Life extension

Life extension refers to an increase in maximum or average lifespan, especially in humans, by slowing down or reversing the processes of aging. Average lifespan is determined by vulnerability to accidents and age-related afflictions such as cancer or cardiovascular disease. Extension of average lifespan can be achieved by good diet, exercise and avoidance of hazards such as smoking. Maximum lifespan is determined by the rate of aging for a species inherent in its genes and probably by certain environmental factors. Currently, the only widely recognized method of extending maximum lifespan is calorie restriction. Theoretically, extension of maximum lifespan could be achieved by reducing the rate of aging damage, by periodic replacement of damaged tissues, or by molecular repair or rejuvenation of deteriorated cells and tissues.

Researchers of life extension are known as biogerontologists. They seek to understand the nature of aging and they develop treatments to reverse aging processes or to at least slow them down, for the improvement of health and the maintenance of youthful vigor at every stage of life. (Biomedical gerontologists are distinguished from biogerontologists in that the latter may take a purely academic interest in the biological mechanisms of aging, without seeking a "cure".) Those who take advantage of life extension findings and seek to apply them upon themselves are called "life extensionists" or "longevists". The primary life extension strategy currently is to apply available anti-aging methods in the hope of living long enough to benefit from a complete cure to aging once it is developed. Raymond Kurzweil, a somewhat controversial futurist and transhumanist, believes that the rapidly advancing state of biogenetic and general medical technology could make this possible by approximately 2020. [Ray Kurzweil, "The Singularity is Near (When Humans Transcend Biology)" (2005), Penguin Books ISBN 0-14-30.3788-9]

Many biomedical gerontologists and life extensionists believe that future breakthroughs in tissue rejuvenation with stem cells, organs replacement (with artificial organs or xenotransplantations) and molecular repair will eliminate all aging and disease as well as allow for complete rejuvenation to a youthful condition. Whether such breakthroughs can occur within the next few decades is impossible to predict. Many life extensionists arrange to be cryonically preserved upon legal death so that they can await the time when future medicine can eliminate disease, rejuvenate them to a lasting youthful condition and repair damage caused by the cryonics process.Fact|date=June 2007

Whether the maximum human lifespan should be extended is the subject of much ethical debate amongst politicians and scientists. But the life extension movement, which began in the early 1980s, continues to grow rapidly in popularity and momentum among scientists and the general public.Fact|date=April 2007

Aging

Aging is an accumulation of damage to macromolecules, cells, tissues and organs. The maximum life span known for humans may be in excess of 120 years, whereas the maximum lifespan of a mouse, commonly used as a model in research on aging, is about four years. Genetic differences between humans and mice that may account for these different aging rates include efficiency of DNA repair, types and quantities of antioxidant enzymes, and different rates of free radical production.

trategies of life extension

Anti-aging nutrition and medicine

Much of anti-aging medicine has been concerned with the use of nutritional supplements to extend lifespan. The idea that antioxidant supplements, such as Vitamin C, Vitamin E, lipoic acid and N-acetylcysteine, might extend human life stems from the free radical theory of aging. Other less popular hormones are oxytocin, insulin, human chorionic gonadotropin (hCG), erythropoietin (EPO), and others. Resveratrol is a sirtuin stimulant proposed to extend life in mammals in a similar manner to that claimed for calorie restriction in simple model organisms such as nematodes. Fact|date=January 2008

Some supplements have been shown to be of benefit against some aging-related disease conditions, or have extended average lifespan in animals, though none have been proven to do so in humans. Calorie restriction and supplementation with the minerals selenium,"Selenium and tellurium in rats: effect on growth, survival and tumors." Schroeder HA, Mitchener M in J Nutr. 1971 Nov; 101(11): 1531-40 (PMID 5124041) The selenate dose used (3ppm) was toxic (carcinogenic); despite this the mean LS was extended by 9%, maximum cohort LS by 48%., which at 60 months beat the previous species maximum of 42 months by 43%. (Selenite at 3ppm was highly toxic and not pursued.) The ratio of max cohort LS / control mean LS was 2.25. (cf: control max/mean LS = 1.52) The controls received 50ug/kg selenium / wet diet weight.] chromium"Longevity effect of chromium picolinate--'rejuvenation' of hypothalamic function? " McCarty MF in Med Hypotheses 1994 Oct;43(4):253-65 (PMID 7838011) “The first rodent longevity study with the insulin-sensitizing nutrient chromium picolinate has reported a dramatic increase in both median and maximal lifespan..” Gives additional information about the Evans-Meyer-Pouchnik (PMID 8433089) chromium picolinate experiment on rats: Cohort maximum lifespan (last survivor) was 48 months, extending the previous species maximum by 15% to give a total maximum lifespan increase of 26%. ] and zinc"Presence of links between zinc and melatonin during the circadian cycle in old mice: effects on thymic endocrine activity and on the survival." Mocchegiani E, Santarelli L, Tibaldi A, Muzzioli M, Bulian D, Cipriano K, Olivieri F, Fabris N. in J Neuroimmunol. 1998 Jun 15;86(2):111-22. (PMID 9663556) Median lifespan extension 39%; max lifespan extension 10% (relative to the controls) for the zinc sulphate mice who received 22mg/L = 4.83 mg zinc/L in their water; intervention started at 18 months, median control died at 22 months; controls and test mice received slightly more zinc in their food; i.e. test mice received slightly less than twice the amount of zinc as the control mice received. Total human equivalent zinc intake = 11mg/d. See (PMID 8582782) full text for more details on water and food intake levels; zinc sulphate = Zn S04 . 7(H2O); 22.7% zinc by wt. 22mg zinc suphate = 5mg zinc. The zinc sulphate mice also outlived the melatonin- supplemented mice. Zinc and melatonin levels were correlated in both the zinc and melatonin supplemented mice.] have been shown to extend maximum lifespan in mice. Metformin" Exp Gerontol. 2005 Aug-Sep;40(8-9):685-93. Effect of metformin on life span and on the development of spontaneous mammary tumors in HER-2/neu transgenic mice.Anisimov VN, Berstein LM, Egormin PA, Piskunova TS, Popovich IG, Zabezhinski MA, Kovalenko IG, Poroshina TE, Semenchenko AV, Provinciali M, Re F, Franceschi C. (PMID: 16125352)"] may also extend life span in mice, and in the first experiments with fish, resveratrol"Curr Biol. 2006 Feb 7;16(3):296-300. Resveratrol prolongs lifespan and retards the onset of age-related markers in a short-lived vertebrate. Valenzano DR, Terzibasi E, Genade T, Cattaneo A, Domenici L, Cellerino A. (PMID: 16461283)"] looks promising. (Resveratrol is presently (2006) being tested in mice.)

