Interleukin 1 receptor, type II

Interleukin 1 receptor, type II (IL1R2) also known as CD121b (Cluster of Differentiation 121b) is an interleukin receptor. IL1R2 also denotes its human gene.

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summary_text = The protein encoded by this gene is a cytokine receptor that belongs to the interleukin-1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Two alternatively spliced transcript variants encoding the same protein have been reported.cite web | title = Entrez Gene: IL1R2 interleukin 1 receptor, type II| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7850| accessdate = ]

ee also

* Cluster of differentiation
* Interleukin 1 receptor, type I

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=McMahan CJ, Slack JL, Mosley B, "et al." |title=A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. |journal=EMBO J. |volume=10 |issue= 10 |pages= 2821–32 |year= 1991 |pmid= 1833184 |doi=
*cite journal | author=Dripps DJ, Verderber E, Ng RK, "et al." |title=Interleukin-1 receptor antagonist binds to the type II interleukin-1 receptor on B cells and neutrophils. |journal=J. Biol. Chem. |volume=266 |issue= 30 |pages= 20311–5 |year= 1991 |pmid= 1834644 |doi=
*cite journal | author=Fasano MB, Cousart S, Neal S, McCall CE |title=Increased expression of the interleukin 1 receptor on blood neutrophils of humans with the sepsis syndrome. |journal=J. Clin. Invest. |volume=88 |issue= 5 |pages= 1452–9 |year= 1991 |pmid= 1834697 |doi=
*cite journal | author=Sadouk MB, Pelletier JP, Tardif G, "et al." |title=Human synovial fibroblasts coexpress IL-1 receptor type I and type II mRNA. The increased level of the IL-1 receptor in osteoarthritic cells is related to an increased level of the type I receptor. |journal=Lab. Invest. |volume=73 |issue= 3 |pages= 347–55 |year= 1995 |pmid= 7564267 |doi=
*cite journal | author=Symons JA, Young PR, Duff GW |title=Soluble type II interleukin 1 (IL-1) receptor binds and blocks processing of IL-1 beta precursor and loses affinity for IL-1 receptor antagonist. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 5 |pages= 1714–8 |year= 1995 |pmid= 7878046 |doi=
*cite journal | author=Arend WP, Malyak M, Smith MF, "et al." |title=Binding of IL-1 alpha, IL-1 beta, and IL-1 receptor antagonist by soluble IL-1 receptors and levels of soluble IL-1 receptors in synovial fluids. |journal=J. Immunol. |volume=153 |issue= 10 |pages= 4766–74 |year= 1994 |pmid= 7963543 |doi=
*cite journal | author=Giri JG, Wells J, Dower SK, "et al." |title=Elevated levels of shed type II IL-1 receptor in sepsis. Potential role for type II receptor in regulation of IL-1 responses. |journal=J. Immunol. |volume=153 |issue= 12 |pages= 5802–9 |year= 1995 |pmid= 7989776 |doi=
*cite journal | author=Re F, Muzio M, De Rossi M, "et al." |title=The type II "receptor" as a decoy target for interleukin 1 in polymorphonuclear leukocytes: characterization of induction by dexamethasone and ligand binding properties of the released decoy receptor. |journal=J. Exp. Med. |volume=179 |issue= 2 |pages= 739–43 |year= 1994 |pmid= 8294881 |doi=
*cite journal | author=Colotta F, Re F, Muzio M, "et al." |title=Interleukin-1 type II receptor: a decoy target for IL-1 that is regulated by IL-4. |journal=Science |volume=261 |issue= 5120 |pages= 472–5 |year= 1993 |pmid= 8332913 |doi=
*cite journal | author=Sambo P, Fadlon EJ, Sironi M, "et al." |title=Reactive oxygen intermediates cause rapid release of the interleukin-1 decoy receptor from human myelomonocytic cells. |journal=Blood |volume=87 |issue= 5 |pages= 1682–6 |year= 1996 |pmid= 8634411 |doi=
*cite journal | author=Larregina A, Morelli A, Kolkowski E, Fainboim L |title=Flow cytometric analysis of cytokine receptors on human Langerhans' cells. Changes observed after short-term culture. |journal=Immunology |volume=87 |issue= 2 |pages= 317–25 |year= 1996 |pmid= 8698397 |doi=
*cite journal | author=Liu C, Hart RP, Liu XJ, "et al." |title=Cloning and characterization of an alternatively processed human type II interleukin-1 receptor mRNA. |journal=J. Biol. Chem. |volume=271 |issue= 34 |pages= 20965–72 |year= 1996 |pmid= 8702856 |doi=
*cite journal | author=Colotta F, Saccani S, Giri JG, "et al." |title=Regulated expression and release of the IL-1 decoy receptor in human mononuclear phagocytes. |journal=J. Immunol. |volume=156 |issue= 7 |pages= 2534–41 |year= 1996 |pmid= 8786316 |doi=
*cite journal | author=Sébire G, Delfraissy JF, Demotes-Mainard J, "et al." |title=Interleukin-13 and interleukin-4 act as interleukin-6 inducers in human microglial cells. |journal=Cytokine |volume=8 |issue= 8 |pages= 636–41 |year= 1997 |pmid= 8894439 |doi= 10.1006/cyto.1996.0085
*cite journal | author=Lovenberg TW, Crowe PD, Liu C, "et al." |title=Cloning of a cDNA encoding a novel interleukin-1 receptor related protein (IL 1R-rp2). |journal=J. Neuroimmunol. |volume=70 |issue= 2 |pages= 113–22 |year= 1996 |pmid= 8898719 |doi=
*cite journal | author=van der Poll T, de Waal Malefyt R, Coyle SM, Lowry SF |title=Antiinflammatory cytokine responses during clinical sepsis and experimental endotoxemia: sequential measurements of plasma soluble interleukin (IL)-1 receptor type II, IL-10, and IL-13. |journal=J. Infect. Dis. |volume=175 |issue= 1 |pages= 118–22 |year= 1997 |pmid= 8985204 |doi=
*cite journal | author=Rauschmayr T, Groves RW, Kupper TS |title=Keratinocyte expression of the type 2 interleukin 1 receptor mediates local and specific inhibition of interleukin 1-mediated inflammation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=94 |issue= 11 |pages= 5814–9 |year= 1997 |pmid= 9159157 |doi=
*cite journal | author=Gomez E, Morel G, Cavalier A, "et al." |title=Type I and type II interleukin-1 receptor expression in rat, mouse, and human testes. |journal=Biol. Reprod. |volume=56 |issue= 6 |pages= 1513–26 |year= 1997 |pmid= 9166705 |doi=
*cite journal | author=Cannon JG, Angel JB, Abad LW, "et al." |title=Interleukin-1 beta, interleukin-1 receptor antagonist, and soluble interleukin-1 receptor type II secretion in chronic fatigue syndrome. |journal=J. Clin. Immunol. |volume=17 |issue= 3 |pages= 253–61 |year= 1997 |pmid= 9168406 |doi=
*cite journal | author=Fink GW, Norman JG |title=Specific changes in the pancreatic expression of the interleukin 1 family of genes during experimental acute pancreatitis. |journal=Cytokine |volume=9 |issue= 12 |pages= 1023–7 |year= 1998 |pmid= 9417814 |doi=

External links

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