TEL-JAK2

TEL-JAK2

TEL-JAK2 is a gene fusion resulting from a chromosomal translocation between chromosomes 9 and 12 observed in human leukemia [cite journal | author=Lacronique V, Boureux A, Valle VD, Poirel H, Quang CT, Mauchauffe M, Berthou C, Lessard M, Berger R, Ghysdael J, Bernard OA | title=A TEL-JAK2 fusion protein with constitutive kinase activity in human leukemia | journal=Science | year=1997 | pages=1309–12 | volume=278 | issue=5341 | pmid=9360930 | doi=10.1126/science.278.5341.1309] [cite journal | author=Peeters P, Raynaud SD, Cools J, Wlodarska I, Grosgeorge J, Philip P, Monpoux F, Van Rompaey L, Baens M, Van den Berghe H, Marynen P | title=Fusion of TEL, the ETS-variant gene 6 (ETV6), to the receptor-associated kinase JAK2 as a result of t(9;12) in a lymphoid and t(9;15;12) in a myeloid leukemia | journal=Blood | year=1997 | pages=2535–40 | volume=90 | issue=7 | pmid=9326218] . The 5' moiety of "TEL" is fused to the 3' end of "JAK2".

The oligomerisation domain of the TEL protein (also called ETV6) becomes juxtaposed to the tyrosine kinase domain of JAK2, and as result the TEL-JAK2 displays constitutive kinase activity.

References

External links

*


Wikimedia Foundation. 2010.

Игры ⚽ Нужно решить контрольную?

Look at other dictionaries:

  • Janus kinase 2 — Jak2 has been implicated in signaling by members of the type II cytokine receptor family (e.g. interferon receptors), the GM CSF receptor family (IL 3R, IL 5R and GM CSF R), the gp130 receptor family (e.g IL 6R), and the single chain receptors (e …   Wikipedia

  • Janus kinase 2 — La Janus kinase 2 (JAK2) est une protéine de type tyrosine kinase impliquée dans plusieurs voies de signalisation responsables principalement de la survie et de la prolifération cellulaire. JAK2 est liée aux récepteurs de la famille des cytokines …   Wikipédia en Français

  • ETV6 — is an oncogene. PBB Summary section title = summary text = This gene encodes an ETS family transcription factor. The product of this gene contains two functional domains: a N terminal pointed (PNT) domain that is involved in the protein protein… …   Wikipedia

  • Fusion gene — A fusion gene is a hybrid gene formed from two previously separate genes. It can occur as the result of a translocation, interstitial deletion, or chromosomal inversion. The fusion of two genes is often taken as evidence that these genes have… …   Wikipedia

  • STAT5A — Signal transducer and activator of transcription 5A, also known as STAT5A, is a human gene. PBB Summary section title = summary text = The protein encoded by this gene is a member of the STAT family of transcription factors. In response to… …   Wikipedia

  • ETS transcription factor family — In the field of molecular biology, the ETS family is one of the largest families of transcription factors and is unique to metazoans. There are 27 genes in humans, 26 in the mouse, 10 in Caenorhabditis elegans and 9 in Drosophila. The founding… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”