Scientific controversy regarding anti-aging nutritional supplementation and medicine

Although Alex Comfort and Bernard Strehler have been retrospectively claimed as anti-aging gerontologists, other biogerontologists vehemently deny that aging is a disease. Possibly the most prominent biogerontologist making this denial is Leonard Hayflick, who determined that fibroblasts are limited to around 50 cell divisions. Hayflick reasons that aging is an unavoidable consequence of entropy.

Dr. Denham Harman spent years experimenting with antioxidants, and was able to establish only that they can extend mean lifespan; he was unable to demonstrate an effect on maximum lifespan. Non-antioxidant nutrients (such as selenium, chromium"Longevity effect of chromium picolinate--'rejuvenation' of hypothalamic function? " McCarty MF in Med Hypotheses 1994 Oct;43(4):253-65 (PMID 7838011) “The first rodent longevity study with the insulin-sensitizing nutrient chromium picolinate has reported a dramatic increase in both median and maximal lifespan..” Gives additional information about the Evans-Meyer-Pouchnik (PMID 8433089) chromium picolinate experiment on rats: Cohort maximum lifespan (last survivor) was 48 months, extending the previous species maximum by 15% to give a total maximum lifespan increase of 26%. ] and zinc"Presence of links between zinc and melatonin during the circadian cycle in old mice: effects on thymic endocrine activity and on the survival." Mocchegiani E, Santarelli L, Tibaldi A, Muzzioli M, Bulian D, Cipriano K, Olivieri F, Fabris N. in J Neuroimmunol. 1998 Jun 15;86(2):111-22. (PMID 9663556) Median lifespan extension 39%; max lifespan extension 10% (relative to the controls) for the zinc sulphate mice who received 22mg/L = 4.83 mg zinc/L in their water; intervention started at 18 months, median control died at 22 months; controls and test mice received slightly more zinc in their food; i.e. test mice received slightly less than twice the amount of zinc as the control mice received. Total human equivalent zinc intake = 11mg/d. See (PMID 8582782) full text for more details on water and food intake levels; zinc sulphate = Zn S04 . 7(H2O); 22.7% zinc by wt. 22mg zinc suphate = 5mg zinc. The zinc sulphate mice also outlived the melatonin- supplemented mice. Zinc and melatonin levels were correlated in both the zinc and melatonin supplemented mice.] ) are more effective and have extended maximum lifespan. In response to what they saw as unscrupulous profiteering by thoseengaged in the selling of supplements and the practice of anti-aging medicine, a group of prominent biogerontologists began a "war" on anti-aging medicine in general and the A4M in particular. Jay Olshansky, Leonard Hayflick, and Bruce Carnes wrote a position paper against anti-aging medicine. [cite journal | author=Olshansky SJ, Hayflick L, Carnes BA. | title=Position statement on human aging | journal=The Journals of Gerontology, Series A: Biological Sciences and Medical Sciences | year=2002 | volume=57 | issue=8 | pages=B292–B297 | pmid=12145354 ]

Ethics and politics of anti-aging nutritional supplementation and medicine

Politics relevant to the substances of life extension pertain mostly to communications and availability. In the United States, the claims which can be made on food and drug product labels are strictly regulated. Meanwhile, freedom of speech guaranteed by the First Amendment currently only protects the right of third-party publishers to print books, newsletters, websites, etc. on every aspect of these substances, including opinions, speculations, etc. Many manufacturers and suppliers also provide publications, but because they are also marketing the substances, they are subject to the monitoring and enforcement efforts of the Federal Trade Commission (FTC) which has jurisdiction over false claims made by marketers in public media. What constitutes the difference between truthful and false claims is hotly debated and is a central controversy in this arena.

Calorie restriction

The restriction of energy intake, or calories, in an otherwise healthy diet (a practice generally called "Calorie restriction" or simply "CR") has been shown to extend the maximum life span of almost every species on which it has been tested, including rats, yeast, fruit flies, and nematodes. In rodents, a roughly 50% maximum lifespan extension is seen with a roughly 50% restriction of calories from what would be consumed by freely-feeding animals. Experiments are in progress with primates to test whether calorie restriction can extend the lifespan of primates. Some people believe that these experiments will be successful, and further believe that the results will be also true for humans. A group called the Calorie Restriction Society was formed with the help of Brian M. Delaney, Lisa Walford, and Roy Walford in the mid-1990s. They have been flown to Washington University in St. Louis to be studied by Dr. John Holloszy. Calorie restriction is under current study at the UW-Madison and several other universities. Fact|date=May 2008

Scientific controversy regarding calorie restriction

Despite the results on yeast, fruit flies and nematodes, criticisms have been raised that the results of calorie restriction experiments on laboratory rats are not generalizable because years of inbreeding have made these animals different from those found in the wild. Even if it is conceded that the rat work may be generalizable to some extent, some argue that the results are applicable only to short-lived species that have evolved to respond to feast and famine with alterations in longevity. Proving that the results are generalizable in a way that encourages hope of extended life for human beings is difficult, because experiments with long-lived species necessarily take a very long time to perform.

