |journal=J. Mol. Biol. |volume=282 |issue= 1 |pages= 195–208 |year= 1998 |pmid= 9733650 |doi= 10.1006/jmbi.1998.1998
*cite journal | author=Forrest AR, McCormack AK, DeSouza CP, "et al." |title=Multiple splicing variants of cdc25B regulate G2/M progression. |journal=Biochem. Biophys. Res. Commun. |volume=260 |issue= 2 |pages= 510–5 |year= 1999 |pmid= 10403798 |doi= 10.1006/bbrc.1999.0870
*cite journal | author=Karlsson C, Katich S, Hagting A, "et al." |title=Cdc25B and Cdc25C differ markedly in their properties as initiators of mitosis. |journal=J. Cell Biol. |volume=146 |issue= 3 |pages= 573–84 |year= 1999 |pmid= 10444066 |doi=
*cite journal | author=Reynolds RA, Yem AW, Wolfe CL, "et al." |title=Crystal structure of the catalytic subunit of Cdc25B required for G2/M phase transition of the cell cycle. |journal=J. Mol. Biol. |volume=293 |issue= 3 |pages= 559–68 |year= 1999 |pmid= 10543950 |doi= 10.1006/jmbi.1999.3168
*cite journal | author=Mils V, Baldin V, Goubin F, "et al." |title=Specific interaction between 14-3-3 isoforms and the human CDC25B phosphatase. |journal=Oncogene |volume=19 |issue= 10 |pages= 1257–65 |year= 2000 |pmid= 10713667 |doi= 10.1038/sj.onc.1203419

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