- MED15
PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein, also known as PCQAP, or ARC105, or TIG-1, or , is a human
gene .cite web | title = Entrez Gene: PCQAP PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51586| accessdate = ]Function
The
protein encoded by this gene is a subunit of the multiprotein complexes PC2 and ARC/DRIP and may function as a transcriptional coactivator inRNA polymerase II transcription. This gene contains stretches of trinucleotide repeats and is located in the chromosome 22 region which is deleted in DiGeorge syndrome. Two transcript variants encoding different isoforms have been found for this gene. MED15 cooperates with SREBP to regulate sterol responsive gene expression, ad this regulatory action is conserved in the nematode "C. elegans" (homologues MDT-15 and SBP-1). Also in "C. elegans", MDT-15 is essential for the response to several stresses (fasting, heavy metal, toxin, and oxidative stress); at least in part the fasting response is conferred by interactions of MDT-15 withnuclear receptor s, including NHR-49.cite web | title = Entrez Gene: PCQAP PC2 (positive cofactor 2, multiprotein complex) glutamine/Q-rich-associated protein| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51586| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Taubert S, Hansen M, Van Gilst MR, "et al." |title=The Mediator subunit MDT-15 confers metabolic adaptation to ingested material. |journal=PLoS Genet. |volume=4 |issue= 2 |pages= e1000021. |year= 2008 |pmid= 18454197 |doi=
*cite journal | author=Margolis RL, Abraham MR, Gatchell SB, "et al." |title=cDNAs with long CAG trinucleotide repeats from human brain. |journal=Hum. Genet. |volume=100 |issue= 1 |pages= 114–22 |year= 1997 |pmid= 9225980 |doi=
*cite journal | author=Näär AM, Beaurang PA, Zhou S, "et al." |title=Composite co-activator ARC mediates chromatin-directed transcriptional activation. |journal=Nature |volume=398 |issue= 6730 |pages= 828–32 |year= 1999 |pmid= 10235267 |doi= 10.1038/19789
*cite journal | author=Taubert S, Van Gilst MR, Hansen M, "et al." |title=A Mediator subunit, MDT-15, integrates regulation of fatty acid metabolism by NHR-49-dependent and -independent pathways in C. elegans. |journal=Genes Dev |volume=20 |issue=9 |pages= 1137-49|year= 2006 |pmid= 16651656 |doi =
*cite journal | author=Abraham S, Solomon WB |title=A novel glutamine-rich putative transcriptional adaptor protein (TIG-1), preferentially expressed in placental and bone-marrow tissues. |journal=Gene |volume=255 |issue= 2 |pages= 389–400 |year= 2000 |pmid= 11024300 |doi=
*cite journal | author=Berti L, Mittler G, Przemeck GK, "et al." |title=Isolation and characterization of a novel gene from the DiGeorge chromosomal region that encodes for a mediator subunit. |journal=Genomics |volume=74 |issue= 3 |pages= 320–32 |year= 2001 |pmid= 11414760 |doi= 10.1006/geno.2001.6566
*cite journal | author=Kato Y, Habas R, Katsuyama Y, "et al." |title=A component of the ARC/Mediator complex required for TGF beta/Nodal signalling. |journal=Nature |volume=418 |issue= 6898 |pages= 641–6 |year= 2002 |pmid= 12167862 |doi= 10.1038/nature00969
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=De Luca A, Conti E, Grifone N, "et al." |title=Association study between CAG trinucleotide repeats in the PCQAP gene (PC2 glutamine/Q-rich-associated protein) and schizophrenia. |journal=Am. J. Med. Genet. B Neuropsychiatr. Genet. |volume=116 |issue= 1 |pages= 32–5 |year= 2003 |pmid= 12497610 |doi= 10.1002/ajmg.b.10008
*cite journal | author=Zhang J, Liu L, Pfeifer GP |title=Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene. |journal=Oncogene |volume=23 |issue= 12 |pages= 2241–9 |year= 2004 |pmid= 14691453 |doi= 10.1038/sj.onc.1207328
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Yang F, DeBeaumont R, Zhou S, Näär AM |title=The activator-recruited cofactor/Mediator coactivator subunit ARC92 is a functionally important target of the VP16 transcriptional activator. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2339–44 |year= 2004 |pmid= 14983011 |doi=
*cite journal | author=Sato S, Tomomori-Sato C, Parmely TJ, "et al." |title=A set of consensus mammalian mediator subunits identified by multidimensional protein identification technology. |journal=Mol. Cell |volume=14 |issue= 5 |pages= 685–91 |year= 2004 |pmid= 15175163 |doi= 10.1016/j.molcel.2004.05.006
*cite journal | author=Sandhu HK, Hollenbeck N, Wassink TH, Philibert RA |title=An association study of PCQAP polymorphisms and schizophrenia. |journal=Psychiatr. Genet. |volume=14 |issue= 3 |pages= 169–72 |year= 2005 |pmid= 15318033 |doi=
*cite journal | author=Kwong J, Lo KW, Chow LS, "et al." |title=Silencing of the retinoid response gene TIG1 by promoter hypermethylation in nasopharyngeal carcinoma. |journal=Int. J. Cancer |volume=113 |issue= 3 |pages= 386–92 |year= 2005 |pmid= 15455391 |doi= 10.1002/ijc.20593
*cite journal | author=Collins JE, Wright CL, Edwards CA, "et al." |title=A genome annotation-driven approach to cloning the human ORFeome. |journal=Genome Biol. |volume=5 |issue= 10 |pages= R84 |year= 2005 |pmid= 15461802 |doi= 10.1186/gb-2004-5-10-r84
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Lim J, Hao T, Shaw C, "et al." |title=A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration. |journal=Cell |volume=125 |issue= 4 |pages= 801–14 |year= 2006 |pmid= 16713569 |doi= 10.1016/j.cell.2006.03.032
*cite journal | author=Yang F, Vought BW, Satterlee JS, "et al." |title=An ARC/Mediator subunit required for SREBP control of cholesterol and lipid homeostasis. |journal=Nature |volume=442 |issue= 7103 |pages= 700–4 |year= 2006 |pmid= 16799563 |doi= 10.1038/nature04942
*cite journal | author=Ishikawa H, Tachikawa H, Miura Y, Takahashi N |title=TRIM11 binds to and destabilizes a key component of the activator-mediated cofactor complex (ARC105) through the ubiquitin-proteasome system. |journal=FEBS Lett. |volume=580 |issue= 20 |pages= 4784–92 |year= 2006 |pmid= 16904669 |doi= 10.1016/j.febslet.2006.07.066PBB_Controls
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