Scientists have varying theories on why calorie restriction experiments would increase the life spans of the test animals. These include the habitat, the genetic line of the test subjects, and the nutritional content of the animal's diets, and the frequencies of feeding. Some critics observe that the test animals are not exposed to the same stresses that humans are in everyday life in modern environments, which may give humans a greater need for the calories.

Chemical and genetic interventions in non-human animals

Resveratrol is a substance that has been shown to extend the lifespan of yeast, fruit flies, certain fish, and rats. Other experiments in mammals are currently underway. The manner by which resveratrol achieves this effect remains unknown, although it has been conjectured that it is involved in the mechanism that underlies the lifespan enhancing effects of calorie restriction.

The evidence for use of growth hormone is mixed. An early [http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2002700 study] suggested that supplementation of mice with growth hormone increased average life expectancy. Additional animal [http://biomed.gerontologyjournals.org/cgi/content/abstract/61/6/562 experiments] have suggested that growth hormone may generally act to shorten maximum lifespan; knockout mice lacking the receptor for growth hormone live especially long.

Likewise, the Sir2 class of genes is conjectured to be involved in the calorie restriction mechanism; yeast genetically engineered to overexpress Sir2 live longer.

Large availability of insulin generally leads to shorter lifespan. Mice genetically engineered to lack an insulin receptor in fat tissue live longer. Mice with an overexpression of the Klotho gene, which limits insulin sensitivity, also show an extended lifespan.

Recently (2008), in an experience presented in a program of Portuguese television (RTP - ABciência - elixir da imortalidade), it was demonstrated, for the first time, that it is possible to immortalize yeast cells thanks to the effect of a vegetable extractClarifyme|date=October 2008. The plant biomolecules protect the cells in fatal conditions of oxidative and thermal stresses. This vegetable extract is seven times more powerful than resveratrol in the extension of the yeast chronological lifespanFact|date=October 2008.

Potential future strategies of life extension

Cloning and body part replacement

Biotechnologies, particularly those of human cloning and stem cell research, are thought to offer some possibility of replacing aging body parts with 'new' parts grown artificially. Current technology has already demonstrated the feasibility of body part replacement in laboratory experiments, most notably the fabrication of a functioning dog's bladder that proved to be viable after successful implantation. Bladders and other simple biological structures more readily lend themselves to artificial fabrication, whereas complex biological structures such as mammalian joints and limbs are not yet possible to fabricate artificially. Given the exponential progression of technology, it is probable that the artificial fabrication of replacement body parts, both simple and complex, along with successful implantation technology will one day be possible. In one popular scenario, an individual's brain is transplanted from his or her aging body into a new, youthful body cloned from his or her own tissues. Experiments were conducted in the mid-20th century to transplant brains from one body to another (conducted in both monkeys and dogs), but failed due to rejection and the inability to restore nerve connections - research into the nervous system and homogenisation may make this process more fruitful in the future. Proponents of body part replacement and cloning contend that the required biotechnologies are likely to appear earlier than other life-extension technologies.

Recently, the US Department of Defense has initiated a program to regrow human body parts on mice, which could be removed and attached to the amputee. [ [http://www.foxnews.com/story/0,2933,353884,00.html FOXNews.com - Breakthroughs In Tissue Regrowth Give Hope to War Wounded - Health News | Current Health News | Medical News ] ]

Moral controversy surrounding stem cell research and human cloning continues to cloud the issue.

Ethics and politics of cloning and stem cell research

The use of human stem cells, particularly embryonic stem cells is controversial and contentious. Opponents' objections generally are based on interpretations of religious teachings and ideas about the sanctity of life, as in practice, use of stem cell research gives the impression of "take a life to further your own". However, proponents of stem cell research point out that cells are routinely formed and destroyed in a variety of contexts.

Similarly, therapeutic cloning is a way to generate cells, body parts, or in theory even whole bodies (generally referred to as reproductive cloning) genetically identical to a prospective patient. The controversies over cloning are similar to those over embryonic stem cell research, except general public opinion in most countries stands in even greater opposition to reproductive cloning. However, some proponents of therapeutic cloning argue that production of a never-conscious cloned soma might be the most successful and compassionate form of therapeutic cloning.

Cryonics

Cryonics is inspired by the fact that life extension technologies may eventually allow people to live thousands of years of youthful life. But these technologies may not be available for another 50 years, if ever. There is a danger that anyone, including young people, may die before the new medicine becomes available. Cryopreservation shortly after legal death may provide an "ambulance" into the future. The basis of cryonics is that at cryogenic temperatures there will be no alteration in biological tissue for thousands of years, which allows plenty of time for future medicine to achieve the required capabilities.

For those in cryonics, future medicine will not only be able to cure all disease and rejuvenate everyone to a youthful condition, but it will be able to repair any damage that is caused by the cryopreservation process. Molecular repair technology (nanotechnology and nanomedicine) is expected to be able to achieve these results. But to be safe, and to minimize damage, efforts have been made to eliminate all freezing damage through vitrification and to minimize ischemic damage through rapid cooling and cardio-pulmonary support immediately following pronouncement of death.

Cryonics is not freezing of humans or animals. Ice is very damaging to body tissues, so all cryonics organizations use cryoprotectants to prevent ice formation, i.e., anti-freeze substances that can reduce or prevent ice formation. Formerly cryonics organizations used glycerol as their cryoprotectant, which resulted in about 80% ice elimination (vitrification) and about 20% freezing. Cryonicists believed that damage that was being caused by disease, by aging and by the freezing would someday be repaired by nanotechnology. With vitrification the burden on future technology has been greatly reduced. With cells and tissues mainly preserved by cooling, future technology should be able to repair damage resulting if the cooling process is not too delayed.

