Parathyroid hormone receptor 2

Parathyroid hormone receptor 2, also known as PTHR2, is a human gene.cite web | title = Entrez Gene: PTHR2 parathyroid hormone receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5746| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a member of the G-protein coupled receptor family 2. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas.cite web | title = Entrez Gene: PTHR2 parathyroid hormone receptor 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5746| accessdate = ]

ee also

* Parathyroid hormone receptor

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Usdin TB, Gruber C, Bonner TI |title=Identification and functional expression of a receptor selectively recognizing parathyroid hormone, the PTH2 receptor. |journal=J. Biol. Chem. |volume=270 |issue= 26 |pages= 15455–8 |year= 1995 |pmid= 7797535 |doi=
*cite journal | author=Usdin TB, Modi W, Bonner TI |title=Assignment of the human PTH2 receptor gene (PTHR2) to chromosome 2q33 by fluorescence in situ hybridization. |journal=Genomics |volume=37 |issue= 1 |pages= 140–1 |year= 1997 |pmid= 8921382 |doi= 10.1006/geno.1996.0532
*cite journal | author=Clark JA, Bonner TI, Kim AS, Usdin TB |title=Multiple regions of ligand discrimination revealed by analysis of chimeric parathyroid hormone 2 (PTH2) and PTH/PTH-related peptide (PTHrP) receptors. |journal=Mol. Endocrinol. |volume=12 |issue= 2 |pages= 193–206 |year= 1998 |pmid= 9482662 |doi=
*cite journal | author=Hoare SR, Clark JA, Usdin TB |title=Molecular determinants of tuberoinfundibular peptide of 39 residues (TIP39) selectivity for the parathyroid hormone-2 (PTH2) receptor. N-terminal truncation of TIP39 reverses PTH2 receptor/PTH1 receptor binding selectivity. |journal=J. Biol. Chem. |volume=275 |issue= 35 |pages= 27274–83 |year= 2000 |pmid= 10854439 |doi= 10.1074/jbc.M003910200
*cite journal | author=John MR, Arai M, Rubin DA, "et al." |title=Identification and characterization of the murine and human gene encoding the tuberoinfundibular peptide of 39 residues. |journal=Endocrinology |volume=143 |issue= 3 |pages= 1047–57 |year= 2002 |pmid= 11861531 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Seeliger S, Hausberg M, Eue I, "et al." |title=The parathyroid hormone-2 receptor is expressed on human leukocytes and down-regulated in hyperparathyroidism. |journal=Clin. Nephrol. |volume=59 |issue= 6 |pages= 429–35 |year= 2003 |pmid= 12834174 |doi=
*cite journal | author=Bisello A, Manen D, Pierroz DD, "et al." |title=Agonist-specific regulation of parathyroid hormone (PTH) receptor type 2 activity: structural and functional analysis of PTH- and tuberoinfundibular peptide (TIP) 39-stimulated desensitization and internalization. |journal=Mol. Endocrinol. |volume=18 |issue= 6 |pages= 1486–98 |year= 2004 |pmid= 14988434 |doi= 10.1210/me.2003-0487
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Mahon MJ, Shimada M |title=Calmodulin interacts with the cytoplasmic tails of the parathyroid hormone 1 receptor and a sub-set of class b G-protein coupled receptors. |journal=FEBS Lett. |volume=579 |issue= 3 |pages= 803–7 |year= 2005 |pmid= 15670850 |doi= 10.1016/j.febslet.2004.12.056

External links

* [http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1327 IUPHAR GPCR Database - Parathyroid Hormone Receptors]
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