Phospholipase C

Phospholipase C

Phospholipase C is a class of enzymes that cleave phospholipids just before the phosphate group (see Figure). It is most commonly taken to be synonymous with the human forms of this enzyme, EC number|3.1.4.11, which plays an important role in eukaryotic cell physiology, particularly signal transduction pathways. However, other phospholipase C enzymes have been identified in bacteria and in trypanosomes, each with their own EC number.

* Phosphoinositide phospholipase C EC number|3.1.4.11 The main form found in eukaryotes, especially mammals.

* Zinc dependent phospholipase C family of bacterial enzymes EC number|3.1.4.3 that includes alpha toxins

* Phosphatidylinositol diacylglycerol-lyase EC number|4.6.1.13 Another related bacterial enzyme.

* Glycosylphosphatidylinositol diacylglycerol-lyase EC number|4.6.1.14 A trypanosomal enzyme.


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