Since the 1990s vitrification solutions have been developed that have virtually eliminated ice formation (reduced to less than 0.2%). In fact, it was announced in July 2005 that one such solution had been used to vitrify rabbit kidney at −135°C, and was later transplanted into a rabbit with full viability.

Stoppage of heartbeat and breathing, the usual criteria for legal death, do not correspond to the death of cells and tissues of the body. The cells and tissues are still very much alive when death is pronounced. Even at room temperature cells and tissues take hours to die, and days to decompose. Although neurological damage is the usual consequence of cessation of heartbeat for more than 4-6 minutes, the irreversible neurodegenerative processes do not manifest for hours.cite journal
author=Garcia JH, Liu KF, Ho KL
title=Neuronal Necrosis After Middle Cerebral Artery Occlusion in Wistar Rats Progresses at Different Time Intervals in the Caudoputamen and the Cortex
journal=Stroke
volume=26
issue=4
year=1995
pages=636–643 |url=http://stroke.ahajournals.org/cgi/content/full/26/4/636
pmid=7709411

Rapid cooling and cardio-pulmonary support applied immediately after pronouncement of death can preserve cells and tissues for long-term preservation at cryogenic temperatures. People, especially children, have survived up to an hour without heartbeat after having fallen into ice water. Full recovery has been reached for up to 45 minutes. [] Cryonics "standby teams" wait by the bedside of cryonics patients to apply cooling and cardio-pulmonary support as soon as possible after declaration of death. Cryonicists do not believe that legal death is real death (irreversible destruction of the anatomical basis of mind) any more than conventional medicine now accepts that cessation of heartbeat is "real death", when the heart can be restarted with a defibrillator.

Scientific controversy regarding cryonics

Although cryonics is not current science, many scientists support the idea based on their expectations of the capabilities of future science. [cite web | url = http://www.cryoletter.org/
title = Scientists' Open Letter on Cryonics] No mammal has been cryopreserved and brought back to life. Nonetheless, vitrification has made remarkable strides in eliminating freezing damage and maintaining viability of cryopreserved tissues, including functional kidneys. Life extensionists compare cryopreservation skeptics with the cloning skeptics of the recent past. Journalists routinely interview scientists who dismiss the possibilities of the field but whose grasp of the subject is questioned by life extensionists. The phrase most often quoted is that "believing cryonics could reanimate somebody who has been frozen is like believing you can turn a hamburger back into a cow." [cite web | url = http://www.alcor.org/notablequotes.html|title = Notable quotes on Cryonics] Some cryonics enthusiasts believe that this transformation will be "no problem" for nanotechnology.

Ethics and politics of cryonics

As a life extension practice, cryonics has been under attack for many of the same reasons as the other life extension practices. Additionally, however, some people appear to be aesthetically revolted by the practice of cryopreserving "dead bodies" and especially of cryopreserving the head ("neuropreservation"). (The term "neuropreservation" implies just the brain, but in fact the entire head is cryopreserved, so the word is a slight misnomer.)

Almost from the beginning the Society for Cryobiology has attacked cryonics as being "fraud" and "quackery" and has banned cryonicists from being members of the Society. There are cryonicists who are members, but they are necessarily discreet about their affiliations. Most of the members of the Society have also made it clear that they have non-scientific grounds for their hostility, including the usual anti-life extension arguments as well as aesthetic arguments.

As a result of a media circus surrounding following a 2003 Sports Illustrated article claiming that Alcor had mishandled the body of baseball super-star Ted Williams, [cite journal | title=What happened to Ted?|journal= Sports Illustrated | year=2003| url = http://sportsillustrated.cnn.com/baseball/news/2003/08/12/williams_si/index.html] [cite journal | title=Ted's trajedy unfolds | journal= Sports Illustrated | year=2003| url = http://sportsillustrated.cnn.com/inside_game/tom_verducci/news/2003/08/12/insider/index.html] [cite journal | title=Renewed Ted Williams Controversy: An Interim Response | journal=Alcor News Bulletin Number |issue=15 | year=2003| url = http://www.alcor.org/printable.cgi?fname=Library%2Fhtml%2Falcornews015.html] a bill was passed in 2004 by the Arizona House of Representatives to place cryonics and cryonics procedures under the regulation of the state funeral board. In its original form, the law would have prevented Alcor's use of the Uniform Anatomical Gift Act. The bill was withdrawn while under consideration in the Arizona Senate. [cite web
url = http://www.alcor.org/printable.cgi?fname=Library%2Fhtml%2Flegislation.html
title = Chronology of Attempted 2004 Cryonics Legislation in Arizona
publisher = Alcor Life Extension Foundation
year = 2004] Although the Cryonics Institute (CI) was not responsible for Ted Williams, the media attention resulted in CI being placed under a "Cease and Desist" order by the State of Michigan for six months. Finally the Michigan government decided to regulate CI as a cemetery.

There are many people who have negative feelings about cryonics in general, and Alcor in particular. The Ted Williams affair has become a focus of such people. In many cases, cryonics was less an issue than the perception that the final wishes of Williams had not been respected and that Williams had not been treated with dignity.

