Interleukin 12 receptor, beta 1 subunit

Interleukin 12 receptor, beta 1 is a subunit of the interleukin 12 receptor. IL12RB1, is its human gene.cite web | title = Entrez Gene: IL12RB1 interleukin 12 receptor, beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3594| accessdate = ] IL12RB1 is also known as CD212 (cluster of differentiation 212).

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summary_text = The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. The lack of expression of this gene was found to result in the immunodeficiency of patients with severe mycobacterial and Salmonella infections. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.cite web | title = Entrez Gene: IL12RB1 interleukin 12 receptor, beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3594| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=van de Vosse E, Lichtenauer-Kaligis EG, van Dissel JT, Ottenhoff TH |title=Genetic variations in the interleukin-12/interleukin-23 receptor (beta1) chain, and implications for IL-12 and IL-23 receptor structure and function. |journal=Immunogenetics |volume=54 |issue= 12 |pages= 817–29 |year= 2003 |pmid= 12671732 |doi= 10.1007/s00251-002-0534-9
*cite journal | author=Ling P, Gately MK, Gubler U, "et al." |title=Human IL-12 p40 homodimer binds to the IL-12 receptor but does not mediate biologic activity. |journal=J. Immunol. |volume=154 |issue= 1 |pages= 116–27 |year= 1995 |pmid= 7527811 |doi=
*cite journal | author=Gillessen S, Carvajal D, Ling P, "et al." |title=Mouse interleukin-12 (IL-12) p40 homodimer: a potent IL-12 antagonist. |journal=Eur. J. Immunol. |volume=25 |issue= 1 |pages= 200–6 |year= 1995 |pmid= 7843232 |doi=
*cite journal | author=Chua AO, Chizzonite R, Desai BB, "et al." |title=Expression cloning of a human IL-12 receptor component. A new member of the cytokine receptor superfamily with strong homology to gp130. |journal=J. Immunol. |volume=153 |issue= 1 |pages= 128–36 |year= 1994 |pmid= 7911493 |doi=
*cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171–4 |year= 1994 |pmid= 8125298 |doi=
*cite journal | author=Presky DH, Yang H, Minetti LJ, "et al." |title=A functional interleukin 12 receptor complex is composed of two beta-type cytokine receptor subunits. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 24 |pages= 14002–7 |year= 1997 |pmid= 8943050 |doi=
*cite journal | author=Gubler U, Presky DH |title=Molecular biology of interleukin-12 receptors. |journal=Ann. N. Y. Acad. Sci. |volume=795 |issue= |pages= 36–40 |year= 1997 |pmid= 8958915 |doi=
*cite journal | author=Zou J, Presky DH, Wu CY, Gubler U |title=Differential associations between the cytoplasmic regions of the interleukin-12 receptor subunits beta1 and beta2 and JAK kinases. |journal=J. Biol. Chem. |volume=272 |issue= 9 |pages= 6073–7 |year= 1997 |pmid= 9038232 |doi=
*cite journal | author=Yamamoto K, Kobayashi H, Miura O, "et al." |title=Assignment of IL12RB1 and IL12RB2, interleukin-12 receptor beta 1 and beta 2 chains, to human chromosome 19 band p13.1 and chromosome 1 band p31.2, respectively, by in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=77 |issue= 3-4 |pages= 257–8 |year= 1997 |pmid= 9284929 |doi=
*cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, "et al." |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149–56 |year= 1997 |pmid= 9373149 |doi=
*cite journal | author=Igarashi O, Yamane H, Imajoh-Ohmi S, Nariuchi H |title=IL-12 receptor (IL-12R) expression and accumulation of IL-12R beta 1 and IL-12R beta 2 mRNAs in CD4+ T cells by costimulation with B7-2 molecules. |journal=J. Immunol. |volume=160 |issue= 4 |pages= 1638–46 |year= 1998 |pmid= 9469420 |doi=
*cite journal | author=de Jong R, Altare F, Haagen IA, "et al." |title=Severe mycobacterial and Salmonella infections in interleukin-12 receptor-deficient patients. |journal=Science |volume=280 |issue= 5368 |pages= 1435–8 |year= 1998 |pmid= 9603733 |doi=
*cite journal | author=Kawashima T, Kawasaki H, Kitamura T, "et al." |title=Interleukin-12 induces tyrosine phosphorylation of an 85-kDa protein associated with the interleukin-12 receptor beta 1 subunit. |journal=Cell. Immunol. |volume=186 |issue= 1 |pages= 39–44 |year= 1998 |pmid= 9637763 |doi= 10.1006/cimm.1998.1294
*cite journal | author=Yao BB, Niu P, Surowy CS, Faltynek CR |title=Direct interaction of STAT4 with the IL-12 receptor. |journal=Arch. Biochem. Biophys. |volume=368 |issue= 1 |pages= 147–55 |year= 1999 |pmid= 10415122 |doi= 10.1006/abbi.1999.1302
*cite journal | author=Oppmann B, Lesley R, Blom B, "et al." |title=Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12. |journal=Immunity |volume=13 |issue= 5 |pages= 715–25 |year= 2001 |pmid= 11114383 |doi=
*cite journal | author=Altare F, Ensser A, Breiman A, "et al." |title=Interleukin-12 receptor beta1 deficiency in a patient with abdominal tuberculosis. |journal=J. Infect. Dis. |volume=184 |issue= 2 |pages= 231–6 |year= 2001 |pmid= 11424023 |doi=
*cite journal | author=Losana G, Rigamonti L, Borghi I, "et al." |title=Requirement for both IL-12 and IFN-gamma signaling pathways in optimal IFN-gamma production by human T cells. |journal=Eur. J. Immunol. |volume=32 |issue= 3 |pages= 693–700 |year= 2002 |pmid= 11857344 |doi=
*cite journal | author=Parham C, Chirica M, Timans J, "et al." |title=A receptor for the heterodimeric cytokine IL-23 is composed of IL-12Rbeta1 and a novel cytokine receptor subunit, IL-23R. |journal=J. Immunol. |volume=168 |issue= 11 |pages= 5699–708 |year= 2002 |pmid= 12023369 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Cleary AM, Tu W, Enright A, "et al." |title=Impaired accumulation and function of memory CD4 T cells in human IL-12 receptor beta 1 deficiency. |journal=J. Immunol. |volume=170 |issue= 1 |pages= 597–603 |year= 2003 |pmid= 12496448 |doi=

External links

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