2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase

In enzymology, a 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase (EC number|4.6.1.12) is an enzyme that catalyzes the chemical reaction

:2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol $ightleftharpoons$ 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP

Hence, this enzyme has one substrate, 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, and two products, 2-C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP.

This enzyme belongs to the family of lyases, specifically phosphorus-oxygen lyases. The systematic name of this enzyme class is 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming). Other names in common use include MECDP-synthase, 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol, and CMP-lyase (cyclizing). This enzyme participates in biosynthesis of steroids.

tructural studies

As of late 2007, 20 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1GX1, PDB link|1H47, PDB link|1H48, PDB link|1IV1, PDB link|1IV2, PDB link|1IV3, PDB link|1IV4, PDB link|1T0A, PDB link|1U3L, PDB link|1U3P, PDB link|1U40, PDB link|1U43, PDB link|1VH8, PDB link|1VHA, PDB link|1W55, PDB link|1W57, PDB link|1YQN, PDB link|2AMT, PDB link|2GZL, and PDB link|2PMP.

References

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External links

Gene Ontology (GO) codes