SENS (Strategies for Engineered Negligible Senescence)

Dr. Aubrey de Grey has suggested that it will someday be possible for humans to live thousands of years in a youthful condition. He calls his project to reverse the damage we call "aging" SENS (Strategies for Engineered Negligible Senescence) (de Grey's book "Ending Aging" which outlines SENS in detail was published in September 2007). SENS is a novel program which aims to research and develop engineering-like strategies for the indefinite extension of life in individuals, rather like one might attempt to indefinitely keep a classic car in working order by various types of intervention, including improving the robustness of existing components by replacement or modification. De Grey has proposed seven strategies to address the "seven deadly things":

# Cell loss can be repaired (reversed) just by suitable exercise, in the case of muscle. For other tissues, it needs various growth factors to stimulate cell division; in some cases it needs stem cells.
# Senescent cells can be removed by activating the immune system against them. Or they can be destroyed by gene therapy to introduce "suicide genes" that only kill senescent cells.
# Protein cross-linking can largely be reversed by drugs that break the links. But to break some of the cross-links we may need to develop enzymatic methods.
# Extracellular garbage (like amyloid) can be eliminated by vaccination that gets immune cells to "eat" the garbage.
# For intracellular junk we need to introduce new enzymes, possibly enzymes from soil bacteria, that can degrade the junk (lipofuscin) that our own natural enzymes cannot degrade.
# For mitochondrial mutations the plan is not to repair them but to prevent harm from the mutations by putting suitably modified copies of the mitochondrial genes into the cell nucleus by gene therapy. The mitochondrial DNA experiences a high degree of mutagenic damage because most free radicals are generated in the mitochondria and because the DNA repair mechanisms of mitochondrial DNA are significantly inferior to those of nuclear DNA. A copy of the mitochondrial DNA located in the nucleus will be better protected from free radicals, and there will be better DNA repair when damage occurs. All mitochondrial proteins would then be imported into the mitochondria.
# For cancer (the most lethal consequence of mutations) the strategy is to use gene therapy to delete the genes for telomerase and to eliminate telomerase-independent mechanisms of turning normal cells into "immortal" cancer cells. To compensate for the loss of telomerase in stem cells we would introduce new stem cells every decade or so.

Dr. de Grey co-founded the Methuselah Mouse Prize, which awards money to researchers who can extend the lifespan of mice or rejuvenate mice.

Scientific controversy regarding SENS

In February 2005, "Technology Review", which is owned by the Massachusetts Institute of Technology, published an article by Sherwin Nuland, a Clinical Professor of Surgery at Yale University and the author of "How We Die" (ISBN 0-679-74244-1), that drew a skeptical portrait of Aubrey de Grey. [cite journal | author= Sherwin Nuland | title= Do You Want to Live Forever?|journal= Technology Review | year= 2005| issue= February | url = http://www.technologyreview.com/articles/05/02/issue/feature_aging.asp] While admiring de Grey's intelligence, Nuland concluded that he "would surely destroy us in attempting to preserve us" because living for such long periods would undermine what it means to be human. The article made no attempt to address the science of SENS, and this omission was severely criticized by many readers. In response, Jason Pontin (the magazine's editor) has offered $10,000 to any gerontologist who can convince an independent review panel that de Grey's ideas about radical life-extension have no merit. De Grey's Methuselah Foundation matched the $10,000, making the prize for debunking him $20,000.

In March, of 2006, "Technology Review" announced that it had chosen a panel of judges for the Challenge. On July 11, 2006, "Technology Review" published the results of the SENS Challenge. In the end, no one won the $20,000 prize. The judges felt that no submission met the criterion of the challenge and disproved SENS, although they unanimously agreed that one submission, by Preston Estep and his colleagues, was the most eloquent. In publishing the results, "Technology Review" also announced that it would make a $10,000 payment to Estep et al. in recognition of what the publication called their "careful scholarship." Although Estep et al. voiced their disapproval in a subsequent article, reiterating that they did agree with the goal of human life extension but considered that de Grey's approach was clearly pseudoscientific and that the panel of judges were mistaken in not admitting this (a position which Dr. de Grey characterised as “protest at the Challenge judges' failure to see SENS their way”). Estep et al. donated the entirety of the $10,000 to the American Federation for Aging Research.

Suspended animation

Suspended animation is the slowing of life processes by external means without termination. Breathing, heartbeat, and other involuntary functions may still occur, but they can only be detected by artificial means. Extreme cold is used to precipitate the slowing of an individual's functions. Although the technique has not been applied to human, experiments are successful in dogs, pigs and mice. Scientists drain the blood from animals' bodies and put an ice-cold solution into their circulatory systems. After being clinically dead for three hours, their blood is put back into their circulatory systems, and the dogs are revived by delivering an electric shock to their hearts. Scientists also have done similar experiments on pigs and tested 200 times with a 90 percent success rate." [cite news|url=http://www.pittsburghlive.com/x/tribune-review/trib/regionals/s_348517.html|title=Pitt scientists resurrect hope of cheating death|publisher=Pittsburgh Tribune-Review|date=2005-06-29|accessdate=2006-10-10|author=Jennifer Bails] [cite news|url=http://www.smh.com.au/articles/2006/01/20/1137553739997.html|title=Doctors claim suspended animation success|publisher=The Sidney Morning Herald|date=2006-01-20|accessdate=2006-10-10] There are also experiments reports success towards inducing suspended animation in mice by using chemical method, [cite news|url=http://news.bbc.co.uk/2/hi/health/5412824.stm|title=Gas induces 'suspended animation'|publisher=BBC News|date=2006-10-09|accessdate=2006-10-10] according to an article published in the scientific journal "Science" on April 22, 2005.

