Interleukin 1 receptor antagonist

Interleukin 1 receptor antagonist

The IL-1 receptor antagonist (IL-1RA) was initially called the IL-1 inhibitor and was discovered separately in 1984 by two independent laboratories.C.A. Dinarello. The interleukin-1 family: 10 years of discovery. FASEB Journal. Volume 8, Issue 15, 1994, pages 1314-25. PMID 8001745] IL-1RA, is an agent which binds to the same receptor on the cell surface as IL-1 (IL1R), and thus prevents IL-1 from sending a signal to that cell. It is used in the treatment of rheumatoid arthritis, an autoimmune disease in which IL-1 plays a key role. It is commercially produced as anakinra, which is a human recombinant form of IL-1RA. In terms of protein similarities, IL-1β is more closely related to IL-1RA than it is to IL- 1α. The amino acids that are identical between mature human IL-1α and mature IL-1β is 22% while it is 26% when comparing IL-1β to IL-1RA and only 18% when comparing IL-1α to IL-1RA.

section_title =
summary_text = The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Four alternatively spliced transcript variants encoding distinct isoforms have been reported. [cite web | title = Entrez Gene: IL1RN interleukin 1 receptor antagonist| url =| accessdate = ]


Further reading

citations =
*cite journal | author=Arend WP, Malyak M, Guthridge CJ, Gabay C |title=Interleukin-1 receptor antagonist: role in biology. |journal=Annu. Rev. Immunol. |volume=16 |issue= |pages= 27–55 |year= 1998 |pmid= 9597123 |doi= 10.1146/annurev.immunol.16.1.27
*cite journal | author=Adcock IM, Ito K |title=Molecular mechanisms of corticosteroid actions. |journal=Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace / Fondazione clinica del lavoro, IRCCS [and] Istituto di clinica tisiologica e malattie apparato respiratorio, Università di Napoli, Secondo ateneo |volume=55 |issue= 3 |pages= 256–66 |year= 2000 |pmid= 10948677 |doi=
*cite journal | author=Arend WP |title=The balance between IL-1 and IL-1Ra in disease. |journal=Cytokine Growth Factor Rev. |volume=13 |issue= 4-5 |pages= 323–40 |year= 2003 |pmid= 12220547 |doi=
*cite journal | author=Sehouli J, Mustea A, Könsgen D, "et al." |title=Polymorphism of IL-1 receptor antagonist gene: role in cancer. |journal=Anticancer Res. |volume=22 |issue= 6A |pages= 3421–4 |year= 2003 |pmid= 12530098 |doi=
*cite journal | author=Kamangar F, Cheng C, Abnet CC, Rabkin CS |title=Interleukin-1B polymorphisms and gastric cancer risk--a meta-analysis. |journal=Cancer Epidemiol. Biomarkers Prev. |volume=15 |issue= 10 |pages= 1920–8 |year= 2007 |pmid= 17035400 |doi= 10.1158/1055-9965.EPI-06-0267

External links


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