Interleukin-7 receptor

Interleukin 7 receptor (IL7R) also known as CD127 (Cluster of Differentiation 127) is a type I cytokine receptor. IL7R also denotes its human gene.

PBB_Summary
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summary_text = The protein encoded by this gene is a receptor for interleukine 7 (IL7). The function of this receptor requires the interleukin 2 receptor, gamma chain (IL2RG), which is a common gamma chain shared by the receptors of various cytokines, including interleukine 2, 4, 7, 9, and 15. This protein has been shown to play a critical role in the V(D)J recombination during lymphocyte development. This protein is also found to control the accessibility of the TCR gamma locus by STAT5 and histone acetylation. Knockout studies in mice suggested that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. The functional defects in this protein may be associated with the pathogenesis of the severe combined immunodeficiency (SCID). cite web | title = Entrez Gene: IL7R interleukin 7 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3575| accessdate = ] It has also recently been linked to the pathogenesis of multiple sclerosis. cite web | title = Interleukin 7 receptor alpha chain (IL7R) shows allelic and functional association with multiple sclerosis| url = http://www.ncbi.nlm.nih.gov/pubmed/17660817| accessdate = ]

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Akashi K, Kondo M, Weissman IL |title=Role of interleukin-7 in T-cell development from hematopoietic stem cells. |journal=Immunol. Rev. |volume=165 |issue= |pages= 13–28 |year= 1999 |pmid= 9850848 |doi=10.1111/j.1600-065X.1998.tb01226.x
*cite journal | author=Appasamy PM |title=Biological and clinical implications of interleukin-7 and lymphopoiesis. |journal=Cytokines Cell. Mol. Ther. |volume=5 |issue= 1 |pages= 25–39 |year= 1999 |pmid= 10390077 |doi=
*cite journal | author=Al-Rawi MA, Mansel RE, Jiang WG |title=Interleukin-7 (IL-7) and IL-7 receptor (IL-7R) signalling complex in human solid tumours. |journal=Histol. Histopathol. |volume=18 |issue= 3 |pages= 911–23 |year= 2004 |pmid= 12792903 |doi=
*cite journal | author=Banham AH |title=Cell-surface IL-7 receptor expression facilitates the purification of FOXP3(+) regulatory T cells. |journal=Trends Immunol. |volume=27 |issue= 12 |pages= 541–4 |year= 2007 |pmid= 17045841 |doi= 10.1016/j.it.2006.10.002
*cite journal | author=Nishii K, Kita K, Miwa H, "et al." |title=c-kit gene expression in CD7-positive acute lymphoblastic leukemia: close correlation with expression of myeloid-associated antigen CD13. |journal=Leukemia |volume=6 |issue= 7 |pages= 662–8 |year= 1992 |pmid= 1378163 |doi=
*cite journal | author=Lynch M, Baker E, Park LS, "et al." |title=The interleukin-7 receptor gene is at 5p13. |journal=Hum. Genet. |volume=89 |issue= 5 |pages= 566–8 |year= 1992 |pmid= 1634235 |doi=10.1007/BF00219186
*cite journal | author=Pleiman CM, Gimpel SD, Park LS, "et al." |title=Organization of the murine and human interleukin-7 receptor genes: two mRNAs generated by differential splicing and presence of a type I-interferon-inducible promoter. |journal=Mol. Cell. Biol. |volume=11 |issue= 6 |pages= 3052–9 |year= 1991 |pmid= 2038316 |doi=
*cite journal | author=Goodwin RG, Friend D, Ziegler SF, "et al." |title=Cloning of the human and murine interleukin-7 receptors: demonstration of a soluble form and homology to a new receptor superfamily. |journal=Cell |volume=60 |issue= 6 |pages= 941–51 |year= 1990 |pmid= 2317865 |doi=10.1016/0092-8674(90)90342-C
*cite journal | author=Seckinger P, Fougereau M |title=Activation of src family kinases in human pre-B cells by IL-7. |journal=J. Immunol. |volume=153 |issue= 1 |pages= 97–109 |year= 1994 |pmid= 7515933 |doi=
*cite journal | author=Noguchi M, Nakamura Y, Russell SM, "et al." |title=Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. |journal=Science |volume=262 |issue= 5141 |pages= 1877–80 |year= 1994 |pmid= 8266077 |doi=10.1126/science.8266077
*cite journal | author=van der Plas DC, Smiers F, Pouwels K, "et al." |title=Interleukin-7 signaling in human B cell precursor acute lymphoblastic leukemia cells and murine BAF3 cells involves activation of STAT1 and STAT5 mediated via the interleukin-7 receptor alpha chain. |journal=Leukemia |volume=10 |issue= 8 |pages= 1317–25 |year= 1996 |pmid= 8709637 |doi=
*cite journal | author=Maraskovsky E, O'Reilly LA, Teepe M, "et al." |title=Bcl-2 can rescue T lymphocyte development in interleukin-7 receptor-deficient mice but not in mutant rag-1-/- mice. |journal=Cell |volume=89 |issue= 7 |pages= 1011–9 |year= 1997 |pmid= 9215624 |doi=10.1016/S0092-8674(00)80289-5
*cite journal | author=Corcoran AE, Riddell A, Krooshoop D, Venkitaraman AR |title=Impaired immunoglobulin gene rearrangement in mice lacking the IL-7 receptor. |journal=Nature |volume=391 |issue= 6670 |pages= 904–7 |year= 1998 |pmid= 9495344 |doi= 10.1038/36122
*cite journal | author=Puel A, Ziegler SF, Buckley RH, Leonard WJ |title=Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. |journal=Nat. Genet. |volume=20 |issue= 4 |pages= 394–7 |year= 1998 |pmid= 9843216 |doi= 10.1038/3877
*cite journal | author=Ye SK, Maki K, Kitamura T, "et al." |title=Induction of germline transcription in the TCRgamma locus by Stat5: implications for accessibility control by the IL-7 receptor. |journal=Immunity |volume=11 |issue= 2 |pages= 213–23 |year= 1999 |pmid= 10485656 |doi=10.1016/S1074-7613(00)80096-5
*cite journal | author=Benbernou N, Muegge K, Durum SK |title=Interleukin (IL)-7 induces rapid activation of Pyk2, which is bound to Janus kinase 1 and IL-7Ralpha. |journal=J. Biol. Chem. |volume=275 |issue= 10 |pages= 7060–5 |year= 2000 |pmid= 10702271 |doi=10.1074/jbc.275.10.7060
*cite journal | author=Roifman CM, Zhang J, Chitayat D, Sharfe N |title=A partial deficiency of interleukin-7R alpha is sufficient to abrogate T-cell development and cause severe combined immunodeficiency. |journal=Blood |volume=96 |issue= 8 |pages= 2803–7 |year= 2000 |pmid= 11023514 |doi=
*cite journal | author=Reche PA, Soumelis V, Gorman DM, "et al." |title=Human thymic stromal lymphopoietin preferentially stimulates myeloid cells. |journal=J. Immunol. |volume=167 |issue= 1 |pages= 336–43 |year= 2001 |pmid= 11418668 |doi=

External links

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