Interleukin-6 receptor

Interleukin 6 receptor (IL6R) also known as CD126 (Cluster of Differentiation 126) is a type I cytokine receptor.

Interleukin 6 (IL6) is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in immune response. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer.

tructure

The IL6 receptor is a protein complex consisting of a IL-6 receptor subunit (IL6R) and interleukin 6 signal transducer Glycoprotein 130. IL6R also denotes the human gene encoding this subunit. Alternatively spliced transcript variants encoding distinct isoforms have been reported. [cite web | title = Entrez Gene: IL6R interleukin 6 receptor| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3570| accessdate = ] IL6R subunit also shared by many other cytokines.

ee also

* Cluster of differentiation

References

Further reading

PBB_Further_reading
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*cite journal | author=Krause E, Wegenka U, Möller C, "et al." |title=Gene expression of the high molecular weight proteinase inhibitor alpha 2-macroglobulin. |journal=Biol. Chem. Hoppe-Seyler |volume=373 |issue= 7 |pages= 509–15 |year= 1992 |pmid= 1381187 |doi=
*cite journal | author=Schooltink H, Stoyan T, Roeb E, "et al." |title=Ciliary neurotrophic factor induces acute-phase protein expression in hepatocytes. |journal=FEBS Lett. |volume=314 |issue= 3 |pages= 280–4 |year= 1993 |pmid= 1281789 |doi=10.1016/0014-5793(92)81489-9
*cite journal | author=Schooltink H, Stoyan T, Lenz D, "et al." |title=Structural and functional studies on the human hepatic interleukin-6 receptor. Molecular cloning and overexpression in HepG2 cells. |journal=Biochem. J. |volume=277 ( Pt 3) |issue= |pages= 659–64 |year= 1991 |pmid= 1872801 |doi=
*cite journal | author=Szpirer J, Szpirer C, Rivière M, "et al." |title=The Interleukin-6-dependent DNA-binding protein gene (transcription factor 5: TCF5) maps to human chromosome 20 and rat chromosome 3, the IL6 receptor locus (IL6R) to human chromosome 1 and rat chromosome 2, and the rat IL6 gene to rat chromosome 4. |journal=Genomics |volume=10 |issue= 3 |pages= 539–46 |year= 1991 |pmid= 1889804 |doi=10.1016/0888-7543(91)90433-F
*cite journal | author=Sugita T, Totsuka T, Saito M, "et al." |title=Functional murine interleukin 6 receptor with the intracisternal A particle gene product at its cytoplasmic domain. Its possible role in plasmacytomagenesis. |journal=J. Exp. Med. |volume=171 |issue= 6 |pages= 2001–9 |year= 1990 |pmid= 2112585 |doi=10.1084/jem.171.6.2001
*cite journal | author=Snyers L, De Wit L, Content J |title=Glucocorticoid up-regulation of high-affinity interleukin 6 receptors on human epithelial cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=87 |issue= 7 |pages= 2838–42 |year= 1990 |pmid= 2157217 |doi=10.1073/pnas.87.7.2838
*cite journal | author=Hibi M, Murakami M, Saito M, "et al." |title=Molecular cloning and expression of an IL-6 signal transducer, gp130. |journal=Cell |volume=63 |issue= 6 |pages= 1149–57 |year= 1991 |pmid= 2261637 |doi=10.1016/0092-8674(90)90411-7
*cite journal | author=Novick D, Engelmann H, Wallach D, Rubinstein M |title=Soluble cytokine receptors are present in normal human urine. |journal=J. Exp. Med. |volume=170 |issue= 4 |pages= 1409–14 |year= 1989 |pmid= 2529343 |doi=10.1084/jem.170.4.1409
*cite journal | author=Taga T, Hibi M, Hirata Y, "et al." |title=Interleukin-6 triggers the association of its receptor with a possible signal transducer, gp130. |journal=Cell |volume=58 |issue= 3 |pages= 573–81 |year= 1989 |pmid= 2788034 |doi=10.1016/0092-8674(89)90438-8
*cite journal | author=Yamasaki K, Taga T, Hirata Y, "et al." |title=Cloning and expression of the human interleukin-6 (BSF-2/IFN beta 2) receptor. |journal=Science |volume=241 |issue= 4867 |pages= 825–8 |year= 1988 |pmid= 3136546 |doi=10.1126/science.3136546
*cite journal | author=Horiuchi S, Koyanagi Y, Zhou Y, "et al." |title=Soluble interleukin-6 receptors released from T cell or granulocyte/macrophage cell lines and human peripheral blood mononuclear cells are generated through an alternative splicing mechanism. |journal=Eur. J. Immunol. |volume=24 |issue= 8 |pages= 1945–8 |year= 1994 |pmid= 8056053 |doi=10.1002/eji.1830240837
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=10.1016/0378-1119(94)90802-8
*cite journal | author=Tamura T, Udagawa N, Takahashi N, "et al." |title=Soluble interleukin-6 receptor triggers osteoclast formation by interleukin 6. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=90 |issue= 24 |pages= 11924–8 |year= 1994 |pmid= 8265649 |doi=10.1073/pnas.90.24.11924
*cite journal | author=Kluck PM, Wiegant J, Jansen RP, "et al." |title=The human interleukin-6 receptor alpha chain gene is localized on chromosome 1 band q21. |journal=Hum. Genet. |volume=90 |issue= 5 |pages= 542–4 |year= 1993 |pmid= 8428753 |doi=10.1007/BF00217455
*cite journal | author=Chirmule N, Kalyanaraman VS, Lederman S, "et al." |title=HIV-gp 160-induced T cell-dependent B cell differentiation. Role of T cell-B cell activation molecule and IL-6. |journal=J. Immunol. |volume=150 |issue= 6 |pages= 2478–86 |year= 1993 |pmid= 8450224 |doi=
*cite journal | author=Yawata H, Yasukawa K, Natsuka S, "et al." |title=Structure-function analysis of human IL-6 receptor: dissociation of amino acid residues required for IL-6-binding and for IL-6 signal transduction through gp130. |journal=Embo J. |volume=12 |issue= 4 |pages= 1705–12 |year= 1993 |pmid= 8467812 |doi=
*cite journal | author=Pirozzi G, McConnell SJ, Uveges AJ, "et al." |title=Identification of novel human WW domain-containing proteins by cloning of ligand targets. |journal=J. Biol. Chem. |volume=272 |issue= 23 |pages= 14611–6 |year= 1997 |pmid= 9169421 |doi=10.1074/jbc.272.23.14611
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=10.1016/S0378-1119(97)00411-3
*cite journal | author=Matsuzaki K, Katayama K, Takahashi Y, "et al." |title=Human osteoclast-like cells are formed from peripheral blood mononuclear cells in a coculture with SaOS-2 cells transfected with the parathyroid hormone (PTH)/PTH-related protein receptor gene. |journal=Endocrinology |volume=140 |issue= 2 |pages= 925–32 |year= 1999 |pmid= 9927325 |doi=10.1210/en.140.2.925

External links

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