Mind uploading

Mind uploading is the transfer of the human mind/consciousness to a more durable material vessel (stereotypically but not necessarily a silicon computer). The concept is based on materialism, the philosophy of mind that argues that the human spirit is entirely composed of a very complex system of physical and chemical interactions. However, it is not understood how consciousness exists, and thus no existing scientific understanding for "reading" the "contents" of a human mind. With computer power increasing exponentially, and technology in the pipeline to keep up the trend, futurist Ray Kurzweil predicts that computer hardware will be powerful enough to run a functional model of the human mind by the 2020s. Several developing technologies hypothetically allow the complete mapping of human brains on a similar timescale. Uploading the human mind to a computer, if possible, would potentially greatly extend human lifespan due to the ability to construct highly durable computer hardware and the potential to copy or transfer the mind to multiple computers.

Scientific controversy regarding mind uploading

There is no scientific understanding that explains the detailed functioning of the human consciousness. A "reading" of the "contents" of a human mind is thus a purely speculative hypothesis.

However, a key objection, if science were able to read and transfer the mind's contents, and a model of a human mind was then actually moved to a computer, would the personal identity of that human be retained? And what would be the status of personal identity after duplication?

A possible solution to the first objection is to interface biological humans brains with computer parts, and the gradual replacement of biological components with mechanical ones — functionally no different to the biological renewal of synapses. The philosophical Ship of Theseus enigma still remains with this solution.

The difficulty in seeing mind uploading as a solution is along the same lines of mind cloning and transporter duality paradox. The situation is contemplated where the mind is uploaded, yet the original mind remains. In this case, the person will still be themselves, and the clone will be alien to them, and vice versa. The biological mind would view itself as the original, but would die. The computer mind would view itself as original yet artificial. If the clone is a separate individual, then the consciousness of the original would still die. Even in the case where there is never a clone (killing the original upon mind uploading, or the gradual replacement of biological components) while the distinction would be less apparent, it would still be applicable in some regards.

History of life extension and the life extension movement

In 1970, the American Aging Association was formed under the impetus of Denham Harman originator of the free radical theory of aging. Harman wanted an organization of biogerontologists that was devoted to research and to the sharing of information among scientists interested in extending human lifespan.

Although the desire to extend life can be traced as far back as the Epic of Gilgamesh, it was the 1982 bestselling book "" (ISBN 0-446-51229-X) by Durk Pearson and Sandy Shaw that popularized the phrase. In that book the authors detailed six major causes of aging, and presented dietary supplementation strategies for slowing down five of those. They also emphasized improving the quality of life, presenting methods of using the same dietary supplements that extend life to enhance sex (sex drive and sexual performance), cognitive function (intelligence, concentration, memory, mental stamina, etc.), stress management, sleep (quality of sleep, sleep reduction, and fast recovery from jet lag), athletic performance, body building, sports medicine, etc. The authors' two-pronged approach (showing how to live long and live well) makes their book a virtual nutritional toolbox, and this may account for why the book was so successful at kickstarting the life extension movement. Many other authors have followed this general strategy, promoting the "quality of life" applications of nutrients and drugs to attract readers to the subject of life extension.

The 1980 book "The Life Extension Revolution" (ISBN 0-688-03580-9) by Saul Kent did not sell so well. But Mr. Kent appeared on the "Merv Griffin Show" with Pearson and Shaw, and was able to use the flood of letters to create the nutraceutical firm called the Life Extension Foundation, which is non-profit. The Life Extension Foundation has grown to produce a magazine which has a large circulation. The group has a track record which includes promoting the benefits of many health supplements such as S-adenosyl methionine and melatonin many years before the medical field accepted the benefits of those substances.

Money generated by the Life Extension Foundation allowed Saul Kent to finance the Alcor Life Extension Foundation, the largest cryonics organization. The cryonics movement had been launched in 1962 by Robert Ettinger's book, "The Prospect of Immortality". In the 1960s, Saul Kent had been a co-founder of the Cryonics Society of New York. Alcor gained national prominence when the baseball star Ted Williams was cryonically preserved by Alcor in 2002 and a family dispute arose as to whether Ted had really wanted to be cryopreserved.

In 1983, Dr. Roy Walford, a life-extensionist gerontologist published a popular book called "Maximum Lifespan". Later, Dr. Walford and his student Dr. Richard Weindruch summarized years of their research into the ability of calorie restriction to extend the lifespan of rodents in their 1988 scholarly work "The Retardation of Aging and Disease by Dietary Restriction" (ISBN 0-398-05496-7). It had been known since the work of Clive McCay in the 1930s that calorie restriction can extend the maximum lifespan of rodents. But it was the work of Walford and Weindruch that gave detailed scientific grounding to that knowledge. Walford's personal interest in life extension motivated his scientific work and he practiced calorie restriction himself. Dr. Walford died at the age of 80 from complications caused by amyotrophic lateral sclerosis, a disease not firmly related to aging with causes still not understood.

For years the Food and Drug Administration (FDA) was in contention with the Life Extension Foundation, including through seizure of merchandise and court action. The FDA did not regard aging as a disease or life extension as a valid treatment category. In 1991 Saul Kent and Bill Faloon, the principals of the Foundation were jailed and told by the FDA that they would become the target of criminal indictments that would "destroy their lives forever" [cite journal | author=Saul Kent | title= Victory over the FDA | journal=Life Extension | year=1996 | issue=September | url=http://www.lef.org/magazine/mag96/sept96_freedom4.html ] and were advised to plead guilty of crimes against the state. Against legal advice, Kent and Faloon fought the FDA in court and filed countercharges concerning their mistreatment. In 1995 the FDA informed Kent and Faloon that, in exchange for a guilty plea, they would not have to go to prison and could continue doing business on a more limited basis. Instead of pleading guilty, Kent and Faloon filed a new battery of legal motions, escalated their counterattack against the FDA and began extensive preparations for their trial. In November 1995, the FDA dropped all charges except the charge of "obstruction of justice" against Saul Kent. In February 1996, this charge was also dropped.

