- Tumor necrosis factor receptor
-
TNFR/NGFR cysteine-rich region 
Structure of the soluble human 55 kd TNF receptor-human TNF beta complex[1]. Identifiers Symbol TNFR_c6 Pfam PF00020 InterPro IPR011614 PROSITE PDOC00561 SCOP 1tnr Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary A tumor necrosis factor receptor (TNFR), or death receptor, is a trimeric cytokine receptor that binds tumor necrosis factors (TNF). The receptor cooperates with an adaptor protein (such as TRADD, TRAF, RIP), which is important in determining the outcome of the response (e.g. apoptosis, inflammation).
Because "TNF" is often used to describe TNF alpha, "TNFR" is often used to describe the receptors that bind to TNF alpha - namely, CD120. However, there are several other members of this family that bind to the other TNFs.[2][3]
Contents
Members
Family members include:[2]
Type Protein Aliases Gene 1 (CD120) CD120a TNFRSF1A CD120b TNFRSF1B 3 Lymphotoxin β receptor TNFRSF3 LTBR 4 CD134 TNFRSF4 5 CD40 TNFRSF5 CD40 6 FAS TNFRSF6 FAS TNFRSF6B TNFRSF6B 7 CD27 TNFRSF7 CD27 8 CD30 TNFRSF8 9 CD137 TNFRSF9 10 TNFRSF10A DR4 TNFRSF10A TNFRSF10B DR5 TNFRSF10B TNFRSF10C TNFRSF10C TNFRSF10D TNFRSF10D 11 RANK TNFRSF11A Osteoprotegerin TNFRSF11B 12 TNFRSF12A Fn14 TNFRSF12A 13 TNFRSF13B TNFRSF13B TNFRSF13C TNFRSF13C 14 TNFRSF14 TNFRSF14 16 Nerve growth factor receptor TNFRSF16 NGFR 17 TNFRSF17 TNFRSF17 18 TNFRSF18 TNFRSF18 19 TNFRSF19 TNFRSF19 21 TNFRSF21 DR6 TNFRSF21 25 TNFRSF25 TNFRSF25 27 Ectodysplasin A2 receptor TNFRSF27 EDA2R References
- ^ Banner DW, D'Arcy A, Janes W, et al. (May 1993). "Crystal structure of the soluble human 55 kd TNF receptor-human TNF beta complex: implications for TNF receptor activation". Cell 73 (3): 431–45. doi:10.1016/0092-8674(93)90132-A. PMID 8387891.
- ^ a b Locksley RM, Killeen N, Lenardo MJ (2001). "The TNF and TNF receptor superfamilies: integrating mammalian biology". Cell 104 (4): 487–501. doi:10.1016/S0092-8674(01)00237-9. PMID 11239407.
- ^ Hehlgans T, Pfeffer K (2005). "The intriguing biology of the tumour necrosis factor/tumour necrosis factor receptor superfamily: players, rules and the games". Immunology 115 (1): 1–20. doi:10.1111/j.1365-2567.2005.02143.x. PMC 1782125. PMID 15819693. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1782125.
Further reading
- Kavurma MM, Tan NY, Bennett MR. (2008). "Death receptors and their ligands in atherosclerosis". Arterioscler Thromb Vasc Biol. 28 (10): 1694–702. doi:10.1161/ATVBAHA.107.155143. PMID 18669890.
- Hatano, E. (2007). "Tumor necrosis factor signaling in hepatocyte apoptosis.". J Gastroenterol Hepatol. 22: S43–44. doi:10.1111/j.1440-1746.2006.04645.x. PMID 17567463.
External links
Membrane proteins, receptors: cell surface receptors G protein-coupled receptor Class AClass BClass CClass DPheromone receptorClass EcAMP receptorClass FLigand-gated ion channel Enzyme-linked receptor Other/ungrouped Asialoglycoprotein receptor · Tumor necrosis factor receptor · Immunoglobulin superfamily · N-Acetylglucosamine receptor · Neuropilins · Transferrin receptor · EDAR · Lipoprotein receptor-related proteinCytokine receptors Chemokine receptor
(GPCRs)OtherTNF receptor 1-1011-2021-25JAK-STAT OtherIg superfamily IL-17 family S/T Apoptosis signaling pathway Fas path IntracellularDeath-inducing signaling complex
DAXX · ASK1
Cytochrome c · Caspase 9 · Caspase 3
pro-apoptotic: BAX · BAK1/Bcl-2 homologous antagonist killer · Bcl-2-associated death promoter
anti-apoptotic: Bcl-2 · Bcl-xLTNF path Tumor necrosis factor receptorIntracellularOther IntracellularCategories:- Cytokine receptors
- Apoptosis
- Biochemistry stubs
Wikimedia Foundation. 2010.
