ETV6

ETV6

ETV6 is an oncogene.

PBB_Summary
section_title =
summary_text = This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N-terminal pointed (PNT) domain that is involved in the protein-protein interactions with itself and other proteins, and a C-terminal DNA-binding domain. Gene knockout studies in mice suggest that it is required for hematopoiesis and maintenance of the developing vascular network. This gene is known to be involved in a large number of chromosomal rearrangements associated with leukemia and congenital fibrosarcoma. [cite web | title = Entrez Gene: ETV6 ets variant gene 6 (TEL oncogene)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2120| accessdate = ]

ee also

* TEL-JAK2

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Keung YK, Beaty M, Steward W, "et al." |title=Chronic myelocytic leukemia with eosinophilia, t(9;12)(q34;p13), and ETV6-ABL gene rearrangement: case report and review of the literature. |journal=Cancer Genet. Cytogenet. |volume=138 |issue= 2 |pages= 139–42 |year= 2003 |pmid= 12505259 |doi=
*cite journal | author=Fainstein E, Einat M, Gokkel E, "et al." |title=Nucleotide sequence analysis of human abl and bcr-abl cDNAs. |journal=Oncogene |volume=4 |issue= 12 |pages= 1477–81 |year= 1990 |pmid= 2687768 |doi=
*cite journal | author=Buijs A, Sherr S, van Baal S, "et al." |title=Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11. |journal=Oncogene |volume=10 |issue= 8 |pages= 1511–9 |year= 1995 |pmid= 7731705 |doi=
*cite journal | author=Golub TR, Barker GF, Bohlander SK, "et al." |title=Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 11 |pages= 4917–21 |year= 1995 |pmid= 7761424 |doi=
*cite journal | author=Romana SP, Mauchauffé M, Le Coniat M, "et al." |title=The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion. |journal=Blood |volume=85 |issue= 12 |pages= 3662–70 |year= 1995 |pmid= 7780150 |doi=
*cite journal | author=Papadopoulos P, Ridge SA, Boucher CA, "et al." |title=The novel activation of ABL by fusion to an ets-related gene, TEL. |journal=Cancer Res. |volume=55 |issue= 1 |pages= 34–8 |year= 1995 |pmid= 7805037 |doi=
*cite journal | author=Golub TR, Barker GF, Lovett M, Gilliland DG |title=Fusion of PDGF receptor beta to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation. |journal=Cell |volume=77 |issue= 2 |pages= 307–16 |year= 1994 |pmid= 8168137 |doi=
*cite journal | author=Wlodarska I, Baens M, Peeters P, "et al." |title=Biallelic alterations of both ETV6 and CDKN1B genes in a t(12;21) childhood acute lymphoblastic leukemia case. |journal=Cancer Res. |volume=56 |issue= 11 |pages= 2655–61 |year= 1996 |pmid= 8653712 |doi=
*cite journal | author=Baens M, Peeters P, Guo C, "et al." |title=Genomic organization of TEL: the human ETS-variant gene 6. |journal=Genome Res. |volume=6 |issue= 5 |pages= 404–13 |year= 1996 |pmid= 8743990 |doi=
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Hillier LD, Lennon G, Becker M, "et al." |title=Generation and analysis of 280,000 human expressed sequence tags. |journal=Genome Res. |volume=6 |issue= 9 |pages= 807–28 |year= 1997 |pmid= 8889549 |doi=
*cite journal | author=Andreasson P, Johansson B, Arheden K, "et al." |title=Deletions of CDKN1B and ETV6 in acute myeloid leukemia and myelodysplastic syndromes without cytogenetic evidence of 12p abnormalities. |journal=Genes Chromosomes Cancer |volume=19 |issue= 2 |pages= 77–83 |year= 1997 |pmid= 9171997 |doi=
*cite journal | author=Lacronique V, Boureux A, Valle VD, "et al." |title=A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia. |journal=Science |volume=278 |issue= 5341 |pages= 1309–12 |year= 1997 |pmid= 9360930 |doi=
*cite journal | author=Knezevich SR, McFadden DE, Tao W, "et al." |title=A novel ETV6-NTRK3 gene fusion in congenital fibrosarcoma. |journal=Nat. Genet. |volume=18 |issue= 2 |pages= 184–7 |year= 1998 |pmid= 9462753 |doi= 10.1038/ng0298-184
*cite journal | author=Kwiatkowski BA, Bastian LS, Bauer TR, "et al." |title=The ets family member Tel binds to the Fli-1 oncoprotein and inhibits its transcriptional activity. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17525–30 |year= 1998 |pmid= 9651344 |doi=
*cite journal | author=Hannemann JR, McManus DM, Kabarowski JH, Wiedemann LM |title=Haemopoietic transformation by the TEL/ABL oncogene. |journal=Br. J. Haematol. |volume=102 |issue= 2 |pages= 475–85 |year= 1998 |pmid= 9695962 |doi=
*cite journal | author=Chakrabarti SR, Sood R, Ganguly S, "et al." |title=Modulation of TEL transcription activity by interaction with the ubiquitin-conjugating enzyme UBC9. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 13 |pages= 7467–72 |year= 1999 |pmid= 10377438 |doi=
*cite journal | author=Cools J, Bilhou-Nabera C, Wlodarska I, "et al." |title=Fusion of a novel gene, BTL, to ETV6 in acute myeloid leukemias with a t(4;12)(q11-q12;p13). |journal=Blood |volume=94 |issue= 5 |pages= 1820–4 |year= 1999 |pmid= 10477709 |doi=
*cite journal | author=Yagasaki F, Jinnai I, Yoshida S, "et al." |title=Fusion of TEL/ETV6 to a novel ACS2 in myelodysplastic syndrome and acute myelogenous leukemia with t(5;12)(q31;p13). |journal=Genes Chromosomes Cancer |volume=26 |issue= 3 |pages= 192–202 |year= 2000 |pmid= 10502316 |doi=
*cite journal | author=Wai DH, Knezevich SR, Lucas T, "et al." |title=The ETV6-NTRK3 gene fusion encodes a chimeric protein tyrosine kinase that transforms NIH3T3 cells. |journal=Oncogene |volume=19 |issue= 7 |pages= 906–15 |year= 2000 |pmid= 10702799 |doi= 10.1038/sj.onc.1203396

