:"For the related metabolic process, see
Catabolism is the set of
metabolic pathways which break down molecules into smaller units and release energy. [cite web |url=http://www.chem.qmul.ac.uk/iupac/bioinorg/CD.html#8 |title=Glossary of Terms Used in Bioinorganic Chemistry: Catabolism |accessdate=2007-10-30 |last=de Bolster |first=M.W.G. |date=1997 |publisher=International Union of Pure and Applied Chemistry] In catabolism, large molecules such as polysaccharides, lipids, nucleic acids and proteins are broken down into smaller units such as monosaccharides, fatty acids, nucleotides and amino acids, respectively. As molecules such as polysaccharides, proteins and nucleic acids are made from long chains of these small monomerunits, the large molecules are called polymers.
Cells use the
monomersreleased from breaking down polymers to either construct new polymer molecules, or degrade the monomers further to simple waste products, releasing energy. Cellular wastes include lactic acid, acetic acid, carbon dioxide, ammonia, and urea. The creation of these wastes is usually an oxidationprocess involving a release of chemical free energy, some of which is lost as heat, but the rest is used to drive the synthesis of adenosine triphosphate(ATP). This molecule acts as a way for the cell to transfer the energy released by catabolism to the energy-requiring reactions which make up anabolism. Catabolism therefore provides the chemical energy necessary for the maintenance and growth of cells. Examples of catabolic processes include glycolysis, the citric acid cycle, the breakdown of muscle protein in order to use amino acids as substrates for gluconeogenesisand breakdown of fatin adipose tissueto fatty acids.
There are many signals which control catabolism. Most of the known signals are
hormones and the molecules involved in metabolism itself. Endocrinologists have traditionally classified many of the hormones as anabolicor catabolic, depending on which part of metabolism they stimulate. The "classic" catabolic hormones known since the early 20th century are cortisol, glucagon, and adrenaline(and other catecholamines). In recent decades, many more hormones with at least some catabolic effects have been discovered, including cytokines, orexinand hypocretin(a hormone pair), and melatonin.
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