In 1992 the American Academy of Anti-Aging Medicine (A4M) was formed to create an anti-aging medical specialty distinct from geriatrics, and to hold conferences for physicians interested in this field.

An important development in the life extension movement was the creation of the Usenet group, sci.life-extension. Brian M. Delaney created sci.life-extension in 1993, and the forum made possible, among other things, the creation of the CR Society.

A recent development in life extension has been the work of biogerontologist Aubrey de Grey of Cambridge University. Dr. de Grey proposes that damage to macromolecules, cells, tissues and organs can be repaired by advanced biotechnology.

The concept of actuarial escape velocity, invented by futurist and author Ray Kurzweil, posits that developments in life extension technology will reach a point at which the technology keeps pace with or even outpaces the rate at which humans age. This represents a kind of gateway to immortality.

Ethics and politics of life extension in general

Life extension is also associated with the potential problem of overpopulation. Leon Kass (chairman of the US President's Council on Bioethics from 2001 to 2005) has exemplified the anti-life extension viewcite web
last = Smith
first = Simon
title = Killing Immortality
url=http://www.imminst.org/forum/index.php?act=ST&f=67&t=446
accessdate = 2007-01-31 . He states his hostility to life extension with the words:

:"simply to covet a prolonged life span for ourselves is both a sign and a cause of our failure to open ourselves to procreation and to any higher purpose. … [The] desire to prolong youthfulness is not only a childish desire to eat one’s life and keep it; it is also an expression of a childish and narcissistic wish incompatible with devotion to posterity."cite book
last = Kass
first = Leon
authorlink = Leon Kass
title = Toward a More Natural Science
publisher = Free Press
date=1988
isbn = 0029170710

Some life extensionists perceive a lack of respect for individual choice in these words. This view would characterize Kass and others as seeking to use government power to ensure that no one's life is extended regardless of their wishes:

:"the finitude of human life is a blessing for every individual, whether he knows it or not."

In retort to Leon Kass's stance, transhumanist philosopher Nick Bostrom published an article titled "The Fable of the Dragon-Tyrant", [cite journal | author=Nick Bostrom | title=The Fable of the Dragon-Tyrant | journal=Journal of Medical Ethics | year=2005 | volume=31 | issue=5 | pages=273–277 |url=http://www.nickbostrom.com/fable/dragon.html | pmid=15863685 | doi=10.1136/jme.2004.009035 ] in which death is metaphorically personified as a monstrous dragon who demands horrific human sacrifices upon a mountain. A debate rages in the kingdom in the valley below between those who believe the dragon is a fact of life because he has existed for longer than any one can remember despite innumerable attempts to kill him, and those who believe the dragon is merely flesh and blood and that the kingdom has advanced to the point where a concerted effort may be mounted against him. In the end, the dragon-tyrant is killed by a ballistic missile launched from the valley, but not before a billion people die unnecessarily due to the initial fatalism and consequent inaction.

