UBR5

E3 ubiquitin protein ligase, HECT domain containing, 1, also known as EDD1, is a human gene.cite web | title = Entrez Gene: EDD1 E3 ubiquitin protein ligase, HECT domain containing, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51366| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a progestin-induced protein, which belongs to the HECT (homology to E6-AP carboxyl terminus) family. The HECT family proteins function as E3 ubiquitin-protein ligases, targeting specific proteins for ubiquitin-mediated proteolysis. This gene is localized to chromosome 8q22 which is disrupted in a variety of cancers. This gene potentially has a role in regulation of cell proliferation or differentiation.cite web | title = Entrez Gene: EDD1 E3 ubiquitin protein ligase, HECT domain containing, 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51366| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99–106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Callaghan MJ, Russell AJ, Woollatt E, "et al." |title=Identification of a human HECT family protein with homology to the Drosophila tumor suppressor gene hyperplastic discs. |journal=Oncogene |volume=17 |issue= 26 |pages= 3479–91 |year= 1999 |pmid= 10030672 |doi= 10.1038/sj.onc.1202249
*cite journal | author=Nagase T, Ishikawa K, Suyama M, "et al." |title=Prediction of the coding sequences of unidentified human genes. XII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 6 |pages= 355–64 |year= 1999 |pmid= 10048485 |doi=
*cite journal | author=Deo RC, Sonenberg N, Burley SK |title=X-ray structure of the human hyperplastic discs protein: an ortholog of the C-terminal domain of poly(A)-binding protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 8 |pages= 4414–9 |year= 2001 |pmid= 11287654 |doi= 10.1073/pnas.071552198
*cite journal | author=Honda Y, Tojo M, Matsuzaki K, "et al." |title=Cooperation of HECT-domain ubiquitin ligase hHYD and DNA topoisomerase II-binding protein for DNA damage response. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3599–605 |year= 2002 |pmid= 11714696 |doi= 10.1074/jbc.M104347200
*cite journal | author=Henderson MJ, Russell AJ, Hird S, "et al." |title=EDD, the human hyperplastic discs protein, has a role in progesterone receptor coactivation and potential involvement in DNA damage response. |journal=J. Biol. Chem. |volume=277 |issue= 29 |pages= 26468–78 |year= 2002 |pmid= 12011095 |doi= 10.1074/jbc.M203527200
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Eblen ST, Kumar NV, Shah K, "et al." |title=Identification of novel ERK2 substrates through use of an engineered kinase and ATP analogs. |journal=J. Biol. Chem. |volume=278 |issue= 17 |pages= 14926–35 |year= 2003 |pmid= 12594221 |doi= 10.1074/jbc.M300485200
*cite journal | author=Zhang C, Dowd DR, Staal A, "et al." |title=Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35325–36 |year= 2003 |pmid= 12840015 |doi= 10.1074/jbc.M305191200
*cite journal | author=Clancy JL, Henderson MJ, Russell AJ, "et al." |title=EDD, the human orthologue of the hyperplastic discs tumour suppressor gene, is amplified and overexpressed in cancer. |journal=Oncogene |volume=22 |issue= 32 |pages= 5070–81 |year= 2003 |pmid= 12902990 |doi= 10.1038/sj.onc.1206775
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Rush J, Moritz A, Lee KA, "et al." |title=Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. |journal=Nat. Biotechnol. |volume=23 |issue= 1 |pages= 94–101 |year= 2005 |pmid= 15592455 |doi= 10.1038/nbt1046
*cite journal | author=Tasaki T, Mulder LC, Iwamatsu A, "et al." |title=A family of mammalian E3 ubiquitin ligases that contain the UBR box motif and recognize N-degrons. |journal=Mol. Cell. Biol. |volume=25 |issue= 16 |pages= 7120–36 |year= 2005 |pmid= 16055722 |doi= 10.1128/MCB.25.16.7120-7136.2005
*cite journal | author=Kim JE, Tannenbaum SR, White FM |title=Global phosphoproteome of HT-29 human colon adenocarcinoma cells. |journal=J. Proteome Res. |volume=4 |issue= 4 |pages= 1339–46 |year= 2005 |pmid= 16083285 |doi= 10.1021/pr050048h
*cite journal | author=Nousiainen M, Silljé HH, Sauer G, "et al." |title=Phosphoproteome analysis of the human mitotic spindle. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 14 |pages= 5391–6 |year= 2006 |pmid= 16565220 |doi= 10.1073/pnas.0507066103
*cite journal | author=Henderson MJ, Munoz MA, Saunders DN, "et al." |title=EDD mediates DNA damage-induced activation of CHK2. |journal=J. Biol. Chem. |volume=281 |issue= 52 |pages= 39990–40000 |year= 2007 |pmid= 17074762 |doi= 10.1074/jbc.M602818200
*cite journal | author=Olsen JV, Blagoev B, Gnad F, "et al." |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635–48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026
*cite journal | author=Ewing RM, Chu P, Elisma F, "et al." |title=Large-scale mapping of human protein-protein interactions by mass spectrometry. |journal=Mol. Syst. Biol. |volume=3 |issue= |pages= 89 |year= 2007 |pmid= 17353931 |doi= 10.1038/msb4100134

External links

* [http://www.signaling-gateway.org/molecule/query?afcsid=A004067 Ubr5 : Protein Overview : UCSD-Nature Molecule Pages]

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