External links

*

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • TEL-JAK2 — is a gene fusion resulting from a chromosomal translocation between chromosomes 9 and 12 observed in human leukemia [cite journal | author=Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, Mauchauffe M, Berthou C, Lessard M, Berger R,… …   Wikipedia

  • ETV7 — Ets variant gene 7 (TEL2 oncogene), also known as ETV7, is a human gene.cite web | title = Entrez Gene: ETV7 ets variant gene 7 (TEL2 oncogene)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=51513|… …   Wikipedia

  • Minimal residual disease — (MRD) is the name given, to small numbers of leukaemic cells that remain in the patient during treatment, or after treatment when the patient is in remission (no symptoms or signs of disease). It is the major cause of relapse in cancer and… …   Wikipedia

  • Cancer research — This article is about research into cancer, in general. For the UK based charity, see Cancer Research UK. For the journal, see Cancer Research (journal). University of Florida Cancer Hospital Cancer research is basic research into cancer in order …   Wikipedia

  • Abl gene — The abl gene is associated with chronic myelogenous leukemia (CML). The abl gene is located on the 9th chromosome. In CML, the gene is activated by being translocated within the bcr (breakpoint cluster region) gene on chromosome 22. This new… …   Wikipedia

  • Janus kinase 2 — Jak2 has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM CSF receptor family (IL 3R, IL 5R and GM CSF R), the gp130 receptor family (e.g IL 6R), and the single chain receptors (e …   Wikipedia

  • PIK3R1 — Phosphoinositide 3 kinase, regulatory subunit 1 (alpha) PDB rendering based on 1bfi …   Wikipedia

  • PDGFRB — Platelet derived growth factor receptor, beta polypeptide Ribbon image of two molecules of human PDGF receptor beta (yellow and magenta) in complex with dimeric PDGF B (cyan and green).[1] …   Wikipedia

  • NTRK3 — Neurotrophic tyrosine kinase, receptor, type 3, also known as NTRK3, is a human gene. PBB Summary section title = summary text = This gene encodes a member of the neurotrophic tyrosine receptor kinase (NTRK) family. This kinase is a membrane… …   Wikipedia

  • LRP6 — Low density lipoprotein receptor related protein 6, also known as LRP6, is a human gene.cite web | title = Entrez Gene: LRP6 low density lipoprotein receptor related protein 6| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”