ee also

* List of life extension-related topics

Notes

References

Books:* "Biological Aging Measurement. Clinical Applications." Ward Dean, M.D. The Center for Bio-Gerontology. 1988. Paperback, 426pp. ISBN 0-937777-00-5:* "The Biology of Life Span: A Quantitative Approach". Leonid A. Gavrilov & Natalia S. Gavrilova (1991), New York: Harwood Academic Publisher, ISBN 3-7186-4983-7:* "Brain Boosters. Foods And Drugs That Make You Smarter." (A quote from the book: "It's hard to distinguish between the health and anti-aging uses of the smart drugs and nutrients.") Beverly Potter & Sebastian Orfali. Ronin Publishing. 1993. Paperback, 257 pages. ISBN 0-914171-65-8:* "Brain Fitness. Anti-Aging Strategies To Fight Alzheimer's Disease, Supercharge Your Memory, Sharpen Your Intelligence, De-Stress Your Mind, Control Mood Swings, and Much More..." Robert Goldman, M.D, D.O., Ph.D., With Ronald Klatz, M.D., D.O., and Liza Berger. Doubleday. 1995. Paperpack, 346pp. ISBN 0385488696 :* "The Directory of Life Extension Supplements." Life Extension Foundation. Published annually.:* "Fantastic Voyage: The Science Behind Radical Life Extension" Raymond Kurzweil and Terry Grossman M.D., [http://www.fantastic-voyage.net/] Rodale. 2004. 452pp. ISBN 1-57954-954-3:*"50 Simple Ways To Live A Longer Life: Everyday Techniques From The Forefront Of Science." Suzanne Bohan and Glenn Thompson. Sourcebooks. 2005. Paperback, 287 pages. ISBN 1-4022-0375-6:* "Formula for Life. The Definitive Book on Correct Nutrition, Anti-Oxidants and Vitamins, Disease Prevention, and Longevity." Eberhard Kronhausen, Ed. D, and Phyllis Kronhausen Ed. D., with Harry B. Demopoulos, M.D. William Morrow and Company. 1989. Paperback, 622 pages. ISBN 0-688-09426-0:* "How To Live Longer And Feel Better." Linus Pauling. W.H. Freeman and Company. 1986. Paperback, 413 pages. ISBN 0-380-70289-4:* "Life Extension. A Practical Scientific Approach. Adding Years to Your Life and Life to Your Years. Durk Pearson and Sandy Shaw." Warner Books. 1982. Hardcover, 858pp. ISBN 0-446-51229-X:* "The Life Extension Companion. The Latest Breakthroughs in Health Science." Durk Pearson and Sandy Shaw. Warner Books. 1984. Hardcover, 430 pages. ISBN 0-446-51277-X:* "The Life Extension Revolution: The Definitive Guide to Better Health, Longer Life, and Physical Immortality." Saul Kent. 1980. Hard Cover. ISBN 0-688-03580-9:* "The Life Extension Revolution: The New Science of Growing Older Without Aging." Philip Lee, M.D. and Monica Reinagel Miller. Bantam. 2005. Hardcover, (416 pages). ISBN 0-553-80353-0:* "The Life Extension Weight Loss Programme." Durk Pearson and Sandy Shaw. :* "LifeSpan-Plus. 900 Natural Techniques To Live Longer. Rejuvenate Your Heart; Stay Infection-Free; Prevent a Stroke; Reduce Stress; Control Your Blood Pressure; Strengthen Your Bones; Eliminate Body Toxins." By the editors of Prevention Magazine. Rodale. 1990. Hardcover, 422 pages. ISBN 0-87857-908-7:* "Live Longer Now. The First One Hundred Years Of Your Life." Jon N. Leanard, Jack L. Hofer, and Nathan Pritikin. Grosset and Dunlap. 1974 (predates the life extension movement, and therefore lacks megadosing recommendations.) Paperpack, 232 pages. ISBN 0-441-48514-6:* "The Long Tomorrow." Michael Rose. [http://www.us.oup.com/us/catalog/general/subject/LifeSciences/EvolutionaryBiology/?view=usa&ci=0195179390] , Oxford University Press. 2005. ISBN 0195179390 :* "Merchants of Immortality. Chasing The Dream Of Human Life Extension." Stephen S. Hall. Houghton Mifflin Company. 2003. Paperback, 439 pp. ISBN 0-618-49221-6:* "Mind Food and Smart Pills. How To Increase Your Intelligence and Prevent Brain Aging." Ross Pelton. 1986. Paperback, 170pp. ISBN 0-936809-00-0:* "No More Dying. The Conquest Of Aging And The Extension Of Human Life." Joel Kurtzman and Phillip Gordon. Dell. 1976. Paperpback, 252 pages. ISBN 0-440-36247-4:* "Prevention's The Sugar Solution." Edited by Sari Harrar, Prevention Health News Editor. Rodale. 2005. Hardcover, 406 pages. ISBN 1-57954-912-8:* "Secrets of Life Extension. How to halt or reverse the aging process and live a long and healthy life. You can extend the rest of your life. All the new scientific breakthroughs" John A. Mann. Bantam Books. 1980. Paperback, 296 pages. ISBN 0-55323-450-1:* "Nutrition Against Disease." Dr. Roger J. Williams. Pitman Publishing Corporation. 1971 (predates megadosing). 370 pages. ISBN 0273318500:* "Smart Drugs & Nutrients. How To Improve Your Membory And Increase Your Intelligence Using The Latest Discoveries In Neuroscience." (Many of the substances in this book have life-extending or cell regenerating effects.) Ward Dean, M.D. and Joh Morgenthaler. B&J Publications. 1990. Paperback, 222pp. ISBN 0962741892 :* "Smart Drugs II: The Next Generation : New Drugs and Nutrients to Improve Your Memory and Increase Your Intelligence." Ward Dean (M.D.), John Morgenthaler, Steven Wm Fowkes. Smart Publications. 1993. Paperback, 287 pages. ISBN 0-9627418-7-6:* "Stop Aging Now! The Ultimate Plan For Staying Young & Reversing The Aging Process. Based On Cutting-Edge Research Revealing The Amazing Antiaging Powers Of Supplements, Herbs, & Food." Jean Carper. Harper Perennial. 1995. Paperback, 372pp. ISBN 0-06-098500-3:* "Stop the FDA. Save Your Health Freedom. Articles by Linus Pauling, PhD; Abram Hoffer, MD; Ward Dean, MD; Senator Orrin Hatch; Durk Pearson and Sandy Shaw; and many more." (Many essays on health politics, by various leaders of the Life Extension Movement). Edited by John Morgenthaler & Steven Wm. Fowkes. Health Freedom Publications. 1992. Paperback, 186pp. ISBN 0-9627418-8-4:* "The Wrinkle Cure. The All-Natural Formula for Stopping Time. Unlock the Power of Cosmeceuticals for Supple, Youthful Skin." Nicholas Perricone, M.D. Rodale. 2000. Hardcover, 208 pages. ISBN 1-57954-237-9:* "Your Personal Life-Extension Program. A Practical Guide to the New Science That Can Make You Stronger, Smarter, Sexier, More Energetic, and More Youthful." Saul Kent. Morrow. 1985. Hardcover, 384 pages. ISBN 0-688-00629-9

Scientific Journals:* [http://dovepress.com/articles.php?journal_id=63 "Clinical Interventions in Aging"] Editor-in-Chief: Dr Richard F Walker. Publisher: Dove Medical Press Ltd. ISSN 1176-9092. Published Quarterly:* [http://www.liebertpub.com/rej/ "Rejuvenation Research"] Editor: Aubrey de Grey. Publisher: Mary Ann Liebert, Inc. ISSN 1549-1684 - Published Quarterly

External links

* [http://www.worldhealth.net American Academy of Anti-Aging Medicine]
* [http://www.arclab.org Aging Research Centre]
* [http://news.bbc.co.uk/1/hi/uk/4003063.stm Aubrey de Grey: 'We will be able to live to 1,000']
* [http://www.kurzweilai.net/news/frame.html?main=/news/news.html?cat%3D14%26d%3D0 Kurzweil Biomed/Life Extension News]
* [http://www.lef.org/ Life Extension Foundation web site]
* [http://www.longevitymeme.org/articles/ Longevity Meme]
* [http://www.benbest.com/lifeext/aging.html Mechanisms of Aging]
* [http://ouroboros.wordpress.com/ Ouroboros Anti-Aging Research News] Written by scientists for scientists
* [http://www.vitaeinstitute.org Vitae Institute] non-profit for developing life-extension technology through basic research