Interleukin-23 receptor

Interleukin 23 receptor is a type I cytokine receptor. IL23R is its human gene.cite web | title = Entrez Gene: IL23R interleukin 23 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=149233| accessdate = ]

PBB_Summary
section_title =
summary_text = The protein encoded by this gene is a subunit of the receptor for IL23A/IL23. This protein pairs with the receptor molecule IL12RB1/IL12Rbeta1, and both are required for IL23A signaling. This protein associates constitutively with Janus kinase 2 (JAK2), and also binds to transcription activator STAT3 in a ligand-dependent manner.cite web | title = Entrez Gene: IL23R interleukin 23 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=149233| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Parham C, Chirica M, Timans J, "et al." |title=A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. |journal=J. Immunol. |volume=168 |issue= 11 |pages= 5699–708 |year= 2002 |pmid= 12023369 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Zhang XY, Zhang HJ, Zhang Y, "et al." |title=Identification and expression analysis of alternatively spliced isoforms of human interleukin-23 receptor gene in normal lymphoid cells and selected tumor cells. |journal=Immunogenetics |volume=57 |issue= 12 |pages= 934–43 |year= 2006 |pmid= 16372191 |doi= 10.1007/s00251-005-0067-0
*cite journal | author=Gregory SG, Barlow KF, McLay KE, "et al." |title=The DNA sequence and biological annotation of human chromosome 1. |journal=Nature |volume=441 |issue= 7091 |pages= 315–21 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727
*cite journal | author=Duerr RH, Taylor KD, Brant SR, "et al." |title=A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. |journal=Science |volume=314 |issue= 5804 |pages= 1461–3 |year= 2006 |pmid= 17068223 |doi= 10.1126/science.1135245
*cite journal | author=Cargill M, Schrodi SJ, Chang M, "et al." |title=A large-scale genetic association study confirms IL12B and leads to the identification of IL23R as psoriasis-risk genes. |journal=Am. J. Hum. Genet. |volume=80 |issue= 2 |pages= 273–90 |year= 2007 |pmid= 17236132 |doi= 10.1086/511051
*cite journal | author=Dubinsky MC, Wang D, Picornell Y, "et al." |title=IL-23 receptor (IL-23R) gene protects against pediatric Crohn's disease. |journal=Inflamm. Bowel Dis. |volume=13 |issue= 5 |pages= 511–5 |year= 2007 |pmid= 17309073 |doi= 10.1002/ibd.20126
*cite journal | author=Tremelling M, Cummings F, Fisher SA, "et al." |title=IL23R variation determines susceptibility but not disease phenotype in inflammatory bowel disease. |journal=Gastroenterology |volume=132 |issue= 5 |pages= 1657–64 |year= 2007 |pmid= 17484863 |doi= 10.1053/j.gastro.2007.02.051
*cite journal | author=Cummings JR, Ahmad T, Geremia A, "et al." |title=Contribution of the novel inflammatory bowel disease gene IL23R to disease susceptibility and phenotype. |journal=Inflamm. Bowel Dis. |volume=13 |issue= 9 |pages= 1063–8 |year= 2007 |pmid= 17508420 |doi= 10.1002/ibd.20180
*cite journal | author=Yamazaki K, Onouchi Y, Takazoe M, "et al." |title=Association analysis of genetic variants in IL23R, ATG16L1 and 5p13.1 loci with Crohn's disease in Japanese patients. |journal=J. Hum. Genet. |volume=52 |issue= 7 |pages= 575–83 |year= 2007 |pmid= 17534574 |doi= 10.1007/s10038-007-0156-z
*cite journal | author=Baldassano RN, Bradfield JP, Monos DS, "et al." |title=Association of variants of the interleukin-23 receptor gene with susceptibility to pediatric Crohn's disease. |journal=Clin. Gastroenterol. Hepatol. |volume=5 |issue= 8 |pages= 972–6 |year= 2007 |pmid= 17618837 |doi= 10.1016/j.cgh.2007.04.024
*cite journal | author=Sánchez E, Rueda B, Callejas JL, "et al." |title=Analysis of interleukin-23 receptor (IL23R) gene polymorphisms in systemic lupus erythematosus. |journal=Tissue Antigens |volume=70 |issue= 3 |pages= 233–7 |year= 2007 |pmid= 17661912 |doi= 10.1111/j.1399-0039.2007.00881.x
*cite journal | author=Orozco G, Rueda B, Robledo G, "et al." |title=Investigation of the IL23R gene in a Spanish rheumatoid arthritis cohort. |journal=Hum. Immunol. |volume=68 |issue= 8 |pages= 681–4 |year= 2007 |pmid= 17678723 |doi= 10.1016/j.humimm.2007.05.008
*cite journal | author=Oliver J, Rueda B, López-Nevot MA, "et al." |title=Replication of an association between IL23R gene polymorphism with inflammatory bowel disease. |journal=Clin. Gastroenterol. Hepatol. |volume=5 |issue= 8 |pages= 977–81, 981.e1–2 |year= 2007 |pmid= 17678845 |doi= 10.1016/j.cgh.2007.05.002
*cite journal | author=Raelson JV, Little RD, Ruether A, "et al." |title=Genome-wide association study for Crohn's disease in the Quebec Founder Population identifies multiple validated disease loci. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 37 |pages= 14747–52 |year= 2007 |pmid= 17804789 |doi= 10.1073/pnas.0706645104
*cite journal | author=Borgiani P, Perricone C, Ciccacci C, "et al." |title=Interleukin-23R Arg381Gln is associated with susceptibility to Crohn's disease but not with phenotype in an Italian population. |journal=Gastroenterology |volume=133 |issue= 3 |pages= 1049–51; author reply 1051–2 |year= 2007 |pmid= 17854611 |doi= 10.1053/j.gastro.2007.07.013

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