NPR3

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
Available structures PDB 1yk0, 1jdp, 1yk1, 1jdn
Identifiers
Symbols	NPR3; GUCY2B; NPRC; ANPRC
External IDs	OMIM: 108962 MGI: 97373 HomoloGene: 699 GeneCards: NPR3 Gene
Gene Ontology Molecular function • peptide receptor activity, G-protein coupled • chloride ion binding • natriuretic peptide receptor activity • receptor activity • peptide hormone binding • protein homodimerization activity Cellular component • membrane • integral to membrane • membrane fraction Biological process • inhibition of adenylate cyclase activity by G-protein signaling • regulation of blood pressure • activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger • skeletal system development Sources: Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	4883	18162
Ensembl	ENSG00000113389	ENSMUSG00000022206
UniProt	P17342	P70180
RefSeq (mRNA)	NM_000908	NM_008728
RefSeq (protein)	NP_000899	NP_001034270
Location (UCSC)	Chr 5: 32.71 – 32.79 Mb	Chr 15: 11.77 – 11.84 Mb
PubMed search	[1]	[2]

Natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C), also known as NPR3, is an atrial natriuretic peptide receptor. In humans it is encoded by the NPR3 gene.^[1]

Function

The family of natriuretic peptides elicit a number of vascular, renal, and endocrine effects that are important in the maintenance of blood pressure and extracellular fluid volume. These effects are mediated by specific binding of the peptides to cell surface receptors in the vasculature, kidney, adrenal, and brain.^[1]

References

1. ^ ^{a b} "Entrez Gene: NPR3 natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4883. 

Further reading

• Fox AA, Collard CD, Shernan SK, et al. (2009). "Natriuretic peptide system gene variants are associated with ventricular dysfunction after coronary artery bypass grafting.". Anesthesiology 110 (4): 738–47. doi:10.1097/ALN.0b013e31819c7496. PMC 2735337. PMID 19326473. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2735337. 
• Moffatt P, Thomas G, Sellin K, et al. (2007). "Osteocrin is a specific ligand of the natriuretic Peptide clearance receptor that modulates bone growth.". J. Biol. Chem. 282 (50): 36454–62. doi:10.1074/jbc.M708596200. PMID 17951249. 
• Pitzalis MV, Sarzani R, Dessì-Fulgheri P, et al. (2003). "Allelic variants of natriuretic peptide receptor genes are associated with family history of hypertension and cardiovascular phenotype.". J. Hypertens. 21 (8): 1491–6. doi:10.1097/01.hjh.0000084707.87421.35. PMID 12872042. 
• Fan D, Bryan PM, Antos LK, et al. (2005). "Down-regulation does not mediate natriuretic peptide-dependent desensitization of natriuretic peptide receptor (NPR)-A or NPR-B: guanylyl cyclase-linked natriuretic peptide receptors do not internalize.". Mol. Pharmacol. 67 (1): 174–83. doi:10.1124/mol.104.002436. PMID 15459247. 
• He Xl , Chow Dc , Martick MM, Garcia KC (2001). "Allosteric activation of a spring-loaded natriuretic peptide receptor dimer by hormone.". Science 293 (5535): 1657–62. doi:10.1126/science.1062246. PMID 11533490. 
• Soranzo N, Rivadeneira F, Chinappen-Horsley U, et al. (2009). Visscher, Peter M.. ed. "Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.". PLoS Genet. 5 (4): e1000445. doi:10.1371/journal.pgen.1000445. PMC 2661236. PMID 19343178. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2661236. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. 
• He XL, Dukkipati A, Garcia KC (2006). "Structural determinants of natriuretic peptide receptor specificity and degeneracy.". J. Mol. Biol. 361 (4): 698–714. doi:10.1016/j.jmb.2006.06.060. PMID 16870210. 
• Rubattu S, Stanzione R, Di Angelantonio E, et al. (2004). "Atrial natriuretic peptide gene polymorphisms and risk of ischemic stroke in humans.". Stroke 35 (4): 814–8. doi:10.1161/01.STR.0000119381.52589.AB. PMID 15017020. 
• Iemitsu M, Maeda S, Otsuki T, et al. (2008). "Arterial stiffness, physical activity, and atrial natriuretic Peptide gene polymorphism in older subjects.". Hypertens. Res. 31 (4): 767–74. doi:10.1291/hypres.31.767. PMID 18633189. 
• Dickey DM, Yoder AR, Potter LR (2009). "A familial mutation renders atrial natriuretic Peptide resistant to proteolytic degradation.". J. Biol. Chem. 284 (29): 19196–202. doi:10.1074/jbc.M109.010777. PMC 2740543. PMID 19458086. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2740543. 
• Gratacòs M, Costas J, de Cid R, et al. (2009). "Identification of new putative susceptibility genes for several psychiatric disorders by association analysis of regulatory and non-synonymous SNPs of 306 genes involved in neurotransmission and neurodevelopment.". Am. J. Med. Genet. B Neuropsychiatr. Genet. 150B (6): 808–16. doi:10.1002/ajmg.b.30902. PMID 19086053. 
• Aoi N, Soma M, Nakayama T, et al. (2004). "Variable number of tandem repeat of the 5'-flanking region of type-C human natriuretic peptide receptor gene influences blood pressure levels in obesity-associated hypertension.". Hypertens. Res. 27 (10): 711–6. doi:10.1291/hypres.27.711. PMID 15785005. 
• Anand-Srivastava MB (2005). "Natriuretic peptide receptor-C signaling and regulation.". Peptides 26 (6): 1044–59. doi:10.1016/j.peptides.2004.09.023. PMID 15911072. 
• Estrada K, Krawczak M, Schreiber S, et al. (2009). "A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.". Hum. Mol. Genet. 18 (18): 3516–24. doi:10.1093/hmg/ddp296. PMC 2729669. PMID 19570815. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2729669. 
• Burgess MD, Moore KD, Carter GM, et al. (2009). "C-type natriuretic peptide receptor expression in pancreatic alpha cells.". Histochem. Cell Biol. 132 (1): 95–103. doi:10.1007/s00418-009-0591-3. PMID 19352691. 
• Vassalle C, Andreassi MG, Prontera C, et al. (2007). "Influence of ScaI and natriuretic peptide (NP) clearance receptor polymorphisms of the NP System on NP concentration in chronic heart failure.". Clin. Chem. 53 (11): 1886–90. doi:10.1373/clinchem.2007.088302. PMID 17890443. 
• Lee JK, Kim HT, Cho SM, et al. (2003). "Characterization of 458 single nucleotide polymorphisms of disease candidate genes in the Korean population.". J. Hum. Genet. 48 (5): 213–6. doi:10.1007/s10038-003-0011-9. PMID 12768436. 
• van den Akker F (2001). "Structural insights into the ligand binding domains of membrane bound guanylyl cyclases and natriuretic peptide receptors.". J. Mol. Biol. 311 (5): 923–37. doi:10.1006/jmbi.2001.4922. PMID 11556325. 
• He XL, Dukkipati A, Wang X, Garcia KC (2005). "A new paradigm for hormone recognition and allosteric receptor activation revealed from structural studies of NPR-C.". Peptides 26 (6): 1035–43. doi:10.1016/j.peptides.2004.08.035. PMID 15911071. 

See also

• Atrial natriuretic peptide receptor

External links

• MeSH NPR2+protein,+human

1jdp: Crystal Structure of Hormone/Receptor Complex

1yk1: structure of natriuretic peptide receptor-C complexed with brain natriuretic peptide

1jdn: Crystal Structure of Hormone Receptor