Interleukin-1 receptor

Interleukin-1 receptor

protein
Name = interleukin 1 receptor, type I
caption =


width =
HGNCid = 5993
Symbol = IL1R1
AltSymbols = IL1R, IL1RA
EntrezGene = 3554
OMIM = 147810
RefSeq = NM_000877
UniProt = P14778
PDB =
ECnumber =
Chromosome = 2
Arm = q
Band = 12
LocusSupplementaryData = protein
Name = interleukin 1 receptor, type II
caption =


width =
HGNCid = 5994
Symbol = IL1R2
AltSymbols = IL1RB
EntrezGene = 7850
OMIM = 147811
RefSeq = NM_173343
UniProt = P27930
PDB =
ECnumber =
Chromosome = 2
Arm = q
Band = 12
LocusSupplementaryData = protein
Name = interleukin 1 receptor accessory protein
caption =


width =
HGNCid = 5995
Symbol = IL1RAP
AltSymbols = IL-1RAcP, IL1R3, C3orf13
EntrezGene = 3556
OMIM = 602626
RefSeq = NM_134470
UniProt = Q9NPH3
PDB =
ECnumber =
Chromosome = 3
Arm = q
Band = 28
LocusSupplementaryData =

Interleukin-1 receptor (IL-1R) is a cytokine receptor which binds interleukin 1.cite journal | author = Kuno K, Matsushima K | title = The IL-1 receptor signaling pathway | journal = J. Leukoc. Biol. | volume = 56 | issue = 5 | pages = 542–7 | year = 1994 | pmid = 7964161 | doi = | issn = | url = http://www.jleukbio.org/cgi/content/abstract/56/5/542 | format = abstract page ] Two forms of the receptor exist. The type I receptor is primarily responsible for transmitting the inflammatory effects of interleukin-1 (IL-1) while type II receptors may act as a suppressor of IL-1 activity by competing for IL-1 binding. Also opposing the effects of IL-1 is the IL-1 receptor antagonist (IL-1RA).cite journal | author = Arend WP | title = Interleukin 1 receptor antagonist. A new member of the interleukin 1 family | journal = J. Clin. Invest. | volume = 88 | issue = 5 | pages = 1445–51 | year = 1991 | pmid = 1834696 | doi = | issn = | url = http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=1834696 ]

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