Transferrin receptor

Transferrin receptor

protein
Name= transferrin receptor (p90, CD71)
caption=


width=
HGNCid=11763
Symbol=TFRC
AltSymbols=CD71, TFR1
EntrezGene=7037
OMIM=190010
RefSeq=NM_003234
UniProt=P02786
PDB=
ECnumber=
Chromosome=3
Arm=q
Band=29
LocusSupplementaryData=protein
Name= transferrin receptor 2
caption=


width=
HGNCid=11762
Symbol=TFR2
AltSymbols=HFE3, TFRC2
EntrezGene=7036
OMIM=604720
RefSeq=NM_003227
UniProt=Q9UP52
PDB=
ECnumber=
Chromosome=7
Arm=q
Band=22
LocusSupplementaryData=

Transferrin receptor (TfR) is a carrier protein for transferrin. It's needed for the import of iron into the cell and it's regulated in response to intracellular iron concentration. Thus, it maintains cellular iron homeostasis.

TfR production in the cell is regulated according to iron levels by iron response/regulatory element binding protein (IRE-BP). This protein binds to the hairpin like structure (IRE) that is in the 3' UTR of the TfR receptor. Once binding occurs, degradation of mRNA of IRE is inhibited.

ee also

* TFR2
* TFRC

External links

*
* http://sickle.bwh.harvard.edu/iron_transport.html
* http://www.miltenyibiotec.com/en/PG_595_386_CD71.aspx
*http://www.jbc.org/cgi/content/abstract/266/21/13925
* http://www.ncbi.nlm.nih.gov/pubmed/16904380
* http://www.ncbi.nlm.nih.gov/pubmed/16920030
* http://www.sciencedirect.com/science?_ob=MiamiCaptionURL&_method=retrieve&_udi=B6WCJ-4KM46WH-2&_


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